本文選題：椎間盤　切入點：脊索　出處：《東南大學學報(醫(yī)學版)》2017年06期

【摘要】：椎間盤退變是腰背痛的主要原因,研究椎間盤發(fā)育、退變,結(jié)構(gòu)功能以及椎間盤中各種細胞的特異性標志物有助于椎間盤疾病的治療。近年來的研究發(fā)現(xiàn),椎間盤起源于脊索,椎間盤退變始于髓核細胞類型和數(shù)量的改變,同時也伴隨著纖維環(huán)細胞和終板軟骨細胞的改變。髓核細胞有相對系統(tǒng)的標志物,而纖維環(huán)細胞和終板軟骨細胞尚無明確的標志物。作者就椎間盤的生物學特征以及椎間盤內(nèi)各種細胞標志物的研究進展作一綜述。
[Abstract]:Disc degeneration is the main cause of low back pain. The study of disc development degeneration structure and function as well as the specific markers of various cells in intervertebral disc is helpful to the treatment of intervertebral disc disease.In recent years, it has been found that the disc originated from the spinal cord, and the degeneration of the intervertebral disc began with the changes of the type and quantity of nucleus pulposus cells, as well as the changes of fibroannular cells and endplate chondrocytes.There are relatively systematic markers in nucleus pulposus cells, but there are no clear markers in fibroannular cells and endplate chondrocytes.This paper reviews the biological characteristics of intervertebral disc and the progress of various cellular markers in intervertebral disc.
【作者單位】： 東南大學醫(yī)學院;東南大學附屬中大醫(yī)院脊柱外科;
【基金】：國家自然科學基金資助項目(81572170)
【分類號】：R681.53
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本文編號：1700959