骨炎與慢性鼻—鼻竇炎關系的薈萃分析
本文關鍵詞: 骨炎 慢性鼻-鼻竇炎 LMS LKS 鼻息肉 修正手術 薈萃分析 出處:《華中科技大學》2015年碩士論文 論文類型:學位論文
【摘要】:[目的]骨炎被認為是影響慢性鼻-鼻竇炎(chronic rhinosinusitis,CRS)發(fā)生、發(fā)展及預后的一項重要因素,但以往的研究在骨炎是否與CRS疾病的嚴重程度、與CRS患者鼻息肉的患病率、以及CRS患者經歷反復手術等方面直接相關仍有爭論,本研究擬用薈萃分析方法來對以上問題進行詳盡探討。[方法]兩名評價人員按事先制定的檢索策略分別檢索Pub Med、Web of Science、Embase數(shù)據庫,嚴格執(zhí)行納入和排除標準篩選骨炎和CRS相關的文獻。應用Rev Man5.3軟件對所收集數(shù)據進行分析。[結果]本薈萃分析共納入9篇文獻,1097例CRS患者。薈萃分析結果顯示骨炎組的鼻竇黏膜評分(Lund-Mackay score,LMS)較無骨炎組高:標準化均數(shù)差(standard mean difference,SMD)為1.13,95%置信區(qū)間(confidence interval,CI)為0.72-1.54,P0.01。骨炎組的鼻內鏡評分(Lund-Kennedy score,LKS)較無骨炎組高:SMD為1.00,95%CI為0.54-1.46,P0.01。骨炎組的鼻息肉患病率較無骨炎組高:比值比(Odds ratio,OR)為3.14,95%CI為1.67-5.90,P0.01。修正手術組的骨炎患病率較初次手術組高:OR為4.43,95%CI為3.05-6.43,P0.01。[結論]本薈萃分析結果顯示,骨炎和CRS的嚴重程度呈正相關(骨炎組的LMS和LKS均高于無骨炎組),CRS患者中的鼻息肉患病率與骨炎患病率呈正相關,經歷修正手術的CRS患者相對于經歷初次手術的CRS患者骨炎患病率明顯提高,這些差異均具有統(tǒng)計學上的意義。
[Abstract]:[objective] Osteositis is considered to be an important factor affecting the occurrence, development and prognosis of chronic rhinosinusitis (CRS), but previous studies on whether osteositis is associated with the severity of CRS disease and the prevalence of nasal polyps in CRS patients, And the direct correlation between CRS patients and repeated surgery is still controversial. In this study, the meta-analysis method was used to explore the above problems in detail. [methods] two evaluators searched the Pub Meden web of Science Embase database according to the search strategy made in advance. The data collected were analyzed by Rev Man5.3 software. [results] A total of 1 097 CRS patients were included in this meta-analysis. Meta-analysis showed bone. The nasal mucosa score in the inflammation group was higher than that in the non-osteositis group: the standard mean difference was 1.1395% confidence interval) (0.72-1.54% confidence interval). The nasal endoscopy score of the osteositis group Lund-Kennedy scorebook LKSs was higher than that of the non-osteositis group. The nasal morbidity rate of the osteositis group was 1.00 ~ 1.46% P0.00.The nasal prevalence rate of the osteositis group was higher than that of the non-osteositis group. The nasal morbidity rate of the osteositis group was higher than that of the non-osteositis group (1.00 ~ 95CI = 1.004-1.46). The nasal morbidity rate of the osteositis group was higher than that of the non-osteositis group. The incidence of osteositis in the modified operation group was higher than that in the first operation group (3.05-6.43 P0.01.Conclusion the meta-analysis shows that the incidence of osteositis in the modified operation group is higher than that in the first operation group. [conclusion] the meta-analysis shows that the incidence of osteositis in the modified operation group is higher than that in the first operation group. [conclusion] the results of meta-analysis show that the incidence of osteositis in the modified operation group is higher than that in the first operation group. There was a positive correlation between the severity of Osteitis and CRS (LMS and LKS in Osteositis group were higher than those in Osteositis group and Osteositis group. The incidence of osteositis in CRS patients undergoing correction surgery was significantly higher than that in CRS patients undergoing the first operation, and these differences were statistically significant.
【學位授予單位】:華中科技大學
【學位級別】:碩士
【學位授予年份】:2015
【分類號】:R765;R681.2
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