本文關(guān)鍵詞： 逍遙散 腦外傷后綜合征 軀體健康 精神健康　出處：《廣州中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:本課題通過(guò)在腦外傷后綜合征(post traumatic brain syndrome,PTBS)患者中分別應(yīng)用逍遙散聯(lián)合常規(guī)西藥治療、單純常規(guī)西藥治療兩種方案,觀察比較兩種治療方法對(duì)PTBS患者臨床癥狀、軀體健康及精神健康的改善情況來(lái)研究逍遙散治療PTBS的臨床療效。方法:在本次臨床試驗(yàn)中共有60例PTBS患者既符合納入標(biāo)準(zhǔn)又符合排除標(biāo)準(zhǔn),將這60例患者隨機(jī)地分為試驗(yàn)組和對(duì)照組,對(duì)照組30人,采取常規(guī)西藥治療,試驗(yàn)組30人,采取常規(guī)西藥聯(lián)合逍遙散。在患者治療前后分別用Rivermead腦外傷后綜合征癥狀問(wèn)卷量表、健康狀況調(diào)查問(wèn)卷 SF-36(The Short Form-36Health Survey,SF-36)量表評(píng)估患者的臨床癥狀及生活質(zhì)量,圍繞生活質(zhì)量的軀體健康和精神健康兩方面將該量表分為8個(gè)分量表進(jìn)行統(tǒng)計(jì)分析。整個(gè)治療周期為6周,通過(guò)比較兩組患者的治療前后Rivermead腦外傷后綜合征癥狀問(wèn)卷量表評(píng)分和SF-36評(píng)分來(lái)評(píng)價(jià)逍遙散在腦外傷綜合征治療中的作用。將所搜集的臨床數(shù)據(jù)運(yùn)用SPSS 20.0進(jìn)行統(tǒng)計(jì)分析,顯著性水平取α =0.05。結(jié)果:1.治療6周后,根據(jù)Rivermead腦外傷后綜合征癥狀問(wèn)卷量表評(píng)分結(jié)果,兩組患者癥狀評(píng)分等級(jí)經(jīng)秩和檢驗(yàn)(Mann-Whitney U檢驗(yàn))得P=0.0070.05,說(shuō)明兩組患者治療后癥狀評(píng)分等級(jí)有統(tǒng)計(jì)學(xué)差異。有效率評(píng)價(jià)方面,試驗(yàn)組患者顯效9例,有效18例,無(wú)效3例,總有效率90%;對(duì)照組患者顯效2例,有效19例,無(wú)效9例,總有效率70%,兩組總有效率差異經(jīng)秩和檢驗(yàn)(Mann-Whitney U檢驗(yàn))得P=0.0070.05,說(shuō)明兩組的總有效率差異有統(tǒng)計(jì)學(xué)意義。2.治療6周后,根據(jù)健康狀況調(diào)查問(wèn)卷SF-36量表評(píng)分結(jié)果,試驗(yàn)組和對(duì)照組在軀體健康方面(PCS)經(jīng)獨(dú)立樣本T檢驗(yàn)得P=0.6620.05,差異無(wú)統(tǒng)計(jì)學(xué)意義;軀體健康所包含的分量表?xiàng)l目經(jīng)秩和檢驗(yàn)(Mann-Whitney U檢驗(yàn))得生理機(jī)能P=0.986㧐0.05,生理職能 P=0.4130.05,軀體疼痛 P=0.8940.05,總體健康 P=0.4260.05,以上四方面差異皆無(wú)統(tǒng)計(jì)學(xué)意義;相反,在精神健康(MCS)經(jīng)獨(dú)立樣本T檢驗(yàn)P=0.0010.05,差異有統(tǒng)計(jì)學(xué)意義;精神健康所包含的分量表?xiàng)l目生命活力經(jīng)獨(dú)立樣本T驗(yàn)P=0.0440.05,精神健康所包含的其它分量表?xiàng)l目經(jīng)秩和檢驗(yàn)(Mann-Whitney U檢驗(yàn))得如下結(jié)果,社交功能P=0.0440.05,情感職能P=0.010.05,心理健康P=0.0340.05,以上四方面差異皆有統(tǒng)計(jì)學(xué)意義。結(jié)論:1.逍遙散在一定程度上可以緩解PTBS患者臨床癥狀,和單純西藥治療相比,聯(lián)合應(yīng)用逍遙散有增強(qiáng)臨床治療效果的作用。2.逍遙散有改善PTBS患者總體健康狀況的作用,尤其表現(xiàn)在對(duì)精神心理健康方面的改善作用。3.PTBS患者精神心理健康方面的改善對(duì)臨床癥狀的改善有一定的作用,臨床中應(yīng)重視對(duì)PTBS患者精神健康的治療。
[Abstract]:Objective: to observe and compare the clinical symptoms of patients with post traumatic brain syndrome (PTBS) by using Xiaoyao Powder combined with routine western medicine and simple routine western medicine respectively. To study the clinical efficacy of Xiaoyao Powder in the treatment of PTBS methods: in this clinical trial, 60 patients with PTBS met both inclusion and exclusion criteria. The 60 patients were randomly divided into the experimental group and the control group. 30 patients in the control group were treated with conventional western medicine, and 30 patients in the experimental group were treated with routine western medicine combined with Xiaoyao Powder. The patients were treated with Rivermead's symptom questionnaire before and after treatment. The SF-36(The Short Form-36Health Survey (SF-36) scale was used to evaluate the clinical symptoms and quality of life (QOL) of the patients. The scale was divided into 8 subscales in terms of physical and mental health of QOL. The whole treatment period was 6 weeks. The effects of Xiaoyao Powder on the treatment of brain trauma syndrome were evaluated by comparing the scores of Rivermead and SF-36 before and after treatment. The collected clinical data were analyzed by SPSS 20.0. Results: 1. After 6 weeks of treatment, according to the scale of Rivermead posttraumatic syndrome questionnaire, The symptom score of the two groups was obtained by rank sum test (Mann-Whitney U test), indicating that there was statistical difference between the two groups after treatment. In the evaluation of effective rate, there were 9 cases of remarkable effect, 18 cases of effective effect and 3 cases of ineffectiveness in the trial group. The total effective rate was 90%; in the control group, there were 2 cases of remarkable effect, 19 cases of effective effect, 9 cases of ineffective, total effective rate of 70%, the difference of total effective rate of two groups was obtained by rank sum test (Mann-Whitney U test), indicating that the total effective rate of the two groups was significantly different after 6 weeks of treatment. According to the scores of SF-36 scale in the health status questionnaire, there was no significant difference between the test group and the control group in terms of physical health by independent sample T test (P < 0. 6620.05). The component table items contained in physical health were tested by rank sum test (Mann-Whitney U test). There was no significant difference in the above four aspects among the four aspects: physiological function (P < 0. 4130.05), somatic pain (P = 0. 8940.05), general health (P = 0. 4260.05), mental health (P = 0. 0010.05) and mental health (P = 0. 0010.05). The component table items contained in mental health were tested by independent sample T (P = 0.0440.05), and other subscale items included in mental health were tested by rank sum test (Mann-Whitney U test). Social function, affective function and mental health were all significantly different. Conclusion: Xiaoyao San can alleviate the clinical symptoms of patients with PTBS to a certain extent, compared with western medicine alone. The combined application of Xiaoyao Powder has the effect of enhancing the clinical therapeutic effect. 2. Xiaoyao Powder has the effect of improving the overall health status of patients with PTBS. Especially in the improvement of mental and mental health. 3. The improvement of mental and mental health has certain effect on the improvement of clinical symptoms. The treatment of mental health of patients with PTBS should be paid attention to in clinic.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R651.15

