本文選題：鎮(zhèn)痛 + 硬膜外��； 參考：《浙江大學(xué)》2015年碩士論文

【摘要】：目的： 本課題旨在研制一種具有抗感染功能的硬膜外-皮下埋藏式鎮(zhèn)痛泵,評(píng)價(jià)其抗感染性能。 方法： 設(shè)計(jì)具有抗感染功能的硬膜外-皮下埋藏式鎮(zhèn)痛泵的圖紙。其主要部件皮下埋藏式注藥壺,采用堇青石多微孔陶瓷內(nèi)膽,微孔孔徑通過(guò)粘土粉體與醫(yī)用石蠟以質(zhì)量比調(diào)節(jié)。 采用化學(xué)還原的方法,以硼氫化鈉為還原劑,殼聚糖為穩(wěn)定劑,在硝酸銀溶液內(nèi)制備殼聚糖/納米銀復(fù)合溶液。堇青石陶瓷內(nèi)膽表面定量負(fù)載原位法生成的殼聚糖/納米銀抗菌涂層。 對(duì)殼聚糖/納米銀抗菌涂層的堇青石進(jìn)行抗大腸桿菌和金黃色葡萄球菌的體外抑菌試驗(yàn),分別用原位生成法和外加納米銀液制備殼聚糖/納米銀抗菌涂層,定量負(fù)載到濾紙片和堇青石樣品上,觀察體外抑菌效果；同時(shí)行抑菌持續(xù)時(shí)間檢測(cè),將殼聚糖/納米銀抗菌涂層的濾紙片和堇青石樣品分別浸泡于磷酸緩沖鹽溶液,三蒸水和10%嗎啡溶液中30天后取出,測(cè)試其耐水洗性和抗菌性能(抑菌帶)。每次試驗(yàn)均重復(fù)3次。 結(jié)果： 成功設(shè)計(jì)了具有抗感染功能的硬膜外-皮下埋藏式鎮(zhèn)痛泵的圖紙。其主要部件皮下埋藏式注藥壺,采用堇青石多微孔陶瓷內(nèi)膽,微孔孔徑可調(diào)節(jié),當(dāng)粘土粉體與醫(yī)用石蠟為100：13時(shí),所得陶瓷內(nèi)膽的孔隙率約為26.4%,最可幾孔徑尺寸為Φ6.6μm。 體外抑菌試驗(yàn)顯示,本研究使用的原位生成法相比于外加納米銀法能夠有效增強(qiáng)納米銀抗菌效果,使得殼聚糖／納米銀抗菌涂層抗菌能力更強(qiáng)；殼聚糖／納米銀涂層的堇青石具有良好的抗大腸桿菌和金黃色葡萄球菌效果；且有一定的耐水洗效果,抑菌持續(xù)時(shí)間至少可達(dá)30天。 結(jié)論： 本課題成功研制了一種具有良好抗感染功能的硬膜外-皮下埋藏式鎮(zhèn)痛泵。體外實(shí)驗(yàn)結(jié)果表明殼聚糖／納米銀涂層的堇青石多微孔陶瓷內(nèi)膽抑菌持續(xù)時(shí)間至少可達(dá)30天,能有效預(yù)防硬膜外導(dǎo)管長(zhǎng)期留置引起的相關(guān)感染。
[Abstract]:Objective: The purpose of this paper is to develop an anti-infective epidural-subcutaneous analgesic pump and evaluate its anti-infection performance. Methods: Design the drawing of epidural-subcutaneous analgesic pump with anti-infection function. The main component of the pot is subcutaneously implanted. Cordierite multiporous ceramic inner bile is used. The pore diameter of cordierite is adjusted by the mass ratio of clay powder to medical paraffin. Chitosan / nano-silver composite solution was prepared in silver nitrate solution by chemical reduction with sodium borohydride as reducing agent and chitosan as stabilizer. Chitosan / nano silver antibacterial coating prepared by quantitative loading on cordierite ceramic inner bile surface. In vitro bacteriostatic tests were carried out on cordierite coated with chitosan / nano-silver antibacterial coating against Escherichia coli and Staphylococcus aureus. Chitosan / nano-silver antibacterial coating was prepared by in-situ formation and addition of nano-silver solution, respectively. The bacteriostatic effect was observed by loading the filter paper and cordierite sample quantitatively, and the bacteriostatic duration was determined. The filter paper and cordierite sample of chitosan / nano-silver antibacterial coating were immersed in phosphate buffer solution, respectively. The three distilled water and 10% morphine solution were taken out after 30 days to test their washability and antimicrobial activity. Each trial was repeated 3 times. Results: The drawing of epidural-subcutaneous analgesic pump with anti-infection function was successfully designed. The main component of the pot is subcutaneously implanted, and cordierite multi-porous ceramic inner bile is used. The pore size of the ceramic is adjustable. When the ratio of clay powder and medical paraffin is 100: 13, the porosity of ceramic inner bile is about 26.4 and the most likely pore size is 桅 6.6 渭 m. The bacteriostatic test in vitro showed that the in-situ formation method used in this study could effectively enhance the antibacterial effect of nano-silver and make the antibacterial ability of chitosan / nano-silver antibacterial coating stronger than the addition of nano-silver method. The cordierite coated with chitosan / nano-silver has good resistance to Escherichia coli and Staphylococcus aureus, and has a certain anti-washing effect, and the bacteriostatic duration can reach at least 30 days. Conclusion: A kind of epidural-subcutaneous analgesic pump with good anti-infection function has been successfully developed. The results showed that the bacteriostatic time of cordierite microporous ceramic coated with chitosan / nano-silver coating was at least 30 days, which could effectively prevent the infection caused by long-term indwelling of epidural catheter.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：R614

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