本文選題：鈷鉻鉬合金　切入點：生物假體　出處：《中國組織工程研究》2017年15期 　論文類型：期刊論文

【摘要】：背景:在關(guān)節(jié)置換領(lǐng)域里,金屬合金材料始終處于主導(dǎo)地位,但這種材料的最大缺陷是彈性模量高,由此產(chǎn)生應(yīng)力遮擋,進(jìn)而引起骨吸收、骨萎縮甚至假體松動等一系列并發(fā)癥。碳纖維增強聚醚醚酮復(fù)合材料是各向異性材料,可以達(dá)到低彈高強,應(yīng)用于制備人工假體有許多優(yōu)勢。目的:探討碳纖維增強聚醚醚酮復(fù)合材料的血液相容性,并比較了碳纖維增強聚醚醚酮復(fù)合材料股骨頭假體和鈷鉻鉬合金股骨頭假體置換后的生物力學(xué)特性。方法:(1)以溶血實驗評價碳纖維增強聚醚醚酮復(fù)合材料的血液相容性;(2)收集8對新鮮成人尸體股骨標(biāo)本,隨機分為碳纖維增強聚醚醚酮假體組和鈷鉻鉬合金假體組進(jìn)行相應(yīng)假體置換,測量加載200,400,600,800,1 000 N負(fù)荷下假體與骨之間的微動量,并檢測假體置換后的抗扭轉(zhuǎn)強度。結(jié)果與結(jié)論:(1)以碳纖維增強聚醚醚酮復(fù)合材料的溶血率為3.23%5%,符合國家醫(yī)療器械生物學(xué)評價標(biāo)準(zhǔn);(2)2組假體遠(yuǎn)端微動均明顯小于近端(P0.05);不同負(fù)荷下鈷鉻鉬合金假體組遠(yuǎn)端、近端的微動量均顯著大于碳纖維增強聚醚醚酮假體組(P0.05);(3)碳纖維增強聚醚醚酮假體組不同負(fù)荷下的載荷-扭角均顯著小于鈷鉻鉬合金假體組(P0.05),抗扭剛度均顯著大于鈷鉻鉬合金假體組(P0.05);(4)結(jié)果說明碳纖維增強聚醚醚酮復(fù)合材料血液相容性較好,具有較好的穩(wěn)定性,可用于假體置換。
[Abstract]:Background: in the field of joint replacement, metal alloy materials are always in the dominant position, but the biggest defect of this material is the high modulus of elasticity, which results in stress occlusion, which leads to bone resorption. Carbon fiber reinforced polyether ether ketone composite is an anisotropic material that can achieve low elasticity and high strength. There are many advantages in the preparation of artificial prostheses. Objective: to study the blood compatibility of carbon fiber reinforced polyether ether ketone composites. The biomechanical properties of carbon fiber reinforced poly (ether ether ketone) composite femoral head prosthesis and cobalt-chromium-molybdenum alloy femoral head prosthesis were compared. Methods Hemolysis experiment was used to evaluate the blood of carbon fiber reinforced polyether ether ketone composite. Eight pairs of fresh adult cadaveric femur specimens were collected. Carbon fiber reinforced polyether ether ketone prosthesis group and cobalt chromium-molybdenum alloy prosthesis group were randomly divided into two groups. Results and conclusion the hemolysis rate of carbon fiber reinforced polyether ether ketone composite material is 3.235, which conforms to the national biological evaluation standard of medical devices. The distal fretting of the two groups is obviously smaller than that of the near. P0.05N; distal end of cobalt-chromium-molybdenum alloy prosthesis group under different loads, The micromomentum at the proximal end was significantly higher than that in the carbon fiber reinforced polyether ether ketone prosthesis group (P 0.05). The load-torsion angle of the carbon fiber reinforced polyether ether ketone prosthesis group was significantly lower than that of the cobalt chromium molybdenum alloy prosthesis group (P 0.05), and the torsional stiffness was significantly higher than that of the Co Cr Mo alloy prosthesis group. The results showed that carbon fiber reinforced polyether ether ketone composite had better blood compatibility. It has good stability and can be used in prosthesis replacement.
【作者單位】： 海南醫(yī)學(xué)院第一附屬醫(yī)院;
【基金】：海南省自然科學(xué)基金資助項目(814357)~~
【分類號】：R318.08;R687.4

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