發(fā)布時(shí)間：2018-01-26 04:23

  本文關(guān)鍵詞： 冷覺(jué)感受器受體M8 骨性關(guān)節(jié)炎 疼痛抑制 TRPM8表達(dá)　出處：《山西醫(yī)科大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:研究骨性關(guān)節(jié)炎患者疼痛抑制中TRPM8表達(dá)的臨床意義。方法:本實(shí)驗(yàn)選擇成年健康SD大鼠(共32只)為研究對(duì)象,首先行鞘內(nèi)置管,并使用弗氏佐劑建立骨性關(guān)節(jié)炎的大鼠模型,再將其分為NS-NS組、CFA-NS組、CFA-Menthol組和NS-Menthol組,共4組,每組各8只,在用藥前后觀察大鼠行為學(xué)指標(biāo)并檢測(cè)TRPM8表達(dá)。結(jié)果:CFA-Menthol組大鼠在給藥前后,大鼠的抬爪次數(shù)、熱痛敏分?jǐn)?shù)和機(jī)械痛敏闕值比較差異有統(tǒng)計(jì)學(xué)意義,P0.05。另外CFA-NS組、CFA-Menthol組大鼠TRPM8表達(dá)明顯高于NS-NS組、NS-Menthol組,P0.05。結(jié)論:TRPM8受體可被薄荷醇激活是以加強(qiáng)冷覺(jué)過(guò)敏并發(fā)揮冷鎮(zhèn)痛效果。
[Abstract]:Objective: to study the clinical significance of TRPM8 expression in pain suppression in patients with osteoarthritis. Methods: 32 adult SD rats were selected. The rat model of osteoarthritis was established with Freund's adjuvant, and then divided into 4 groups: NS-NS group, CFA-NS group, CFA-Menthol group and NS-Menthol group. Eight rats in each group were observed the behavioral indexes and the expression of TRPM8 before and after administration. Results the paw lifting times of rats in the 20% CFA-Menthol group were observed before and after administration. There was significant difference in thermal sensitivity score and mechanical pain sensitivity threshold between two groups (P 0.05). In addition, CFA-NS group. The expression of TRPM8 in CFA-Menthol group was significantly higher than that in NS-NS group. Conclusion: TPM 8 receptor can be activated by menthol in order to enhance cold allergy and exert cold analgesia.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R684.3

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

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本文編號(hào)：1464664