本文選題：血糖 + 化療��； 參考：《北京中醫(yī)藥大學(xué)》2015年碩士論文

【摘要】：本文包括文獻(xiàn)綜述和臨床研究兩部分。第一部分是文獻(xiàn)綜述,主要介紹了本課題研究的背景,即惡性腫瘤與糖尿病關(guān)系的研究進(jìn)展,主要包括以下幾部分：1.西醫(yī)對惡性腫瘤合并糖尿病的研究現(xiàn)狀,包含腫瘤和糖尿病的基本概念、流行病學(xué),糖尿病繼發(fā)惡性腫瘤的發(fā)病機制,糖尿病治療藥物繼發(fā)惡性腫瘤的可能機制,惡性腫瘤繼發(fā)糖尿病的可能機制,化療等腫瘤治療方式對血糖的影響；2.中醫(yī)對惡性腫瘤病因病機的認(rèn)識,中醫(yī)對糖尿病病因病機的認(rèn)識,中醫(yī)對惡性腫瘤合并糖尿病的認(rèn)識。第二部分為臨床研究,題目為化療對乳腺癌患者的血糖與中醫(yī)證候的影響。目的：主要進(jìn)行以下方面探討：(1)化療對乳腺癌患者空腹血糖的影響；(2)化療對乳腺癌患者中醫(yī)證型的影響；(3)影響化療后空腹血糖的相關(guān)因素。主要方法：采用回顧性統(tǒng)計分析的研究方法,分析2014年1月1日至2014年12月31日中日友好醫(yī)院中西醫(yī)結(jié)合腫瘤內(nèi)科收治的31例乳腺癌患者,統(tǒng)計化療前后的中醫(yī)證型、血糖、年齡、肝功能情況,分析化療對血糖和中醫(yī)證候的影響,以及化療方案、基礎(chǔ)血糖、年齡、肝功能情況與化療前后血糖變化的相關(guān)性。結(jié)果：1.化療后的血糖明顯高于化療前(P0.01),具有統(tǒng)計學(xué)意義14人出現(xiàn)一過性空腹血糖升高；2.基礎(chǔ)空腹血糖、年齡、肝功與化療后空腹血糖有統(tǒng)計學(xué)差異(P0.05)；3.不同化療方案相比對化療后空腹血糖影響無統(tǒng)計學(xué)差異(P0.05)。4.化療前單證以氣郁證、血瘀證為主,化療后以血瘀證、氣虛證為主,化療后氣虛證、血虛證、陰虛證較化療前增加。結(jié)論：1.化療后的血糖明顯高于化療前,化療可導(dǎo)致空腹血糖異常；2.基礎(chǔ)空腹血糖、年齡、肝功是化療后空腹血糖相關(guān)因素；3.化療方案對化療后空腹血糖無影響；4.化療后氣虛證、血虛證、陰虛證較化療前增加。
[Abstract]:This article includes two parts: literature review and clinical research. The first part is a literature review, mainly introduces the background of this research, that is, the relationship between malignant tumor and diabetes, mainly includes the following parts: 1: 1. The current research status of western medicine on malignant tumor with diabetes mellitus, including the basic concepts of cancer and diabetes, epidemiology, the pathogenesis of diabetes secondary malignant tumor, the possible mechanism of diabetes treatment drug secondary malignant tumor, The possible mechanism of diabetes secondary to malignant tumor and the effect of chemotherapy and other cancer treatment methods on blood sugar. The understanding of the etiology and pathogenesis of malignant tumor, the etiology and pathogenesis of diabetes, and the understanding of malignant tumor complicated with diabetes in TCM. The second part is clinical research on the effect of chemotherapy on blood sugar and TCM syndrome of breast cancer patients. Objective: to explore the following aspects: (1) the effect of chemotherapy on fasting blood glucose in patients with breast cancer; (2) the effect of chemotherapy on TCM syndromes of patients with breast cancer; (3) the related factors affecting fasting blood glucose after chemotherapy. Methods: by retrospective statistical analysis, 31 patients with breast cancer admitted from January 1, 2014 to December 31, 2014 in the Department of Oncology of Integrated Chinese and Western Medicine in Sino-Japanese Friendship Hospital were analyzed. The TCM syndromes and blood glucose before and after chemotherapy were analyzed. The influence of chemotherapy on blood sugar and TCM syndromes, as well as the correlation between chemotherapy scheme, basic blood sugar, age, liver function and blood glucose before and after chemotherapy were analyzed. The result is 1: 1. The blood glucose after chemotherapy was significantly higher than that before chemotherapy (P0.01). Basic fasting blood glucose, age, liver function and fasting blood glucose after chemotherapy were significantly different (P0.05). There was no significant difference in the effect of different chemotherapy regimens on fasting blood glucose after chemotherapy (P0.05). 4. Before chemotherapy, Qi stagnation syndrome, blood stasis syndrome, Qi deficiency syndrome, blood deficiency syndrome and yin deficiency syndrome were more than before chemotherapy. Conclusion 1. The blood glucose after chemotherapy was significantly higher than that before chemotherapy, and chemotherapy could lead to abnormal fasting blood glucose. Basic fasting blood glucose, age and liver function are related factors of fasting blood glucose after chemotherapy. Chemotherapy regimen had no effect on fasting blood glucose after chemotherapy. Qi deficiency syndrome, blood deficiency syndrome and yin deficiency syndrome increased after chemotherapy.
【學(xué)位授予單位】：北京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R737.9

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