本文選題：鈦 + 合金��； 參考：《中國(guó)組織工程研究》2017年02期

【摘要】：背景:以鈦合金為基底進(jìn)行表面改性進(jìn)一步提高其表面生物活性是目前研究的熱點(diǎn),而摻鍶改性是提高植入物骨整合性的有效手段。目的:介紹以醫(yī)用鈦合金為基底摻鍶改性的研究進(jìn)展。方法:以"鈦合金,鍶,骨組織,成骨"為中文檢索詞,以"titanium(ti),strontium(sr),bone,osteogenic"為英文檢索詞,在中國(guó)知網(wǎng)和Pub Med數(shù)據(jù)庫(kù)檢索2000年1月至2016年4月期間有關(guān)醫(yī)用鈦合金摻鍶改性方面的文獻(xiàn)。結(jié)果與結(jié)論:1醫(yī)用鈦合金具有較好的生物相容性,且與人體骨彈性模量接近,因而廣泛應(yīng)用于臨床骨修復(fù)的植入物;2單純鈦合金表面生物活性較差,難以和骨組織結(jié)合達(dá)到骨整合;3對(duì)鈦合金進(jìn)行表面功能改性是行之有效的方案,而摻鍶改性可顯著促進(jìn)新骨生成,達(dá)到骨與鈦合金的整合;4目前摻鍶改性的鈦合金植入物及支架材料大多還處于體外實(shí)驗(yàn)和動(dòng)物實(shí)驗(yàn)階段,快速、穩(wěn)定、易獲得且安全有效的改性方法仍需進(jìn)一步研究。
[Abstract]:Background: surface modification based on titanium alloy is a hot topic in recent years, and strontium doping is an effective method to improve the bone integrity of implants. Objective: to introduce the progress of strontium-doped modification of medical titanium alloy. Methods: "Titanium alloy, strontium, bone tissue, osteogenesis" was used as Chinese key word, and "titaniumtiumsstrontiumn" as English key word. Literature on the modification of medical titanium alloy doped with strontium between January 2000 and April 2016 was searched in China and Pub Med database. Results the titanium alloy has good biocompatibility and is close to the elastic modulus of human bone, so the surface bioactivity of the pure titanium alloy widely used in clinical bone repair is poor. It is an effective method to modify the surface function of titanium alloy which is difficult to combine with bone tissue to achieve bone integration, while strontium doping can significantly promote the formation of new bone. To achieve the integration of bone and titanium alloy at present, most of the Sr-doped titanium alloy implants and scaffolds are still in the stage of in vitro and animal experiments. The modification methods which are fast, stable, easy to obtain and safe and effective still need to be further studied.
【作者單位】： 吉林大學(xué)第二醫(yī)院;
【基金】：吉林省省級(jí)產(chǎn)業(yè)專(zhuān)業(yè)創(chuàng)新專(zhuān)項(xiàng)資金項(xiàng)目(2016C037) 吉林省科技發(fā)展計(jì)劃項(xiàng)目(20150414006G H)~~
【分類(lèi)號(hào)】：R318.08;R687

【參考文獻(xiàn)】

相關(guān)期刊論文 前4條

1 劉茂林;張晶;陳峗;何福明;王小祥;;鈦表面電化學(xué)法制備摻鍶羥基磷灰石涂層及其形貌控制[J];材料科學(xué)與工程學(xué)報(bào);2016年01期

2 陳齊勇;梁s昵，

本文編號(hào)：1919122