本文選題：開放性骨折 + 感染�。� 參考：《中華醫(yī)院感染學(xué)雜志》2017年04期

【摘要】：目的探討開放性骨折感染患者血清促炎及抗炎因子表達,為開放性骨折感染的臨床診治提供參考。方法選取2014年8月-2015年8月在醫(yī)院診治100例開放性骨折患者為骨折組、同期門診進行健康體檢的50例正常人群為對照組,骨折組在入院后隔日、對照組在體檢時抽血檢測白細胞介素-6(IL-6)、腫瘤壞死因子-α(TNF-α)、白細胞介素-4(IL-4)、白細胞介素-10(IL-10)、可溶性腫瘤壞死因子受體I(sTNF-RI)水平,骨折組同時取創(chuàng)面分泌物行細菌培養(yǎng)。結(jié)果骨折組感染者21例,感染發(fā)生率為21.00%,培養(yǎng)出病原菌20株,分別為金黃色葡萄球菌12株、大腸埃希菌5株、表皮葡萄球菌2株、肺炎克雷伯菌1株,構(gòu)成比分別占60.00%、25.00%、10.00%、5.00%;骨折組患者IL-6、TNF-α、IL-4、IL-10、sTNF-RI水平均高于對照組(P0.05);骨折感染患者IL-6、TNF-α、IL-4、IL-10、sTNF-RI水平分別為(35.45±5.71)ng/L、(42.65±7.89)ng/L、(56.11±13.54)pg/ml、(71.83±15.40)μg/L、(3983.55±945.71)ng/L,均高于骨折無感染患者(14.45±3.56)ng/L、(22.43±4.67)ng/L、(30.32±5.21)pg/ml、(50.15±11.01)μg/L、(2168.61±480.32)ng/L,比較差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論開放性骨折患者血清促炎及抗炎因子表達均明顯升高,骨折感染可加重機體促炎及抗炎反應(yīng)。
[Abstract]:Objective to investigate the expression of serum proinflammatory and anti-inflammatory factors in patients with open fracture infection and to provide reference for the diagnosis and treatment of open fracture infection. Methods from August 2014 to August 2015, 100 patients with open fracture were treated in hospital as fracture group, and 50 healthy controls were selected as control group. The fracture group was treated every other day after admission. The levels of interleukin-6 (IL-6), tumor necrosis factor- 偽 (TNF- 偽), interleukin-4 (IL-4), interleukin-10 (IL-10) and soluble tumor necrosis factor receptor I (sTNF-RI) were measured in the control group. Results in fracture group, 21 cases were infected, the incidence of infection was 21.000.Twenty strains of pathogenic bacteria were cultured, including 12 strains of Staphylococcus aureus, 5 strains of Escherichia coli, 2 strains of Staphylococcus epidermidis and 1 strain of Klebsiella pneumoniae. 鏋勬垚姣斿垎鍒崰60.00%,25.00%,10.00%,5.00%;楠ㄦ姌緇勬?zhèn)ｈ�匢L-6,TNF-偽,IL-4,IL-10,sTNF-RI姘村鉤鍧囬珮浜庡鐓х粍(P0.05);楠ㄦ姌鎰熸煋鎮(zhèn)ｈ，

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