本文選題：骨質(zhì)疏松　切入點：椎體壓縮骨折　出處：《中國脊柱脊髓雜志》2017年07期 　論文類型：期刊論文

【摘要】：目的:應(yīng)用Meta分析評價經(jīng)皮椎體后凸成形術(shù)(PKP)治療骨質(zhì)疏松性椎體壓縮骨折(OVCF)的遠期并發(fā)癥,為臨床應(yīng)用提供依據(jù)。方法:計算機檢索CNKI、CBM、Pub Med、The Cochrane Library(2017年第2期)、Wiley Online Library、ELSEVIER Science Direct(SDOS)數(shù)據(jù)庫,檢索時間均是從建庫到2017年2月。收集PKP與保守治療OVCF的相關(guān)隨機對照試驗(RCT)文獻,經(jīng)X線、CT及MRI確定診斷為胸腰椎壓縮骨折;骨密度測量儀測量確定存在胸腰椎骨質(zhì)疏松(T≤-2.5);年齡≥50歲,病程6個月;術(shù)后結(jié)局指標至少包括以下指標中的一項:新發(fā)椎體骨折、鄰近節(jié)段椎體骨折、嚴重并發(fā)癥、視覺模擬評分。參考Cochrane系統(tǒng)評價手冊5.0.1提供的針對隨機對照試驗的評價標準對納入文獻質(zhì)量進行評價。結(jié)果:共納入5篇RCT研究,4篇為英文文獻,1篇為中文文獻,方法學質(zhì)量評價4篇文獻為4分及以上,1篇文獻為3分。PKP組共計417例,保守治療組共計458例。Meta分析結(jié)果顯示,PKP組治療后3~6個月視覺模擬評分(VAS)與保守治療組相比有統(tǒng)計學意義[MD=-0.36,95%CI(-0.65,-0.07),P=0.02];在新發(fā)椎體骨折、鄰近節(jié)段椎體再發(fā)骨折、嚴重并發(fā)癥三個方面PKP組與保守治療組無統(tǒng)計學差異。結(jié)論:應(yīng)用PKP治療OVCF可以降低患者疼痛VAS評分,并且不會提高新發(fā)椎體骨折、鄰近節(jié)段椎體再發(fā)骨折、嚴重并發(fā)癥的發(fā)生風險。
[Abstract]:Objective: to evaluate the long-term complications of percutaneous transluminal kyphoplasty (PKP) in the treatment of osteoporotic vertebral compression fractures (OVCFS) and to provide evidence for clinical application. Methods: the Cochrane Library database was searched by computer. The retrieval time was from the establishment of the database to February 2017. The literature on PKP and the randomized controlled trial of conservative treatment of OVCF were collected and diagnosed as thoracolumbar compression fractures by X-ray CT and MRI. The measurement of bone mineral density determined the existence of thoracolumbar vertebrae osteoporosis T 鈮，

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