本文關鍵詞： 膝關節(jié) 骨性關節(jié)炎 流行病學　出處：《山東中醫(yī)藥大學》2015年碩士論文　論文類型：學位論文

【摘要】：目的:通過調(diào)查研究411例膝關節(jié)骨性關節(jié)炎患者的臨床資料,對其致病因素、發(fā)病特點、變化規(guī)律等資料進行系統(tǒng)統(tǒng)計分析,了解膝關節(jié)骨性關節(jié)炎的流行病學特點,探究膝關節(jié)骨性關節(jié)炎的發(fā)生發(fā)展規(guī)律,指導對膝關節(jié)骨性關節(jié)炎的臨床診療工作。方法:自2013年01月01日至2014年12月31日,山東中醫(yī)藥大學附屬醫(yī)院關節(jié)骨科收治膝關節(jié)骨性關節(jié)炎患者總計472例,其中符合本課題納入標準的411例,采用病例資料統(tǒng)計配合電話回訪的方式統(tǒng)計所有這些患者的臨床資料,包括性別、職業(yè)、出入院時間、入院年齡、發(fā)病年齡、體重指數(shù)、患膝內(nèi)外翻畸形有無等相關數(shù)據(jù)進行統(tǒng)計整理,并應用統(tǒng)計學方法進行系統(tǒng)歸納分析,主要包括獨立樣本t檢驗和單樣本t檢驗,以P值等于0.05作為判斷統(tǒng)計結果具有顯著性差異的標準。成果:411例患者均獲得完整的臨床資料,其中男性患者87人,占27.97%,女性患者324人,占78.83%,男女比例1:3.72,平均年齡65.2±8.1歲,平均發(fā)病年齡55.6±10.8歲。對其進行的獨立樣本t檢驗表明,男女患者的年齡分布有顯著性差異(P0.05),女性患者的發(fā)病年齡要明顯早于男性患者。在體重指數(shù)方面的統(tǒng)計結果分析顯示,與體重指數(shù)=23這一超重臨界值相比,411例患者有明顯的超重傾向(P0.05),然而,男女患者在體重指數(shù)方面的對比并無明顯不同。絕大多數(shù)患者存在不同程度的膝關節(jié)內(nèi)外翻畸形,其中以內(nèi)翻畸形最為常見,外翻畸形少見,也有極少部分患者并沒有膝關節(jié)內(nèi)外翻畸形。對于患者發(fā)病部位的統(tǒng)計分析結果顯示,雙膝發(fā)病的患者207人,占患者總?cè)藬?shù)的50.36%,單膝發(fā)病的患者204人,占患者總?cè)藬?shù)的49.64%,其中左右膝發(fā)病率基本持平,其差異無統(tǒng)計學意義�；颊叩穆殬I(yè)分布及城鄉(xiāng)分布情況經(jīng)統(tǒng)計學分析無明顯統(tǒng)計學差異。相比較與2012年同一時期,2013年收治的膝關節(jié)骨性關節(jié)炎患者的數(shù)量所占比例有明顯增高。結論:年齡、性別、體重指數(shù)對膝關節(jié)骨性關節(jié)炎的發(fā)病有一定程度的影響。膝關節(jié)骨性關節(jié)炎一般好發(fā)于40~70歲的患者,在50~60歲的人群中,膝關節(jié)骨性關節(jié)炎的發(fā)病率最高;肥胖是膝關節(jié)骨性關節(jié)炎發(fā)病的誘導因素之一,體重指數(shù)較高的人有更高的幾率患膝關節(jié)骨性關節(jié)炎。膝關節(jié)骨性關節(jié)炎可以引起患者的膝關節(jié)內(nèi)外翻畸形,一般來說,膝關節(jié)骨性關節(jié)炎更容易引起膝關節(jié)內(nèi)翻畸形,較少導致膝關節(jié)外翻畸形。職業(yè)及城鄉(xiāng)分布與膝關節(jié)骨性關節(jié)炎的發(fā)病并沒有顯著關系,城鄉(xiāng)居民的膝關節(jié)骨性關節(jié)炎發(fā)病幾率基本相同。隨著時間的發(fā)展,膝關節(jié)骨性關節(jié)炎的發(fā)病率有增多的趨勢,應當引起醫(yī)務人員和好發(fā)人群更多的關注。
[Abstract]:Objective: to investigate the clinical data of 411 patients with knee osteoarthritis, and to analyze systematically the pathogenic factors, the characteristics of the disease and the changes of the disease, so as to understand the epidemiological characteristics of the osteoarthritis of the knee. To explore the occurrence and development of knee osteoarthritis and to guide the clinical diagnosis and treatment of knee osteoarthritis. Methods: from January 1st 2013 to December 31st 2014, A total of 472 patients with knee osteoarthritis were admitted to the Department of Orthopaedics of the affiliated Hospital of Shandong University of traditional Chinese Medicine. The clinical data of all these patients, including sex, occupation, time out of hospital, admission age, age of onset, body mass index, were analyzed by using case statistics and telephone return visits. The related data such as the existence or absence of varus genicularis were statistically analyzed, and the statistical methods were used to analyze them systematically, including independent t-test and single-sample t-test. Results the clinical data of 411 patients were obtained, including 87 male patients (27.97%) and 324 female patients (78.833%). The ratio of male to female was 1: 3.72, with an average age of 65.2 鹵8.1 years. The average age of onset was 55.6 鹵10.8 years old. T test of independent sample showed that there was a significant difference in age distribution between male and female patients (P 0.05). The age of onset in female patients was significantly earlier than that in male patients. The statistical results of body mass index showed that the age distribution of female patients was significantly earlier than that of male patients. Compared with the critical value of body mass index (BMI) of 23, 411 patients had significant tendency to be overweight, however, there was no significant difference in body mass index between male and female patients. Most of the patients had different degrees of knee joint varus deformity. Varus deformities are the most common, valgus deformities are rare, and few patients do not have varus deformities of the knee. Accounting for 50.36% of the total number of patients, 204 patients with single knee disease, accounting for 49.64% of the total number of patients, the incidence of left and right knees was basically equal. There was no statistical difference between them. There was no statistical difference in the occupational distribution and urban and rural distribution of the patients. Compared with the same period on 2012, the proportion of patients with osteoarthritis of knee joint treated in 2013 was higher than that in the same period on 2012. There was a marked increase in the number of cases. Conclusion: age, Sex and body mass index (BMI) had a certain influence on the incidence of knee osteoarthritis. The incidence of knee osteoarthritis was the highest in the population of 50 to 60 years old. Obesity is one of the leading factors in the development of knee osteoarthritis, and people with higher BMI are more likely to develop osteoarthritis of the knee. Knee osteoarthritis is more likely to cause varus deformity of the knee joint and less to the valgus of knee joint. There is no significant relationship between occupation and urban and rural distribution of knee joint osteoarthritis. The incidence rate of knee osteoarthritis in urban and rural residents is basically the same. With the development of time, the incidence of knee osteoarthritis has an increasing trend, which should be paid more attention to by medical staff and people who are prone to knee joint osteoarthritis.
【學位授予單位】：山東中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R684.3

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