【摘要】：反流是左心室輔助裝置(LVAD)在運行過程中轉(zhuǎn)速過低時出現(xiàn)的一種異常工況,會導(dǎo)致LVAD無法輔助自然心臟泵血,影響患者健康。根據(jù)反流程度的不同,本文定義了三種LVAD反流狀態(tài):無反流、輕度反流和重度反流,并基于動態(tài)封閉容腔理論,提出反流系數(shù)(RI)對其進行分級。數(shù)值結(jié)果表明,患者處于運動、靜息和睡眠狀態(tài)時,無反流和輕度反流的臨界轉(zhuǎn)速分別為6 650 r/min(運動)、7 000 r/min(靜息)和7 250 r/min(睡眠狀態(tài)),對應(yīng)RI值為0.401、0.300和0.238;輕度和重度反流的臨界轉(zhuǎn)速分別為5 500 r/min(運動)、6 000 r/min(靜息)和6 450 r/min(睡眠狀態(tài)),對應(yīng)RI值為0.488、0.359和0.284。此外,RI與轉(zhuǎn)速呈負相關(guān),確定相應(yīng)的臨界轉(zhuǎn)速即可實現(xiàn)LVAD反流的分級。因此本文研究結(jié)果顯示,基于流量信號的檢測參數(shù)RI能有效地區(qū)分LVAD的反流狀態(tài),便于LVAD的反流檢測,為LVAD的高可靠性控制系統(tǒng)的制定提供理論依據(jù)和技術(shù)支持。
[Abstract]:Reflux is an abnormal condition that occurs when the speed of the left ventricular assist device (LVAD) is too low during operation, which can lead to the inability of the LVAD to assist the blood of the natural heart pump and to affect the patient's health. According to the different degree of reflux, three LVAD reflux states were defined in this paper: no reflux, mild reflux and severe reflux, and based on the dynamic closed volume theory, the reflux coefficient (RI) was proposed to be classified. The results showed that the critical speeds of non-reflux and mild reflux were 6650 r/ min (exercise),7 000 r/ min (rest) and 7 250 r/ min (sleep state), and the corresponding RI value was 0.401, 0.300 and 0.238, respectively. The critical speeds of mild and severe reflux were 5 500 r/ min (exercise),6 000 r/ min (rest) and 6 450 r/ min (sleep state), and the corresponding RI value was 0.488, 0.359 and 0.284, respectively. In addition, there is a negative correlation between the RI and the rotational speed, and the classification of LVAD reflux can be achieved by determining the corresponding critical speed. Therefore, the results of this paper show that the flow signal-based detection parameter (RI) can be used to distinguish the back-flow state of LVAD in the effective area, and it is convenient to detect the LVAD, and provide the theoretical basis and technical support for the development of the high-reliability control system of LVAD.
【作者單位】： 江蘇大學(xué)電氣信息工程學(xué)院生物醫(yī)學(xué)工程系;江蘇大學(xué)流體機械工程技術(shù)研究中心生物醫(yī)學(xué)工程系;江蘇大學(xué)電氣信息工程學(xué)院電氣工程及其自動化系;
【基金】：國家自然基金資助項目(51677082,51477068,31600794) 江蘇省自然科學(xué)基金項目(BK20130539)
【分類號】：R318

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1 王惠蓀,金永安,秦家楠,蘭錫純;左心室輔助裝置研究中的掃描電鏡觀察[J];生物醫(yī)學(xué)工程學(xué)雜志;1989年01期

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本文編號：2447629