本文關(guān)鍵詞： 氟比洛芬酯 骨科手術(shù) 鎮(zhèn)痛 C反應(yīng)蛋白 前列腺素E　出處：《中國臨床藥理學(xué)雜志》2016年02期 　論文類型：期刊論文

【摘要】：目的觀察氟比洛芬酯注射液對(duì)骨科手術(shù)超前鎮(zhèn)痛及術(shù)后鎮(zhèn)痛的臨床療效。方法 78例骨科手術(shù)治療的患者隨機(jī)分為試驗(yàn)組39例和對(duì)照組39例。對(duì)照組患者麻醉前15 min靜脈注射帕瑞昔布鈉20 mg(10 m L);使用丙泊酚1~2mg·kg~(-1)誘導(dǎo)麻醉,術(shù)中使用異氟烷維持麻醉;術(shù)后將帕瑞昔布鈉60 mg加0.9%氯化鈉配至100 m L,靜脈滴注。試驗(yàn)組患者麻醉前15 min靜脈注射氟比洛芬酯50 mg;使用丙泊酚1~2 mg·kg~(-1)誘導(dǎo)麻醉,術(shù)中使用異氟烷維持麻醉;術(shù)后將氟比洛芬酯50 mg加0.9%氯化鈉配至100 m L,靜脈滴注。記錄患者術(shù)前或術(shù)后的平均動(dòng)脈壓、心率、視覺模擬評(píng)分(VAS)、Ramsay鎮(zhèn)靜評(píng)分(RSS)以及前列腺素E2(PGE2)、血清C反應(yīng)蛋白(CRP)含量;同時(shí)統(tǒng)計(jì)2組的不良反應(yīng)發(fā)生率。結(jié)果除術(shù)后即刻的VAS評(píng)分試驗(yàn)組低于對(duì)照組外(P0.05),2組患者的平均動(dòng)脈壓和心率、VAS、RSS差異均無統(tǒng)計(jì)學(xué)意義。試驗(yàn)組術(shù)后24 h的血清CRP含量為(16.77±5.52)mg·L~(-1),顯著低于對(duì)照組的(20.68±7.76)mg·L~(-1)(P0.05);試驗(yàn)組術(shù)后24 h的血清PGE2含量與對(duì)照組差異無統(tǒng)計(jì)學(xué)意義(135.1 vs 141.6 pg·mL~(-1),P0.05)。試驗(yàn)組的不良反應(yīng)發(fā)生率顯著低于對(duì)照組(7.7%vs 20.5%,P0.05)。結(jié)論氟比洛芬酯注射液用于骨科手術(shù)患者鎮(zhèn)痛效果較好,減輕患者的應(yīng)激反應(yīng),減少不良反應(yīng)發(fā)生率。
[Abstract]:Objective to observe the clinical effect of flurbiprofen injection on preemptive analgesia and postoperative analgesia in orthopedic surgery. Methods 78 patients undergoing orthopedic surgery were randomly divided into trial group (n = 39) and control group (n = 39). Anesthesia was induced by intravenous injection of paroxib sodium for 15 min (20 mg(10 mL) and propofol (2 mg 路kg ~ (-1)). Intraoperative anesthesia was maintained with isoflurane, 60 mg paroxib sodium plus 0.9% sodium chloride was injected intravenously to 100ml after operation. In the trial group, 50 mg flurbiprofen ester was injected intravenously 15 min before anesthesia, and 2 mg 路kg -1 propofol was used to induce anesthesia. Intraoperative maintenance anesthesia was performed with isoflurane, 50 mg flurbiprofen ester plus 0.9% sodium chloride was injected intravenously after operation. Mean arterial pressure and heart rate were recorded before and after operation. Visual analogue score (VAS) and Ramsay sedative score (RSSs) and prostaglandin E _ 2 (PGE _ 2), serum C-reactive protein (CRP) levels; Results there was no significant difference in the mean arterial pressure and heart rate of VAS between the two groups except that in the control group (P 0.05). The serum CRP in the trial group 24 hours after operation was not significantly different from that in the control group. The level of serum PGE2 in the trial group was significantly lower than that in the control group (16.77 鹵5.52 mg 路L ~ (-1)), which was significantly lower than that in the control group (20.68 鹵7.76) mg 路L ~ (-1) (P ~ (0.05)), but there was no significant difference between the two groups at 24 hours after operation, and there was no significant difference between the experimental group and the control group (135.1 vs 141.6 PG 路mL ~ (-1) P 0.055.The incidence of adverse reactions in the trial group was significantly lower than that in the control group (7.7g / L vs 20.5p 0.05). Conclusion flurbiprofen ester is injected with flurbiprofen ester. The analgesic effect of injecting liquid in orthopedic surgery patients is better. Reduce the stress reaction and the incidence of adverse reactions.
【作者單位】： 瑞安市人民醫(yī)院護(hù)理部;
【分類號(hào)】：R614

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