本文選題：丙泊酚麻醉 + 異氟醚麻醉　； 參考：《重慶醫(yī)學》2017年17期

【摘要】：目的探討中腦腹側(cè)被蓋區(qū)(VTA)多巴胺神經(jīng)元在全身麻醉誘導(dǎo)和蘇醒中的作用。方法成年健康雄性SD大鼠40只,分為毀損組(n=20)和對照組(n=20),毀損組在雙側(cè)VTA給予特異性多巴胺神經(jīng)元毀損藥6-羥多巴胺(6-OHDA)減少多巴胺神經(jīng)元,對照組在雙側(cè)中腦腹側(cè)被蓋區(qū)給予等量生理鹽水。待手術(shù)后兩周,觀察在全身麻醉下,大鼠翻正反射消失時間(LORR)和恢復(fù)時間(RORR)。結(jié)果與對照組相比,在丙泊酚麻醉下可顯著縮短大鼠LORR(P0.05),且明顯延長大鼠RORR(P0.05)。在異氟醚麻醉下毀損組與對照組相比,大鼠LORR,差異無統(tǒng)計學意義(P0.05),但大鼠RORR延長(P0.05)。結(jié)論 VTA多巴胺神經(jīng)元在不同的全身麻醉藥的誘導(dǎo)和蘇醒發(fā)揮著有不同作用。
[Abstract]:Objective to investigate the role of VTA-dopaminergic neurons in the induction and recovery of general anesthesia in ventral tegmental area. Methods Forty adult male Sprague-Dawley rats were divided into two groups: the damage group (n = 20) and the control group (n = 20). The lesion group was treated with 6-hydroxydopamine 6-OHDA-reducing dopamine neuron in bilateral VTA. The control group was given the same amount of normal saline in bilateral ventral tegmental area. After two weeks of operation, we observed the time of disappearance of righting reflex (LORR) and recovery time (RORRV) under general anesthesia in rats. Results compared with the control group, propofol anesthesia could significantly shorten the LORRN P0.05A and prolong the RORRN P0.05U significantly. Compared with the control group, there was no significant difference of LORRin rats under isoflurane anesthesia, but the RORR was prolonged in rats. Conclusion VTA dopamine neurons play different roles in induction and recovery of different general anesthetics.
【作者單位】： 遵義醫(yī)學院麻醉系;
【基金】：國家自然科學基金資助項目(81560237)
【分類號】：R614.2

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1 李佳;vPAG多巴胺神經(jīng)元在丙泊酚麻醉中的作用機制研究[D];遵義醫(yī)學院;2016年

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