本文選題：骨關(guān)節(jié)炎 + 膝��； 參考：《中國(guó)全科醫(yī)學(xué)》2017年S1期

【摘要】：目的探討普瑞巴林聯(lián)合依托考昔治療膝關(guān)節(jié)骨關(guān)節(jié)炎疼痛的臨床療效。方法選取商丘市第一人民醫(yī)院2014年2月—2016年2月收治的膝骨關(guān)節(jié)炎疼痛患者80例,按照隨機(jī)數(shù)字表法將患者分為觀察組和對(duì)照組,各40例。觀察組患者予以普瑞巴林膠囊與依托考昔片治療,對(duì)照組患者予以依托考昔片治療,兩組患者均連續(xù)治療8周。比較兩組患者治療前、治療1周、4周及8周膝關(guān)節(jié)視覺(jué)模擬評(píng)分量表(VAS)評(píng)分、日�；顒�(dòng)程度量表(WOMAC)評(píng)分,治療前后焦慮自評(píng)量表(SAS)評(píng)分、匹茲堡睡眠質(zhì)量指數(shù)(PSQI)評(píng)分、肝腎功能指標(biāo)[谷丙轉(zhuǎn)氨酶(ALT),谷草轉(zhuǎn)氨酶(AST),血肌酐(Cr)、尿素氮(BUN)],觀察兩組患者不良反應(yīng)發(fā)生情況。結(jié)果治療前兩組患者膝關(guān)節(jié)VAS評(píng)分、WOMAC評(píng)分比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);治療1周、4周及8周觀察組患者膝關(guān)節(jié)VAS評(píng)分、WOMAC評(píng)分低于對(duì)照組(P0.05);兩組患者治療1周、4周及8周膝關(guān)節(jié)VAS評(píng)分、WOMAC評(píng)分低于治療前(P0.05)。治療前兩組患者SAS和PSQI評(píng)分比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);治療后觀察組患者SAS和PSQI評(píng)分低于對(duì)照組(P0.05);兩組患者治療后SAS評(píng)分低于治療前,觀察組患者治療后PSQI評(píng)分低于治療前(P0.05)。治療前后兩組患者ALT、AST、Cr和BUN水平比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。觀察組不良反應(yīng)發(fā)生率低于對(duì)照組(P0.05)。結(jié)論瑞普巴林聯(lián)合依托考昔治療膝關(guān)節(jié)骨關(guān)節(jié)炎疼痛的臨床療效確切,其鎮(zhèn)痛效果好,可有效改善患者膝關(guān)節(jié)功能、焦慮程度和睡眠質(zhì)量,安全性高。
[Abstract]:Objective to investigate the clinical effect of Premarin combined with oxicoxib in the treatment of knee osteoarthritis pain. Methods Eighty patients with knee osteoarthritis pain treated in the first people's Hospital of Shangqiu from February 2014 to February 2016 were randomly divided into observation group and control group with 40 cases each. The patients in the observation group were treated with Prebin capsule and etacoxib, while the patients in the control group were treated with the tablet for 8 weeks. The scores of visual analogue scale (VAS), daily activity scale (WOMAC), self rating anxiety scale (SAS) and Pittsburgh Sleep quality Index (PSQI) before and after treatment were compared between the two groups. The indexes of liver and kidney function [alt, AST, Cr, bun] were observed. Results VAS score and WOMAC score of knee joint were compared between the two groups before treatment. There was no significant difference between the two groups (P0.05); the VAS score of the knee joint in the observation group was lower than that in the control group at 1 week and 8 weeks (P0.05); the VAS score of the knee joint in the two groups was lower than that before the treatment (P0.05). There was no significant difference in SAS and PSQI scores between the two groups before treatment (P0.05); after treatment, the SAS and PSQI scores in the observation group were lower than those in the control group (P0.05); the SAS scores after treatment in the two groups were lower than those before treatment, and the PSQI scores in the observation group after treatment were lower than those before treatment (P0.05). Before and after treatment, there was no significant difference in alt ASTN Cr and bun levels between the two groups (P0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P0.05). Conclusion the clinical curative effect of the treatment of knee osteoarthritis pain with the combination of ripraxine and coxim is definite, and its analgesic effect is good. It can effectively improve the knee joint function, anxiety degree and sleep quality of the patients, and has high safety.
【作者單位】： 河南省商丘市第一人民醫(yī)院;
【分類(lèi)號(hào)】：R684.3

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本文編號(hào)：2072790