本文選題：創(chuàng)傷患者 + 創(chuàng)面　； 參考：《中華醫(yī)院感染學雜志》2017年12期

【摘要】：目的了解創(chuàng)傷患者創(chuàng)面標本腸桿菌科細菌分布與耐藥性變遷。方法收集2012-2016年醫(yī)院各科患者傷口標本分離出腸桿菌科細菌1 757株,采用Phoenix-100全自動細菌鑒定藥敏系統(tǒng)進行鑒定并測定MIC,結(jié)果參照美國臨床和實驗室標準化協(xié)會(CLSI)標準判斷。WHONET5.6和SPSS20.0軟件對實驗結(jié)果進行統(tǒng)計分析。結(jié)果創(chuàng)傷患者創(chuàng)面標本分離腸桿菌科細菌以大腸埃希菌、陰溝腸桿菌和肺炎克雷伯菌為主,分別占58.61%、21.48%和7.25%;其對頭孢唑林、四環(huán)素、磺胺甲VA唑/甲氧芐啶、氨芐青霉素、氨芐西林/舒巴坦、哌拉西林、頭孢呋辛等抗菌藥物的耐藥率較高;對阿米卡星、哌拉西林/他唑巴坦、亞胺培南和美羅培南等耐藥率較低;對左氧氟沙星、阿米卡星、環(huán)丙沙星、慶大霉素、妥布霉素等氨基糖甙類和喹諾酮類抗菌藥物的耐藥率顯下降趨勢(P0.05);對頭孢唑林、阿莫西林/克拉維酸、頭孢西丁、哌拉西林/他唑巴坦等青霉素類、頭孢菌素類和頭霉素類及含酶抑制劑抗菌藥物的耐藥率呈上升趨勢(P0.05)。結(jié)論創(chuàng)傷患者創(chuàng)面感染腸桿菌科細菌的耐藥性快速上升,得到了一定控制,但對部分常用抗菌藥物仍現(xiàn)上升趨勢,應繼續(xù)采取有效控制措施。
[Abstract]:Objective to investigate the distribution and drug resistance of Enterobacteriaceae in wound wound specimens. Methods A total of 1,757 strains of Enterobacteriaceae bacteria were isolated from wound specimens from patients in hospitals from 2012 to 2016. Phoenix-100 automatic bacterial identification system was used to identify and determine the drug sensitivity. The results were statistically analyzed with reference to the American Association for Clinical and Laboratory Standardization (ACLSI) standard. WHONET5.6 and SPSS20.0 software. Results Enterobacteriaceae bacteria were mainly Escherichia coli, Enterobacter cloacae and Klebsiella pneumoniae, accounting for 21.48% and 7.25%, respectively, for cefazolin, tetracycline, sulfamethazol / trimethoprim, ampicillin. Ampicillin / sulbactam, piperacillin, cefuroxime and other antimicrobial agents have higher drug resistance; low resistance to amikacin, piperacillin / tazobactam, imipenem and meropenem; levofloxacin, amikacin, The resistance rates of ciprofloxacin, gentamycin, tobramycin and quinolones were significantly decreased (P 0.05), and penicillin such as cefazolin, amoxicillin / clavulanic acid, cefxitin, piperacillin / tazobactam, etc. The resistance rate of cephalosporins, cephalomycin and antimicrobial agents containing enzyme inhibitors showed an increasing trend (P 0.05). Conclusion the drug resistance of Enterobacteriaceae bacteria in wound wound infection has been rapidly increased and controlled to some extent, but some commonly used antimicrobial agents are still on the rise, and effective control measures should continue to be taken.
【作者單位】： 貴州醫(yī)科大學第三附屬醫(yī)院感染管理科;貴州省人民醫(yī)院感染管理科;貴州醫(yī)科大學第三附屬醫(yī)院檢驗科;
【基金】：貴州省科技廳聯(lián)合基金資助項目(黔科合LH字[2014]7162) 貴州省黔南州社會發(fā)展科技基金資助項目(黔南科合社字[2013]20)
【分類號】：R641
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本文編號：1814120