經(jīng)導(dǎo)管自膨式和球囊擴(kuò)張式主動(dòng)脈人工瓣膜置入術(shù)療效比較的Meta分析
本文選題:自膨式主動(dòng)脈瓣膜 切入點(diǎn):球囊擴(kuò)張式主動(dòng)脈瓣膜 出處:《實(shí)用醫(yī)學(xué)雜志》2017年04期
【摘要】:目的:比較自膨式主動(dòng)脈瓣膜(SEv)和球囊擴(kuò)張式主動(dòng)脈瓣膜(BEv)經(jīng)導(dǎo)管主動(dòng)脈瓣膜置入術(shù)(TAVI)的療效及安全性,為臨床治療提供循證學(xué)依據(jù)。方法:檢索Pubmed、CNKI和萬方數(shù)據(jù)庫,檢索所有比較經(jīng)導(dǎo)管SEv和BEv人工瓣膜置入術(shù)療效的對照研究。統(tǒng)計(jì)分析30 d的病死率、中重度主動(dòng)脈瓣返流(AR)、心臟起搏器植入率及隨訪1年的總體病死率,并采用Rev Man5.2和Stata11軟件進(jìn)行Meta分析。結(jié)果:最終納入6項(xiàng)研究(1項(xiàng)為隨機(jī)對照研究,5項(xiàng)為回顧性研究),共1 805例患者。分析結(jié)果顯示,SEv置入術(shù)的中重度主動(dòng)脈瓣返流率及心臟起搏器植入率均明顯高于球囊擴(kuò)張式瓣膜置入術(shù)(OR=3.01,P0.000 1;OR=4.13,P0.000 01),而二者的瓣膜置入術(shù)成功率、血管并發(fā)癥發(fā)生率、30 d及1年病死率則無明顯差異(P0.05)。結(jié)論:經(jīng)導(dǎo)管SEv置入術(shù)中重度主動(dòng)脈瓣返流率及心臟起搏器植入率風(fēng)險(xiǎn)高于BEv置入術(shù),但二者的手術(shù)成功率、術(shù)后血管并發(fā)癥發(fā)生率及中短期死亡率則無明顯差異。
[Abstract]:Objective: to compare the efficacy and safety of self-expandable aortic valvus (SEV) and balloon dilated aortic valve (BEvV) via catheterized aortic valve implantation (TAVI), and to provide evidence based basis for clinical treatment.Methods: the database of Pubmedus Sinica and Wanfang were searched, and all the comparative studies were conducted to compare the efficacy of transcatheter SEv and BEv prosthetic valve implantation.The mortality of 30 days, moderate and severe aortic regurgitation, cardiac pacemaker implantation rate and overall fatality rate of 1 year follow up were analyzed statistically. Meta was analyzed by Rev Man5.2 and Stata11 software.Results: a total of 1 805 patients were included in 6 studies, including 1 randomized controlled study and 5 retrospective studies.The results showed that the moderate and severe aortic regurgitation rate and pacemaker implantation rate in SEV implantation were significantly higher than those in ORV 3.01 P 0.000 1 P 0.13 P 0.000 01, and the successful rate of valve implantation in both groups was higher than that in the balloon dilated valve implantation.There was no significant difference in the incidence of vascular complications between 30 days and 1 year (P 0.05).Conclusion: the risk of severe aortic regurgitation rate and pacemaker implantation rate in transcatheter SEv implantation is higher than that in BEv implantation, but there is no significant difference in the success rate, the incidence of postoperative vascular complications and the medium and short term mortality between the two groups.
【作者單位】: 河南科技大學(xué)臨床醫(yī)學(xué)院河南科技大學(xué)第一附屬醫(yī)院心外科;
【分類號(hào)】:R654.2
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