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 秦得營(yíng);;腦震蕩后綜合征的發(fā)生率、發(fā)病機(jī)制及相關(guān)影響因素的研究[J];臨床醫(yī)藥文獻(xiàn)電子雜志;2016年05期

2 韓毅;劉涌;張廣宇;杜立建;;腦外傷后血流變化的相關(guān)因素[J];現(xiàn)代中西醫(yī)結(jié)合雜志;2015年34期

3 江濤;鄢澤然;疏欣揚(yáng);劉金民;;腦外傷后綜合征的中醫(yī)證候?qū)W研究[J];時(shí)珍國(guó)醫(yī)國(guó)藥;2014年05期

4 張立新;;補(bǔ)陽(yáng)還五湯治療腦外傷后綜合征35例[J];實(shí)用中醫(yī)藥雜志;2014年04期

5 臧旭峰;蘇憲;王建飛;李強(qiáng);劉俊茹;耿韶輝;張志紅;;參麥注射液治療顱腦損傷后綜合征[J];河北醫(yī)藥;2012年15期

6 江濤;鄢澤然;疏欣揚(yáng);劉金民;;腦外傷后綜合征的中醫(yī)治療探討[J];實(shí)用中醫(yī)內(nèi)科雜志;2012年06期

7 李偉;;川芎嗪注射液對(duì)腦外傷后遺癥的治療[J];中國(guó)民族民間醫(yī)藥;2012年10期

8 高仲錄;閆衛(wèi)紅;張文秀;;柴精湯加味治療腦震蕩后遺癥52例[J];現(xiàn)代中醫(yī)藥;2011年05期

9 陳少仕;;逍遙散加味治療頑固性失眠50例體會(huì)[J];山東醫(yī)藥;2011年33期

10 王曉凱;;逍遙散治療心臟神經(jīng)官能癥臨床研究[J];中國(guó)醫(yī)學(xué)創(chuàng)新;2011年19期

，

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