發(fā)布時間：2018-04-18 19:10

  本文選題：肌少癥 + 非小細胞肺癌　； 參考：《山東醫(yī)藥》2017年46期

【摘要】：目的探討肌少癥(SAR)對早期非小細胞肺癌(NSCLC)患者術后遠期預后的影響。方法選擇2011年1月~2014年12月行手術治療的早期NSCLC患者212例,根據(jù)SAR診斷標準診斷是否存在SAR。記錄并比較有、無SAR患者的臨床病理資料,包括性別、年齡、BMI、合并癥、吸煙史,術前血清癌胚抗原(CEA)、C反應蛋白(CRP)、白蛋白水平、手術相關情況、病理情況、術后放化療情況。對所有患者進行長期隨訪,時間截止2016年12月31日,起點事件為手術,終點事件為死亡(全死因),記錄患者隨訪期間的死亡、復發(fā)情況。采用Kaplan-Meier法估算生存率,采用log-rank檢驗比較生存率曲線差異,采用多變量Cox比例風險回歸分析死亡和復發(fā)的影響因素。結果共診斷SAR 92例,占全部患者的43.4%(92/212)。與無SAR患者相比,SAR患者中女性比例較高、年齡較大、BMI和術前血清白蛋白水平較低、術前血清CRP水平較高(P0.05或0.01)。隨訪時間42(6~69)個月,無SAR患者的生存時間長于SAR患者(χ2=4.040,P=0.044)。多因素分析顯示,年齡68歲、合并心血管疾病、病理分期Ⅱ期、高中分化程度和SAR均為死亡的危險因素(P均0.05)。無SAR患者的無復發(fā)生存時間長于SAR患者(χ2=4.703,P=0.030)。多因素分析顯示,血管浸潤、病理分期Ⅱ期、高中分化程度、放化療和SAR均為復發(fā)的危險因素(P均0.05)。結論存在SAR時可明顯縮短NSCLC患者術后的生存時間及無復發(fā)時間,是導致NSCLC患者術后死亡及復發(fā)的危險因素。
[Abstract]:Objective to investigate the long-term prognosis of patients with early non-small cell lung cancer (NSCLC).Methods 212 early NSCLC patients who underwent surgical treatment from January 2011 to December 2014 were selected and diagnosed according to the diagnostic criteria of SAR.The clinicopathological data of patients without SAR were recorded and compared, including sex, age, complication, smoking history, preoperative serum carcinoembryonic antigen (CEA) CEA C reactive protein (CRP), albumin level, surgical status, pathology, postoperative radiotherapy and chemotherapy.All patients were followed up for a long period of time, until December 31, 2016, the starting event was surgery, and the end event was death (all cause of death, record the death and recurrence of the patient during the follow-up period).Kaplan-Meier method was used to estimate the survival rate, log-rank test was used to compare the difference of survival curve, and multivariate Cox proportional risk regression analysis was used to analyze the influencing factors of death and recurrence.Results 92 cases of SAR were diagnosed, accounting for 43.4% of all patients.Compared with the patients without SAR, the proportion of females was higher, the serum albumin levels and serum CRP levels were lower in older women than those in patients without SAR, and the preoperative CRP levels were higher (P0.05 or 0.01).The survival time of the patients without SAR was longer than that of the patients with SAR (蠂 2 4.040 P < 0.044).Multivariate analysis showed that age 68 years old, complicated with cardiovascular disease, pathological stage 鈪，

本文編號：1769672