發(fā)布時間：2018-03-09 16:11

  本文選題：補腎散寒通絡(luò)湯　切入點：艾灸　出處：《中國藥房》2017年26期 　論文類型：期刊論文

【摘要】：目的:觀察補腎散寒通絡(luò)湯聯(lián)合艾灸及塞來昔布治療膝骨關(guān)節(jié)炎(KOA)的臨床療效及安全性。方法:選取2014年5月-2015年12月在重慶康華醫(yī)院就診的KOA患者70例,按照就診單雙號順序分為對照組和觀察組,各35例。對照組患者給予塞來昔布膠囊0.2 g,qd;觀察組患者在對照組基礎(chǔ)上加用補腎散寒通絡(luò)湯(每日1劑,水煎取汁300 mL,分早、中、晚3次服用)及艾灸治療。兩組患者均以4周為1個療程,連續(xù)治療2個療程。比較兩組患者的臨床療效,治療前后的中醫(yī)證候積分、視覺模擬評分法(VAS)評分、西安大略和麥克馬斯特大學(xué)量表(WOMAC)評分、實驗室檢查指標(biāo)、關(guān)節(jié)情況,以及不良反應(yīng)發(fā)生情況。結(jié)果:觀察組患者的總有效率(85.71%)顯著高于對照組(68.57%),差異有統(tǒng)計學(xué)意義(P0.05)。治療前,兩組患者的上述指標(biāo)比較,差異均無統(tǒng)計學(xué)意義(P0.05)。治療后,兩組患者的中醫(yī)證候積分、VAS評分、WOMAC評分、紅細胞沉降率、C反應(yīng)蛋白水平和膝關(guān)節(jié)腫脹積分均較治療前顯著降低,且觀察組各指標(biāo)水平顯著低于對照組,差異均有統(tǒng)計學(xué)意義(P0.05);兩組患者治療前后骨摩擦音關(guān)節(jié)個數(shù)比較,差異均無統(tǒng)計學(xué)意義(P0.05)。兩組患者不良反應(yīng)發(fā)生率比較(5.71%vs.2.86%),差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:補腎散寒通絡(luò)湯聯(lián)合艾灸及塞來昔布能改善KOA患者臨床癥狀,緩解關(guān)節(jié)疼痛,減輕關(guān)節(jié)炎癥和腫脹,且用藥較安全。
[Abstract]:Objective: To observe the effect of Bushen Tongluo decoction combined with cold moxibustion and celecoxib in the treatment of knee osteoarthritis (KOA) clinical efficacy and safety. Methods: May 2014 -2015 year in December 70 cases of Chongqing Hong Wah hospital KOA patients according to clinical single, randomly divided into control group and observation group, 35 cases in each 0.2. The control group were treated with Celecoxib Capsules g, QD; patients in the observation group in the control group based on the use of Bushen Tongluo Decoction (cold dispelling agent 1, daily Decoction 300 mL, early, late, 3 doses) and moxibustion treatment. Two patients were in 4 weeks as 1 course. Continuous 2 courses of treatment. The clinical efficacy of two groups were compared before and after treatment, TCM syndrome score, visual analogue scale (VAS) score, Xi'an and Ontario McMaster University scale (WOMAC) score, laboratory examination indexes, joint, and adverse reactions. Results: the patients in the observation group The total effective rate (85.71%) was significantly higher than the control group (68.57%), the difference was statistically significant (P0.05). Before the treatment, comparing the index of the two groups, there were no significant differences (P0.05). After treatment, the TCM syndromes, two groups of patients with VAS score, WOMAC score, red blood cell sedimentation rate, C reactive protein level and the knee joint swelling score were significantly lower than those before treatment, and the observation group each index level was significantly lower than the control group, the differences were statistically significant (P0.05); bone fricative joint number of two groups of patients before and after treatment, there were no significant differences (P0.05) occurred in two patients. The adverse reaction rate (5.71%vs.2.86%), the difference was not statistically significant (P0.05). Conclusion: Bushen Tongluo decoction combined with cold moxibustion and celecoxib can improve the clinical symptoms of KOA patients, relieve joint pain, reduce joint inflammation and swelling, and the drug is safe.

【作者單位】： 重慶醫(yī)科大學(xué)中醫(yī)藥學(xué)院;西南醫(yī)科大學(xué)臨床醫(yī)學(xué)院;重慶康華醫(yī)院中醫(yī)科;
【基金】：國家自然科學(xué)基金(青年科學(xué)基金)資助項目(No.81674002)
【分類號】：R684.3
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本文編號：1589263