發(fā)布時間：2018-06-04 21:13

  本文選題：骨折 + 內固定　； 參考：《中國矯形外科雜志》2017年06期

【摘要】：[目的]觀察研究納米氮化鈦銀涂層髓內釘對家兔股骨骨折合并感染一期內固定的治療效果。[方法]健康青年級家兔16只,隨機分為納米氮化鈦組(Ti N)和納米氮化鈦銀組(Ti N-Ag),建立家兔開放骨折合并金黃色葡萄球菌感染模型,一期應用Ti N髓內釘和Ti N-Ag髓內釘固定,對比觀察兩組家兔術后感染、日�；顒�、體重、體溫等一般情況,定期拍攝X線片,術后8周取材進行微生物學和組織病理學檢查,評價新型納米氮化鈦銀涂層內固定材料的抗菌效果。[結果]術后8周,細菌培養(yǎng)結果提示Ti N組感染率為87.5%,Ti N-Ag組為25%(P=0.041);Ti N組動物體重平均增加(112.00±23.00)g,Ti N-Ag組增加(233.88±37.83)g,差異有統(tǒng)計學意義(P0.001);Ti NAg組體溫明顯低于Ti N組(P0.05)且波動較小;影像學檢查結果:Ti N組骨折斷端骨膜反應明顯,有死骨形成,內固定松動移位,Ti N-Ag組骨折斷段骨痂形成改建良好,內固定位置良好,未見明顯死骨形成;組織病理學觀察顯示:Ti N組大量炎性細胞聚集浸潤,Ti N-Ag組未見明顯死骨及炎性細胞浸潤。[結論]納米氮化鈦銀涂層髓內釘對骨折合并感染有良好的預防和治療效果,可有效降低術后感染風險。
[Abstract]:[objective] to observe the effect of titanium nitride silver coated intramedullary nail in the treatment of femoral fracture complicated with infection in rabbits. [methods] Sixteen healthy young rabbits were randomly divided into two groups: titanium nitride group (TiN) and silver nitride group (TiN-AgN). The open fracture model of rabbits with Staphylococcus aureus infection was established. The intramedullary nails and Ti N-Ag intramedullary nail were used in one stage. The infection, daily activity, body weight and body temperature of the two groups were observed. X-ray films were taken regularly. Microbiological and histopathological examinations were performed 8 weeks after operation. To evaluate the antibacterial effect of the new nano titanium nitride silver coating internal fixation material. [results] at 8 weeks after operation, the bacterial culture results showed that the infection rate of Ti N group was 87.5% and that of Ti N-Ag group was 25 N-Ag group. The average body weight increased by 112.00 鹵23.00 g Ti N-Ag group. The difference was statistically significant (P 0.001Ti NAg group was significantly lower than that of Ti N group P0.05) and the fluctuation was small. The results of imaging examination showed that the periosteum reaction at the broken end of fracture was obvious and the dead bone was formed in the 0: tin group. The fracture callus formation and remodeling were good in the group of loose fixation and displacement of Ti N-Ag, the position of internal fixation was good, and no obvious dead bone formation was found. Histopathological observation showed that there were no obvious dead bone and inflammatory cell infiltration in the Ti N-Ag group. [conclusion] Nano titanium nitride silver coated intramedullary nail has a good effect on prevention and treatment of fracture complicated infection, and can effectively reduce the risk of postoperative infection.
【作者單位】： 第四軍醫(yī)大學西京醫(yī)院骨科;南方醫(yī)科大學深圳醫(yī)院骨科;北京華鉭生物科技開發(fā)有限公司;
【基金】：西京醫(yī)院學科助推計劃(編號:XJZT14D01)
【分類號】：R687.33

【相似文獻】

相關期刊論文 前10條

1 曹曉明;侯志明;楚明;;鍍氮化鈦膜釹鐵硼磁體細胞毒性的實驗研究[J];上�？谇会t(yī)學;2008年02期

2 鄭曉輝，，鄧春富，楊彥昌;氮化鈦—鈦陶瓷復合體頜骨內種植的動物實驗研究[J];中國醫(yī)科大學學報;1995年01期

3 熊美萍,蔡玉惠,光寒冰;金屬鈦輝光離子氮化制備氮化鈦膜層的研究[J];口腔醫(yī)學;2005年05期

4 董何彥,潘巨利,李永福,周敬黨;L_(316)氮化鈦不銹鋼復合體脛骨內種植的動物實驗研究[J];大連大學學報;1999年02期

5 劉杰;時磊;范金杰;葛亞麗;谷曉明;;氮化鈦涂層和黏結瓷對鈦瓷結合強度的影響[J];中國組織工程研究;2012年43期

6 尹路;肖云;林W

本文編號：1978845