本文選題：硅凝膠 + 增生　； 參考：《中國(guó)皮膚性病學(xué)雜志》2017年01期

【摘要】：目的評(píng)價(jià)硅凝膠治療增生性瘢痕的有效性及安全性。方法計(jì)算機(jī)檢索Cochrane圖書館臨床對(duì)照試驗(yàn)數(shù)據(jù)庫(kù)、MEDLINE光盤數(shù)據(jù)庫(kù)、相關(guān)期刊論文及萬方數(shù)據(jù)庫(kù)。篩選應(yīng)用硅凝膠治療增生性瘢痕,對(duì)照組為空白或安慰劑的隨機(jī)或臨床對(duì)照試驗(yàn),使用Cochrane協(xié)作網(wǎng)提供的Rev Man 5.0軟件對(duì)納入文獻(xiàn)進(jìn)行統(tǒng)計(jì)分析。主要評(píng)價(jià)指標(biāo)為瘢痕厚度,次要指標(biāo)包括瘢痕彈性、顏色、并發(fā)癥發(fā)生率及疼痛和瘙癢等。結(jié)果硅凝膠治療在縮小瘢痕厚度[RR=-1.62,95%CI=(-2.70,-0.55),P=0.003],改善瘢痕顏色[RR=2.17,95%CI=(1.09,4.35),P=0.03]及疼痛和瘙癢等[RR=3.00,95%CI=(1.19,7.54),P=0.02]方面優(yōu)于對(duì)照組,但其對(duì)瘢痕彈性改善與對(duì)照組差異無統(tǒng)計(jì)學(xué)意義[RR=3.03,95%CI=(1.02,8.99),P=0.05],且其并發(fā)癥發(fā)生率較對(duì)照組高[RR=9.21,95%CI=(2.6,32.67),P=0.000 6]。結(jié)論硅凝膠在改善增生性瘢痕厚度、顏色及患者主觀評(píng)價(jià)方面可能具有一定的療效,但在改善瘢痕彈性方面并無顯著療效,且并發(fā)癥發(fā)生率高于對(duì)照組。本次研究由于納入的研究質(zhì)量普遍不高,結(jié)果存在一定的偏倚性,尚不能得出硅凝膠對(duì)增生性瘢痕療效優(yōu)于對(duì)照組的結(jié)論。
[Abstract]:Objective to evaluate the efficacy and safety of silicone gel in the treatment of hypertrophic scar. Methods the Cochrane library clinical controlled trial database was searched by computer, including MEDLINE CD-ROM database, Chinese periodical full-text database and Wanfang database. Silica gel was used to treat hypertrophic scar. The control group was a blank or placebo randomized or clinical controlled trial. The statistical analysis of the literature was carried out using Rev Man 5.0 software provided by Cochrane cooperation network. The main evaluation measures were scar thickness, and the secondary indexes included scar elasticity, color, incidence of complications, pain and pruritus. 緇撴灉紜呭嚌鑳舵不鐤楀湪緙╁皬鐦㈢棔鍘氬害[RR=-1.62,95%CI=(-2.70,-0.55),P=0.003],鏀瑰杽鐦㈢棔棰滆壊[RR=2.17,95%CI=(1.09,4.35),P=0.03]鍙?qiáng)鐤肩棝鍜岀槞鐥捊{塠RR=3.00,95%CI=(1.19,7.54),P=0.02]鏂歸潰浼樹簬瀵圭収緇，

本文編號(hào)：1956731