發(fā)布時(shí)間：2018-06-30 06:18

  本文選題：靜脈氧飽和度 + 動(dòng)脈氧飽和度　； 參考：《深圳大學(xué)》2015年碩士論文

【摘要】：靜脈氧飽和度(Sv O2:Venous Oxygen Saturation)是反映血液經(jīng)過毛細(xì)血管物質(zhì)交換后,含氧血紅蛋白(Hb O2:Oxyhemoglobin)占全部血紅蛋白(t Hb:total Hemoglobin)比例的指標(biāo)。相對于反映血液氧氣供給能力的動(dòng)脈氧飽和度(Sa O2:Arterial Oxygen Saturation),靜脈氧飽和度反映的是組織對氧氣的消耗能力與需求程度。靜脈氧飽和度的變化與動(dòng)脈氧飽和度、血紅蛋白(Hemoglobin)含量、心排量(CO:Cardiac Output),甚至是周圍環(huán)境都有一定關(guān)聯(lián),它不僅是反映人體呼吸功能的參數(shù)也是反映組織氧氣利用的一項(xiàng)指標(biāo),因此監(jiān)測靜脈氧飽和度對于準(zhǔn)確評估人體生理狀況具有相當(dāng)?shù)囊饬x。目前脈搏血氧儀(Pulse Oximetry)作為一種無創(chuàng)、連續(xù)動(dòng)脈氧飽和度監(jiān)測設(shè)備,已經(jīng)被廣泛應(yīng)用于臨床。但是市場上仍然沒有能夠無創(chuàng)、連續(xù)監(jiān)測靜脈氧飽和度的設(shè)備,有創(chuàng)測量設(shè)備由于其操作較為復(fù)雜、具有一定風(fēng)險(xiǎn)無法經(jīng)常使用,臨床上多數(shù)時(shí)候都是憑借醫(yī)生的經(jīng)驗(yàn)來判斷人體對氧氣的消耗和需求情況。然而通常情況下,不同人、不同器官的氧氣消耗量大相徑庭,即使是相同的人在不同的環(huán)境與狀態(tài)下對氧氣的需求量也不一樣。為了能夠無創(chuàng)、連續(xù)監(jiān)測靜脈氧飽和度的變化,本文在原有脈搏氧飽和度測量基本方法的基礎(chǔ)上,提出了一種新的基于光電容積波(Photoplethismograpyh)的無創(chuàng)、連續(xù)局部靜脈氧飽和度監(jiān)測方法。通過激勵(lì)系統(tǒng)人為地增強(qiáng)原本微弱的靜脈信號的強(qiáng)度,將脈搏氧測量過程中的靜脈干擾作為靜脈氧測量的有用信號,成功集到了靜脈光電容積波信號。并且利用搭建的硬件、軟件、算法平臺,對該方法進(jìn)行了缺氧狀態(tài)下的有創(chuàng)實(shí)驗(yàn)驗(yàn)證。實(shí)驗(yàn)結(jié)果表明,測試設(shè)備能夠有效反映缺氧狀態(tài)下靜脈氧飽和度的整體下降趨勢,人工添加激勵(lì)的方法既能有效增強(qiáng)了靜脈信號的強(qiáng)度,也不會影響動(dòng)脈信號的采集與處理。標(biāo)定后的測試設(shè)備與無創(chuàng)參考設(shè)備的脈搏氧飽和度測量結(jié)果,均方根誤差為0.845,相關(guān)系數(shù)為0.997;測試設(shè)備與有創(chuàng)參考設(shè)備的靜脈氧飽和度測量結(jié)果均方根誤差為7.75,相關(guān)系數(shù)為0.86;氧氣消耗量測量結(jié)果均方根誤差為2.47。此外,測試設(shè)備靜脈氧飽和度的測量結(jié)果部分趨勢,與手指末端循環(huán)的灌注指數(shù)(PI:Perfusion Index)存在一定關(guān)聯(lián),灌注指數(shù)增高時(shí)靜脈氧飽和度在一定范圍內(nèi)增高,灌注指數(shù)下降時(shí)靜脈氧飽和度也隨之下降。
[Abstract]:SvO2: Venous oxygen saturation (SvO2: Venous oxygen Saturation) is an index that reflects the proportion of HB O 2: oxygen hemoglobin to total hemoglobin after the capillary substance exchange. Compared with the arterial oxygen saturation (sa _ O _ 2: Arterial oxygen saturation), the venous oxygen saturation reflects the oxygen consumption and demand of the tissue. The changes of venous oxygen saturation are related to arterial oxygen saturation, hemoglobin content, CO: Cardiac output, and even the surrounding environment. It is not only a parameter reflecting human respiratory function, but also an index of tissue oxygen utilization. Therefore, monitoring venous oxygen saturation is of great significance for accurate evaluation of human physiological status. Pulse oximetry, as a noninvasive, continuous arterial oxygen saturation monitoring device, has been widely used in clinical practice. However, there is still no non-invasive, continuous monitoring equipment for venous oxygen saturation in the market. Because of its complex operation, the invasive measurement equipment is not used frequently because of its complex operation. Most of the clinical experience is based on the experience of the body to judge the consumption and demand for oxygen. Usually, however, oxygen consumption varies greatly from person to person and from organ to organ, and even the same person needs different oxygen in different environments and states. In order to continuously monitor the changes of venous oxygen saturation, a new non-invasive and continuous local venous oxygen saturation monitoring method based on photovoltaic volume wave (Photoplethismograpyh) is proposed based on the original method of pulse oxygen saturation measurement. By artificially increasing the intensity of the original weak venous signal, the venous interference in the pulse oxygen measurement process is taken as the useful signal for the venous oxygen measurement, and the venous photoelectric volume wave signal is successfully collected. Using the hardware, software and algorithm platform, the method is verified by the invasive experiment under anoxic condition. The experimental results show that the testing equipment can effectively reflect the overall decreasing trend of venous oxygen saturation under anoxic condition. The artificial stimulation method can not only effectively enhance the intensity of venous signals, but also will not affect the acquisition and processing of arterial signals. The measured results of pulse oxygen saturation of calibrated test equipment and noninvasive reference equipment, The root mean square error was 0.845, the correlation coefficient was 0.9977.The root mean square error was 7.75 and the correlation coefficient was 0.86, and the root mean square error of oxygen consumption was 2.47. In addition, some trends of venous oxygen saturation were related to the Pi: perfusion index of finger end circulation, and the venous oxygen saturation increased in a certain range when the perfusion index increased. The venous oxygen saturation decreased with the decrease of perfusion index.
【學(xué)位授予單位】：深圳大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R614

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