發(fā)布時間：2018-06-09 05:36

  本文選題：大骨節(jié)病 + 一氧化氮��； 參考：《中國地方病防治雜志》2017年02期

【摘要】：目的檢測青海成人大骨節(jié)病患者血清一氧化氮(NO)、腫瘤壞死因子-α(TNF-α)、白細胞介素-1β(IL-1β)和透明質(zhì)酸(HA)含量,探討NO、TNF-α、IL-1β和HA在青海大骨節(jié)病發(fā)生發(fā)展的機理。方法選擇青海省貴德和興�？h大骨節(jié)病區(qū)與西寧市非大骨節(jié)病區(qū)272例調(diào)查對象,分為大骨節(jié)病組(91)、病區(qū)對照組(92)、非病區(qū)對照組(89),平均年齡、性別無差別。采集靜脈血制備血清,用酶聯(lián)免疫吸附實驗(ELISA)檢測血清NO、TNF-α、IL-1β和HA含量。結(jié)果(1)3組間血清NO含量大骨節(jié)病組病區(qū)內(nèi)對照組病區(qū)外對照組(P0.05);(2)3組間血清TNF-α含量,大骨節(jié)病組和病區(qū)內(nèi)對照組病區(qū)外對照組(P0.05),但大骨節(jié)病組和病區(qū)內(nèi)對照組無顯著性差異(P0.05);(3)3組間血清IL-1β含量,大骨節(jié)病組和病區(qū)內(nèi)對照組病區(qū)外對照組(P0.05),但大骨節(jié)病組和病區(qū)內(nèi)對照組無顯著性差異(P0.05);(4)3組間血清HA含量,大骨節(jié)病組和病區(qū)內(nèi)對照組病區(qū)外對照組(P0.05),但大骨節(jié)病組和病區(qū)內(nèi)對照組無顯著性差異(P0.05)。結(jié)論青海成人大骨節(jié)病的發(fā)生發(fā)展與NO、TNF-α、IL-1β水平的升高和HA水平的降低有關(guān)。
[Abstract]:Objective to detect the levels of serum nitric oxide (no), tumor necrosis factor- 偽 (TNF- 偽), interleukin-1 尾 (IL-1 尾) and hyaluronic acid (HA) in patients with Kashin-Beck disease (KBD) in Qinghai province, and to explore the mechanism of the occurrence and development of KBD in Qinghai Province. Methods 272 cases of Kaschin-Beck disease (KBD) area in Guide and Xinghai County of Qinghai Province and non-KBD area in Xining City were divided into two groups: KBD group (n = 91), control group (n = 92) and control group (n = 89). There was no difference in average age and sex. Venous blood was collected to prepare serum and serum NONT-NF- 偽 IL-1 尾 and HA were detected by enzyme linked immunosorbent assay (Elisa). Results the level of serum no in KBD group was higher than that in control group (P 0.05) and TNF- 偽 content in serum between KBD group and KBD group. The levels of serum IL-1 尾 in KBD group and control group were not significantly different from those in KBD group and control group, but there was no significant difference in serum IL-1 尾 content between KBD group and KBD group, but there was no significant difference in serum IL-1 尾 content between KBD group and control group. However, there was no significant difference in serum HA content between KBD group and control group (P 0.05), but there was no significant difference in serum HA content between KBD group and control group (P 0.05), but there was no significant difference in serum HA content between KBD group and control group (P 0.05), but there was no significant difference in serum HA content between KBD group and control group. There was no significant difference in KBD group and control group, but there was no significant difference between KBD group and control group. Conclusion the occurrence and development of Kaschin-Beck disease in Qinghai is related to the increase of TNF- 偽 IL-1 尾 and the decrease of HA level.
【作者單位】： 青海省地方病預(yù)防控制所;
【基金】：青海省科技計劃項目(2014-ZJ-754)
【分類號】：R684.1
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本文編號：1999189