本文選題：術后認知功能障礙　切入點：手術　出處：《中南大學學報(醫(yī)學版)》2017年11期 　論文類型：期刊論文

【摘要】：術后認知功能障礙(postoperative cognitive dysfunction,POCD)是一種輕度的認知功能紊亂,是指術前無認知障礙的患者在麻醉手術后出現(xiàn)精神活動、人格、社交活動及認知能力的改變。記憶減退是認知功能障礙患者的核心癥狀及表現(xiàn),年齡是術后長期認知功能損害的主要危險因素。POCD的發(fā)生將延長患者的住院時間,降低患者的生存質(zhì)量,增加術后死亡率,給個人和社會造成嚴重負擔。如何有效地預防、干預POCD的發(fā)生發(fā)展,減少不良后果,是手術患者(尤其是老年患者)圍手術期亟需解決的問題。雖然POCD的病理生理機制仍然不明,但目前傾向于認為炎癥在POCD中扮演重要作用。無菌手術誘導外周炎癥反應,通過相關途徑傳入中樞,因個體差異,導致了不同嚴重程度的中樞炎癥反應,進而引起POCD。因此,針對POCD的防治方法也應著重圍繞減輕炎癥反應展開。
[Abstract]:Postoperative cognitive dysfunctional POCDD is a mild cognitive disorder, which refers to the mental activity and personality of patients without cognitive impairment before anesthesia. Memory impairment is the core symptom and manifestation of cognitive dysfunction. Age is the main risk factor of long-term cognitive impairment. POCD will prolong the hospitalization time of the patients. How to effectively prevent and intervene in the occurrence and development of POCD, and reduce the adverse consequences, reduce the quality of life of patients, increase the postoperative mortality, and cause a serious burden to individuals and society. Although the pathophysiological mechanism of POCD is still unknown, it tends to think that inflammation plays an important role in POCD. Because of the individual difference, the central inflammatory reaction of different severity is caused by the relevant pathway. Therefore, the prevention and treatment of POCD should focus on alleviating the inflammatory reaction.
【作者單位】： 中南大學湘雅三醫(yī)院麻醉科;
【基金】：國家自然科學基金(81371216)~~
【分類號】：R614
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本文編號：1640887