【摘要】：目的對硫酸乙酰肝素(heparan sulfate,HS)在骨形成和骨重建方面的作用進行討論,綜述其成骨機制的最新研究進展。方法查閱國內外有關HS體外作用于成骨細胞系、HS和HS復合支架材料作用于骨缺損動物模型以及HS蛋白聚糖影響骨骼發(fā)育的研究文獻,并進行綜合分析。結果 HS長鏈通過非共價結合方式和參與骨折愈合的生長因子結合,尤其是肝素結合性生長因子(如FGFs、BMP、TGF-β)等,保護這些生長因子免受蛋白酶降解,并可直接參與生長因子信號轉導和骨細胞功能調節(jié)。HS調控成骨作用機制主要包括:刺激干細胞向成骨細胞分化、提高成骨細胞分化能力、促進骨基質形成、維持骨基質穩(wěn)定和加速骨基質礦化。結論 HS的成骨作用顯著,隨著對其安全性的不斷探索完善,HS可能成為臨床治療骨缺損延遲愈合和不愈合的有效手段,并有望為骨組織工程技術提供更多選擇。
[Abstract]:Objective to discuss the role of heparan sulfate heparin (heparan sulfate) in bone formation and bone reconstruction, and to review the latest research progress of its osteogenic mechanism. Methods the domestic and foreign literatures about the effects of HS on osteoblast cell line HS and HS composite scaffold on bone defect animal model and the effect of HS proteoglycan on bone development were reviewed and analyzed. Results HS long chain could protect these growth factors from protease degradation by non-covalent binding with growth factors involved in fracture healing, especially heparin binding growth factors (such as FGFsPMP TGF- 尾). The mechanism of regulating osteogenesis mainly includes stimulating the differentiation of stem cells into osteoblasts, enhancing the differentiation ability of osteoblasts, and promoting the formation of bone matrix, which can directly participate in the signal transduction of growth factor and the regulation of osteocyte function. Maintain bone matrix stability and accelerate bone matrix mineralization. Conclusion HS plays a significant role in osteogenesis, and with the continuous exploration and improvement of its safety, HS may become an effective method for the treatment of delayed healing and nonunion of bone defects, and it is expected to provide more options for bone tissue engineering techniques.
【作者單位】： 南京醫(yī)科大學附屬無錫市人民醫(yī)院骨科;江南大學藥學院藥用生物高分子研究室;
【基金】：國家自然科學基金面上項目(21574059)~~
【分類號】：R318.08;R68

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1 宋淑軍;王宗燁;;硫酸乙酰肝素在骨折愈合中的作用[J];生命的化學;2008年04期

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本文編號：2119903