發(fā)布時間：2018-03-05 00:03

  本文選題：組織工程支架　切入點：微孔結(jié)構(gòu)　出處：《新疆大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：組織工程骨支架的結(jié)構(gòu)決定著仿生人工骨的成骨性能,因此支架不僅需要三維微孔結(jié)構(gòu)且需要有足夠的強(qiáng)度。針對支架需要足夠的孔隙率和足夠的強(qiáng)度的需求,本文進(jìn)行了研究。利用有限元分析軟件,對人工骨支架的微孔結(jié)構(gòu)對支架應(yīng)力、應(yīng)變和變形的影響,進(jìn)行了數(shù)值模擬研究。同時利用力學(xué)壓縮實驗對人工骨支架結(jié)構(gòu)的力學(xué)性能進(jìn)行驗證分析。對單一材料生物陶瓷β-磷酸三鈣(β-TCP)人工骨支架內(nèi)部的微孔結(jié)構(gòu)進(jìn)行優(yōu)化設(shè)計。利用ANYSY軟件建立支架微孔結(jié)構(gòu)的三維模型,三維模型賦予其邊界條件、載荷條件、材料參數(shù),進(jìn)行網(wǎng)格劃分。然后定義變化參數(shù)及參數(shù)范圍,對其進(jìn)行優(yōu)化分析,計算得到模型的最大等效應(yīng)力及最大總變形與孔隙率的關(guān)系,并分析比較不同孔徑、孔間距結(jié)構(gòu)對支架最大等效應(yīng)力、最大總變形、內(nèi)部應(yīng)變的影響。支架孔隙率和最佳應(yīng)變比越大,最大等效應(yīng)力、最大總變形越小,支架生物性能和力學(xué)性能越好。分析得到了微孔各個參數(shù)對支架孔隙率、最大等效應(yīng)力、最大總變形以及內(nèi)部應(yīng)變的影響規(guī)律,這些結(jié)果為支架的結(jié)構(gòu)設(shè)計和優(yōu)化提供了有意義的參考價值。為復(fù)合結(jié)構(gòu)中鈦合金TC4支架結(jié)構(gòu)的分布作前期研究,對鈦合金支架進(jìn)行了優(yōu)化設(shè)計。建立鈦合金支架各個方向不同層數(shù)和不同直徑的鈦合金支架模型,對其進(jìn)行有限元分析,提取支架的最大等效應(yīng)力和最大總變形。同時利用激光選區(qū)熔化技術(shù)(Selective Laser Melting,SLM)制備鈦合金支架結(jié)構(gòu),利用力學(xué)實驗對模擬仿真的結(jié)果進(jìn)行驗證。結(jié)果顯示增加Z軸方向鈦合金直徑和X軸方向鈦合金層數(shù)時,更有利于提高支架的力學(xué)性能。對生物陶瓷-鈦合金復(fù)合結(jié)構(gòu)人工骨支架的內(nèi)部結(jié)構(gòu)的進(jìn)行了設(shè)計,并對復(fù)合結(jié)構(gòu)中鈦合金支架結(jié)構(gòu)的分布和直徑對支架力學(xué)性能的影響進(jìn)行了研究與分析。利用ANYSY軟件建立鈦合金的分布和直徑的不同的復(fù)合支架結(jié)構(gòu)有限元模型,計算支架最大等效應(yīng)力、最大總變形。本章計算結(jié)果顯示復(fù)合結(jié)構(gòu)中鈦合金支架結(jié)構(gòu)的受力面積越大,支架最大等效應(yīng)力、最大總變形越小,支架生物性能和力學(xué)性能越好。分析得到了鈦合金支架結(jié)構(gòu)各個參數(shù)對支架最大等效應(yīng)力、最大總變形的影響規(guī)律,這些結(jié)果為支架的結(jié)構(gòu)設(shè)計和優(yōu)化提供了有意義的參考價值。
[Abstract]:The structure of tissue engineered bone scaffolds determines the osteogenic properties of biomimetic artificial bones, so the scaffolds need not only three-dimensional microporous structures but also sufficient strength. In this paper, the effect of micropore structure on stress, strain and deformation of artificial bone scaffold was studied by using finite element analysis software. At the same time, the mechanical properties of the artificial bone scaffold were verified and analyzed by mechanical compression experiment. The micropore structure of the single material bioceramics 尾 -TCP-based artificial bone scaffold was optimized. Using ANYSY software to build three-dimensional model of scaffold micropore structure, The 3D model gives it boundary conditions, load conditions, material parameters, meshes, and then defines the variation parameters and parameter ranges, and analyzes them optimally. The relationship between the maximum equivalent stress and the maximum total deformation of the model and the porosity is obtained, and the maximum equivalent stress and the maximum total deformation of the support with different pore sizes and pore spacing structures are analyzed and compared. The larger the porosity and the optimum strain ratio, the greater the maximum equivalent stress, the smaller the maximum total deformation, the better the biomechanical and mechanical properties of the scaffold. The maximum total deformation and the influence of internal strain provide a significant reference value for the structural design and optimization of the support, and provide a preliminary study for the distribution of titanium alloy TC4 scaffold structures in composite structures. The optimal design of titanium alloy bracket was carried out. The model of titanium alloy stent with different layers and diameters in different directions was established, and the finite element analysis was carried out. The maximum equivalent stress and total deformation of the scaffold were extracted. At the same time, the titanium alloy scaffold structure was prepared by laser selective Laser melting technique. The simulation results are verified by mechanical experiments. The results show that when the diameter of Z axis titanium alloy and the number of X axis titanium alloy layers are increased, The internal structure of the scaffold with bioceramic-titanium alloy composite structure was designed. The influence of the distribution and diameter of titanium alloy bracket structure on the mechanical properties of the composite structure was studied and analyzed. The finite element model of titanium alloy composite scaffold structure with different distributions and diameters was established by using ANYSY software. In this chapter, the results show that the larger the bearing area of titanium alloy bracket, the smaller the maximum equivalent stress and the smaller the total deformation. The better the biomechanical and mechanical properties of the scaffolds are, the influence of the parameters of the titanium alloy scaffolds on the maximum equivalent stress and the maximum total deformation of the scaffolds are obtained. These results provide a valuable reference for the structural design and optimization of the scaffold.
【學(xué)位授予單位】：新疆大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R318.17;R687

【參考文獻(xiàn)】

相關(guān)期刊論文 前4條

1 徐尚龍,李滌塵,盧秉恒;基于細(xì)胞沉積的人工骨微管設(shè)計及三維流場分析[J];機(jī)械工程學(xué)報;2005年04期

2 徐尚龍;李滌塵;盧秉恒;;人工骨體外灌注中微管道內(nèi)細(xì)胞及細(xì)胞懸液兩相流數(shù)值研究[J];機(jī)械工程學(xué)報;2006年03期

3 吳任東;楊輝;張磊;胡川;;組織工程支架快速成形技術(shù)研究現(xiàn)狀[J];機(jī)械工程學(xué)報;2011年05期

4 尚希福;湯亭亭;戴\戎;;磷酸三鈣骨水泥骨長入的實驗[J];中國組織工程研究與臨床康復(fù);2007年18期

相關(guān)碩士學(xué)位論文 前1條

1 陳若夢;陶瓷—金屬復(fù)合人工骨仿生結(jié)構(gòu)設(shè)計基礎(chǔ)研究[D];新疆大學(xué);2013年

，

本文編號：1567864