本文選題：肺功能　切入點(diǎn)：深低溫停循環(huán)　出處：《山東醫(yī)藥》2017年39期

【摘要】：目的觀察心臟外科手術(shù)深低溫停循環(huán)時(shí)間對(duì)患者肺功能及血清炎癥因子水平的影響。方法進(jìn)行體外循環(huán)心臟外科手術(shù)治療的患者40例,根據(jù)停循環(huán)時(shí)間不同分為觀察組和對(duì)照組各20例。對(duì)照組中低溫體循環(huán)術(shù)中深低溫停循環(huán)時(shí)間≥40 min,觀察組深低溫停循環(huán)時(shí)間40 min。分別于手術(shù)前后檢測(cè)兩組患者的肺功能指標(biāo)用力肺活量[(FVC%)、1秒用力呼氣容積(FEV1%)]及炎癥因子指標(biāo)(hs-CRP、IL-6、TNF-α)。結(jié)果兩組患者術(shù)后FVC%、FEV1%較術(shù)前降低,但觀察組高于對(duì)照組(P均0.05)。兩組術(shù)后血IL-6、TNF-α、hs-CRP水平較術(shù)前降低,且觀察組低于對(duì)照組(P均0.05)。結(jié)論中低溫體外循環(huán)術(shù)中深低溫停循環(huán)時(shí)間40 min較≥40 min能夠有效減輕肺損傷,減輕炎癥反應(yīng)。
[Abstract]:Objective to observe the effect of deep hypothermia circulatory arrest time on pulmonary function and serum inflammatory factor level in patients undergoing cardiopulmonary bypass (CPB). According to the time of circulatory arrest, the patients in the control group were divided into two groups: the control group (n = 20) and the control group (n = 20). The deep hypothermic circulatory arrest time in the control group was more than 40 min, and that in the observation group was 40 min. The two groups were examined before and after operation. Objective: forced vital capacity (FVC1) and inflammatory cytokines (hs-CRPIL-6, TNF- 偽) were measured. Results the FEV1% of patients in the two groups were decreased after operation. However, the levels of serum IL-6 TNF- 偽 hs-CRP in the observation group were lower than those in the control group, and the levels of serum IL-6 TNF- 偽 hs-CRP in the observation group were lower than those in the control group (P < 0.05). Conclusion the deep hypothermia cardiopulmonary bypass duration of 40 min during moderate hypothermia cardiopulmonary bypass is more effective than that of 鈮，

本文編號(hào)：1671717