本文關(guān)鍵詞： 右美托咪定 顱內(nèi)動脈瘤 介入栓塞 血流動力學(xué)　出處：《中國老年學(xué)雜志》2017年09期 　論文類型：期刊論文

【摘要】：目的觀察介入栓塞治療老年顱內(nèi)動脈瘤輔助使用右美托咪定的臨床療效,分析其對血流動力學(xué)及術(shù)后應(yīng)激的影響。方法接受介入栓塞治療的老年顱內(nèi)動脈瘤患者使用右美托咪定49例為觀察組及不使用50例為對照組。結(jié)果觀察組丙泊酚(t=6.426,P0.01)及瑞芬太尼(t=2.712,P0.01)使用量均顯著低于對照組。兩組各指標在麻醉前均無顯著差異(P0.05)。觀察組平均動脈壓(MAP)、顱內(nèi)壓(ICP)及心率(HR)在麻醉滿意后、栓塞顱內(nèi)動脈瘤后、手術(shù)結(jié)束時均顯著低于對照組(P0.05)。兩組術(shù)后C反應(yīng)蛋白(CRP)及白細胞介素(IL)-6水平均顯著高于術(shù)前(P0.05),但觀察組術(shù)后CRP及IL-6水平均顯著低于對照組(P0.05)。結(jié)論采用介入栓塞治療老年顱內(nèi)動脈瘤中輔助使用右美托咪定有利于維持血流動力學(xué)穩(wěn)定及抑制術(shù)后應(yīng)激水平。
[Abstract]:Objective to observe the clinical effect of interventional embolization in elderly patients with intracranial aneurysms treated with dexmetomidine. Methods 49 elderly patients with intracranial aneurysms treated by interventional embolization were treated with dexmetomidine as observation group and 50 patients as control group. Phenols (. Tl 6.426. P 0.01) and remifentanil 2.712. The usage of P0.01) was significantly lower than that of the control group. There was no significant difference between the two groups before anesthesia. The mean arterial pressure (MAPP) of the observation group was lower than that of the control group (P 0.01). Intracranial pressure (ICP) and heart rate (HRR) after anesthesia were satisfactory, after embolization of intracranial aneurysms. At the end of operation, the levels of C-reactive protein (CRP) and interleukin-6 (IL-6) were significantly lower than those in control group (P 0.05). However, the levels of CRP and IL-6 in the observation group were significantly lower than those in the control group (P 0.05). Conclusion the adjunctive use of dexmetomidine in the treatment of elderly intracranial aneurysms by interventional embolization is helpful to maintain hemodynamic stability and inhibit postoperative stress.
【作者單位】： 山東省交通醫(yī)院神經(jīng)外科;
【基金】：山東省醫(yī)藥衛(wèi)生科技項目(No.2009QW015)
【分類號】：R614
【正文快照】： 顱內(nèi)動脈瘤并非實際意義上的腫瘤,特指發(fā)生在顱內(nèi)動脈血管壁上的異常膨出〔1〕。該病的發(fā)病機制并不完全明確,目前認為是顱內(nèi)血管壁先天性缺陷及管腔內(nèi)壓力過大等多引發(fā)〔2,3〕,顱內(nèi)動脈瘤主要累及老年人群〔4〕。以往常采用開顱手術(shù)治療顱內(nèi)動脈瘤,但隨著微創(chuàng)外科的發(fā)展,血管

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