本文選題：老年人　切入點(diǎn)：肌肉衰減綜合征　出處：《鄭州大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的探索補(bǔ)充維生素D、維生素E和乳清蛋白對肌肉衰減綜合征老年人肌肉質(zhì)量、功能和強(qiáng)度的影響。方法于2015年10月至2016年1月期間,選取鄭州市上街區(qū)具有良好溝通能力,無已知身體或精神疾病的60歲及以上老年人進(jìn)行肌肉衰減綜合征篩查。共60名肌肉衰減綜合征患者納入本研究。采用計(jì)算機(jī)生成的隨機(jī)數(shù)字,以性別、年齡做匹配,將研究對象分為干預(yù)組和安慰劑組,每組30人,干預(yù)組給予乳清蛋白聯(lián)合制劑,每日兩次,每次20g。安慰劑組給予等能量、等重量安慰劑,其服用方法與干預(yù)組相同。干預(yù)6個月,期間受試者保持平時的生活和飲食習(xí)慣,每一個月隨訪一次。在干預(yù)開始前和干預(yù)結(jié)束后分別測量研究對象的相對骨骼肌質(zhì)量指數(shù),握力,6-m步行時間,起立走計(jì)時,椅上坐站試驗(yàn),營養(yǎng)狀況,生活質(zhì)量,血清學(xué)指標(biāo)。采用頻數(shù)(構(gòu)成比)、均數(shù)±標(biāo)準(zhǔn)差對基線資料進(jìn)行描述性統(tǒng)計(jì)。采用協(xié)方差分析比較兩組干預(yù)前后相對骨骼肌質(zhì)量指數(shù)和握力變化是否存在差異;采用獨(dú)立樣本t檢驗(yàn)比較干預(yù)前后兩組6-m步行時間,起立走計(jì)時,椅上坐站試驗(yàn),四肢骨骼肌含量,生活質(zhì)量和血清生化指標(biāo)變化是否有差異。結(jié)果結(jié)果顯示干預(yù)組四肢骨骼肌含量變化值為0.23±1.07 kg,安慰劑組變化值為-0.25±0.71 kg,差異具有統(tǒng)計(jì)學(xué)意義(P=0.043)。干預(yù)組握力變化值為1.9±4.24kg,安慰劑組變化值為-0.88±3.20 kg,差異有統(tǒng)計(jì)學(xué)意義(P=0.006);干預(yù)組相對骨骼肌質(zhì)量指數(shù)變化值為0.08±0.38 kg/m2,安慰劑組變化值為-0.13±0.31kg/m2,差異具有統(tǒng)計(jì)學(xué)意義(P=0.021);干預(yù)組6-m步行時間變化值為-1.01±1.50 s,安慰劑組變化值為-0.02±5.17 s,差異無統(tǒng)計(jì)學(xué)意義(P=0.312)。干預(yù)后干預(yù)組血清甘油三脂變化值為-0.23±0.52 mmol/L,安慰劑組變化值為0.01±0.41 mmol/L,差異有統(tǒng)計(jì)學(xué)意義(P=0.046);干預(yù)組胰島素樣生長因子-1變化值為14.18±28.33ng/m L,安慰劑組變化值為-1.13±17.96 ng/m L,差異具有統(tǒng)計(jì)學(xué)意義(P=0.015);干預(yù)組白介素-2變化值為40.17±487.18 pg/m L,安慰劑組變化值為633.3±1362.27 pg/m L,差異具有統(tǒng)計(jì)學(xué)意義(P=0.029)。干預(yù)后干預(yù)組生活質(zhì)量明顯改善,干預(yù)軀體維度綜合變化值為17.39±16.92,安慰劑組變化值為-2.28±17.01,差異有統(tǒng)計(jì)學(xué)意義(P0.001);干預(yù)組心理維度綜合變化值為12.98±13.70,安慰劑組變化值為2.20±14.23,差異具有統(tǒng)計(jì)學(xué)意義(P=0.004)。結(jié)論(1)聯(lián)合補(bǔ)充乳清蛋白、維生素D和E可以改善肌肉衰減綜合征患者肌肉質(zhì)量和力量。(2)聯(lián)合補(bǔ)充乳清蛋白、維生素D和E可以改善肌肉衰減綜合征患者生活質(zhì)量。(3)聯(lián)合補(bǔ)充乳清蛋白、維生素D和E可以改善肌肉衰減綜合征患者血清甘油三脂、胰島素樣生長因子-1、白介素-2水平。
[Abstract]:Objective to explore the effects of vitamin D, vitamin E and whey protein supplementation on muscle quality, function and strength in elderly patients with muscular attenuation syndrome. A total of 60 patients with muscular attenuating syndrome were enrolled in this study. A total of 60 patients with muscular attenuation syndrome were enrolled in the study. Random numbers were generated by computer and matched by sex and age. Participants were divided into intervention group and placebo group, 30 people in each group. The intervention group was given whey protein combined preparation twice a day, 20g. placebo group was given equal energy and equal weight placebo. The method was the same as that in the intervention group. After 6 months of intervention, the subjects maintained their normal living and eating habits, followed up once a month. The relative skeletal muscle mass index of the subjects was measured before and after the intervention. Grip strength 6-m walking time, standing time, chair sitting test, nutritional status, quality of life, The baseline data were analyzed by frequency (composition ratio, mean 鹵standard deviation). Covariance analysis was used to compare whether there were differences in relative skeletal muscle mass index and grip strength between the two groups before and after intervention. T test was used to compare 6-m walking time, standing time, chair sitting test and skeletal muscle content in the two groups before and after intervention. The results showed that the change value of skeletal muscle content in the intervention group was 0.23 鹵1.07 kg, the change value in the placebo group was -0.25 鹵0.71 kg, the difference was statistically significant. The change value of grip strength in the intervention group was 0.23 鹵1.07 kg and that in the placebo group was -0.25 鹵0.71 kg, respectively. 1.9 鹵4.24 kg, -0.88 鹵3.20 kg in placebo group, 0.08 鹵0.38 kg / m2 in intervention group and -0.13 鹵0.31 kg / m ~ (2) in placebo group, and 6-m walking time in intervention group were -1.01 鹵1.50 kg / m ~ (-2), respectively, the difference was statistically significant (P < 0.05), and that of intervention group was -1.01 鹵1.50 kg 路m ~ (-2), that of placebo group was -0.13 鹵0.31 kg / m ~ (-2), and that of intervention group was -1.01 鹵1.50 kg 路m ~ (-2). After intervention, the change of serum triglyceride was -0.23 鹵0.52 mmol / L, and that of placebo group was 0.01 鹵0.41 mmol / L, the difference was statistically significant (P0.046), while that of intervention group was -0.23 鹵0.52 mmol / L (P < 0.05), and that of placebo group was 0.01 鹵0.41 mmol / L (P < 0.05). The value of interleukin-2 in the intervention group was 40.17 鹵487.18 pg/m / L, and the value in the placebo group was 633.3 鹵1362.27 pg/m / L, the difference was statistically significant (P0.0299.The quality of life in the intervention group was significantly improved after the intervention, and the change value of the placebo group was -1.13 鹵17.96 ng/m / L, P < 0.05), the difference was statistically significant (P < 0.05), and that of the intervention group was 40.17 鹵487.18 pg/m / L and 633.3 鹵1362.27 pg/m / L, respectively. The comprehensive change value of somatic dimension in intervention group was 17.39 鹵16.92, that in placebo group was -2.28 鹵17.01, the difference was statistically significant (P 0.001), the psychological dimension of intervention group was 12.98 鹵13.70, the change value of placebo group was 2.20 鹵14.23, the difference was statistically significant (P0.0044.Conclusion 1). Vitamin D and E can improve muscle mass and muscle strength in patients with muscular attenuation syndrome, and supplement whey protein. Vitamin D and E can improve quality of life in patients with muscular attenuation syndrome. Vitamin D and E can improve serum triglyceride, insulin-like growth factor-1 and interleukin-2 levels in patients with muscular attenuation syndrome.
【學(xué)位授予單位】：鄭州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R685

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