發(fā)布時(shí)間：2018-01-01 05:01

  本文關(guān)鍵詞：條件性刺激誘導(dǎo)大鼠建立異丙酚復(fù)吸行為　出處：《溫州醫(yī)科大學(xué)學(xué)報(bào)》2016年12期 　論文類型：期刊論文

  更多相關(guān)文章： 異丙酚 復(fù)吸 環(huán)境線索 自身給藥

【摘要】：目的:利用條件性刺激誘導(dǎo)大鼠建立異丙酚復(fù)吸行為。方法:在固定比率(FR=1)程序下連續(xù)訓(xùn)練14 d建立自身給藥,大鼠24只,隨機(jī)分為3組(n=8):戒斷1 d(R1)組、戒斷14 d(R14)組和戒斷30 d(R30)組。大鼠進(jìn)行復(fù)吸測(cè)試2 h(前1 h為實(shí)驗(yàn)籠空間環(huán)境誘導(dǎo),后1 h為條件性刺激誘導(dǎo)),記錄動(dòng)物在2 h內(nèi)的有效或無(wú)效鼻觸數(shù)。結(jié)果:異丙酚自身給藥訓(xùn)練14 d,建立了穩(wěn)定的異丙酚靜脈自身給藥行為。和無(wú)效鼻觸相比,有效鼻觸數(shù)明顯增加,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。與R1組比,R14組有效鼻觸數(shù)顯著升高,差異有統(tǒng)計(jì)學(xué)意義(P0.01),R30組有效鼻觸數(shù)亦升高,但差異無(wú)統(tǒng)計(jì)學(xué)意義(P=0.057)。條件性刺激誘導(dǎo)的有效鼻觸反應(yīng)比實(shí)驗(yàn)籠空間環(huán)境的誘導(dǎo)作用更強(qiáng)烈(P0.05)。結(jié)論:條件性刺激可以誘導(dǎo)大鼠建立異丙酚復(fù)吸行為,異丙酚具有明顯的復(fù)吸特性。
[Abstract]:Objective: to induce propofol relapse in rats by conditioned stimulation. Methods: 24 rats were treated with propofol for 14 days. They were randomly divided into 3 groups: one day after abstinence and one day after abstinence. The rats were given relapse test for 2 hours (the first 1 hour was induced by the space environment of the experimental cage, and the latter 1 hour was induced by conditioned stimulation). Results: after 14 days of self-administration of propofol, the stable self-administered behavior of propofol was established, which was compared with that of ineffective nasal contact. Compared with R1 group, the effective nasal touch number of R14 group increased significantly (P 0.01). The number of effective nasal contacts in R30 group was also increased. But the difference was not statistically significant. The effective nasal contact response induced by conditioned stimulus was stronger than that induced by space environment of experimental cage (P0.05). Conclusion: conditioned stimulation can induce propofol relapse in rats. Propofol has obvious relapse characteristics.
【作者單位】： 溫州醫(yī)科大學(xué)附屬第二醫(yī)院麻醉科;寧波大學(xué)行為神經(jīng)科學(xué)研究中心寧波戒毒研究中心;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(81271469) 溫州市科技局科研基金資助項(xiàng)目(Y20140692,H20100060) 浙江省醫(yī)藥衛(wèi)生科技項(xiàng)目(2014KYB161)
【分類號(hào)】：R614
【正文快照】： 2016-01-15異丙酚是常用的靜脈麻醉藥物,廣泛用于麻醉和ICU鎮(zhèn)靜。異丙酚可以產(chǎn)生欣快感、愉悅和性興奮,具有明顯的獎(jiǎng)賞效應(yīng)[1-3]。有文獻(xiàn)[4]報(bào)道異丙酚依賴患者1 d需要注射藥物100多次,也有患者戒斷后出現(xiàn)復(fù)吸。這些證據(jù)表明異丙酚具有明顯的精神依賴性,存在復(fù)吸現(xiàn)象。條件性

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