本文選題：椎體脆性骨折 + 骨密度�。� 參考：《福建醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的:探討絕經(jīng)后婦女椎體脆性骨折的危險(xiǎn)因素及不同部位椎體脆性骨折的影響因子。方法:通過(guò)DXA(Dual-energy X-ray Absorptiometry,雙能X線骨密度儀)連續(xù)檢測(cè)274例50歲以上無(wú)癥狀絕經(jīng)后婦女腰椎(L1-L4)、股骨頸和全髖骨密度同時(shí),應(yīng)用VFA(Verterbral Fracture Assessment,椎體骨折評(píng)估軟件)發(fā)現(xiàn)椎體脆性骨折;收集所有受檢者一般資料。按照WHO骨質(zhì)疏松癥診斷標(biāo)準(zhǔn)將受檢者分為正常骨量組、低骨量組,骨質(zhì)疏松組。根據(jù)椎體骨折部位分為胸椎骨折組、腰椎骨折組、胸腰椎復(fù)合骨折組。結(jié)果:274例受檢者經(jīng)VFA檢查發(fā)現(xiàn)有103例椎體脆性骨折。1.單因素分析顯示年齡、絕經(jīng)年限、絕經(jīng)年齡及各部位BMD(Bone Mineral Density,骨密度)是絕經(jīng)后婦女椎體脆性骨折的可能影響因子(P0.05)。2.選擇單因素分析有統(tǒng)計(jì)學(xué)意義并經(jīng)共線性診斷的變量,進(jìn)一步行多因素二分類Logistic回歸分析顯示:絕經(jīng)年限及全髖BMD是椎體脆性骨折的危險(xiǎn)因素(P0.05)。3.不同部位椎體脆性骨折組比較:胸腰椎復(fù)合骨折組絕經(jīng)年限最長(zhǎng),股骨頸BMD及腰椎BMD最低;腰椎骨折組腰椎BMD較低;胸椎骨折組股骨頸BMD較低(P0.05);4.BMD聯(lián)合VFA骨質(zhì)疏松診斷率提高了7.3%(P0.05)。結(jié)論:絕經(jīng)年限增加、全髖BMD降低對(duì)絕經(jīng)后婦女椎體脆性骨折有重要的預(yù)測(cè)價(jià)值。絕經(jīng)年限、股骨頸BMD及腰椎BMD與不同部位椎體脆性骨折有關(guān)。對(duì)絕經(jīng)后婦女椎體脆性骨折的防治在重視骨密度的同時(shí)要聯(lián)合進(jìn)行椎體骨折評(píng)估,以提高椎體脆性骨折及骨質(zhì)疏松診斷率。
[Abstract]:Objective: to investigate the risk factors of brittle fracture of vertebral body in postmenopausal women and the influencing factors of brittle fracture of vertebral body in different parts. Methods: lumbar vertebrae (L1-L4), femoral neck and total hip density of 274 postmenopausal women over 50 years old were detected by DXA (Dual-energy X-ray absorptiometry). VFA (Verterbral fracture Assessment Software) was used to detect brittle fracture of vertebral body. Collect general information on all subjects. According to WHO diagnostic criteria of osteoporosis, the subjects were divided into normal bone mass group, low bone mass group and osteoporosis group. According to the position of vertebral fracture, it was divided into three groups: thoracic fracture group, lumbar vertebra fracture group and thoracolumbar complex fracture group. Results 103 cases of brittle fracture of vertebral body were found by VFA. Univariate analysis showed that age, menopausal age and bone mineral density (BMD) in postmenopausal women were the possible influencing factors of brittle fracture of postmenopausal women (P0.05). Multivariate logistic regression analysis showed that menopausal age and total hip BMD were risk factors of vertebral brittle fracture (P0.05). Comparison of different vertebral body brittle fracture group: thoracolumbar complex fracture group had the longest menopausal life, femoral neck BMD and lumbar BMD was the lowest; lumbar vertebrae fracture group had lower BMD of femur neck (P0.05). 4. The diagnosis rate of BMD combined with VFA osteoporosis in thoracic vertebral fracture group was increased by 7.3% (P0.05). Conclusion: the increase of menopausal life and the decrease of total hip BMD have important predictive value for postmenopausal women with brittle vertebral fracture. Menopausal period, femoral neck BMD and lumbar BMD were associated with brittle fracture of vertebral body. In order to improve the diagnostic rate of brittle fracture and osteoporosis in postmenopausal women, the prevention and treatment of brittle fracture of vertebral body should be combined with the evaluation of bone mineral density (BMD) in order to improve the diagnosis rate of brittle fracture of vertebral body and osteoporosis.
【學(xué)位授予單位】：福建醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R580;R687.3

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