【摘要】：多孔鈦合金(p Ti)是目前較為理想的骨替代修復(fù)材料,但其在微觀水平上仍難以與骨組織充分骨整合。為此,研究了脈沖電磁場(PEMF)協(xié)同p Ti作用對兔長骨缺損的修復(fù)效果。采用電子束熔融技術(shù)制備孔隙率70%的Ti6Al4V多孔鈦合金圓棒;于12只成年兔股骨外側(cè)髁構(gòu)建骨缺損,填充以p Ti,并采用自行研制的基于"3-Helm Holz線圈"的電磁發(fā)生系統(tǒng)產(chǎn)生2 m T、15 Hz的PEMF進(jìn)行實(shí)驗(yàn)。結(jié)果表明:與單獨(dú)的p Ti作用相比,在PEMF和p Ti的協(xié)同作用下,6周后,p Ti中的骨體積百分比提高了78.5%,骨小梁數(shù)量提高了21.7%,骨小梁厚度增大了41.8%,骨小梁間隙減小了30.7%,骨表面積密度減少了36.2%。因此,PEMF顯著提高了p Ti的骨缺損修復(fù)效率,PEMF協(xié)同p Ti作用是一種更為高效的長骨缺損修復(fù)方法。
[Abstract]:Porous titanium alloy (p Ti) is an ideal bone replacement material at present, but it is still difficult to integrate fully with bone tissue at microcosmic level. The effect of pulsed electromagnetic field (PEMF) combined with p Ti on repairing rabbit long bone defect was studied. Ti6Al4V porous titanium alloy rod with 70% porosity was prepared by electron beam melting technique. A bone defect was constructed on the lateral femoral condyle of 12 adult rabbits. The bone defect was filled with p Ti, and the PEMF was produced by the electromagnetic generation system based on the "3-Helm Holz coil" for 2 t ~ 15 Hz. The results showed that the percentage of bone volume in, p Ti increased 78.5%, the number of trabecular bone increased 21.7% and the thickness of trabecular bone increased 41.8% in, p Ti after 6 weeks compared with p Ti alone, and the results showed that the percentage of bone volume in, p Ti increased by 78.5%, the number of trabecular bone increased by 21.7%, and the thickness of trabecular bone increased by 41.8%. Trabecular space decreased by 30.7 and bone surface density decreased by 36.2. Therefore, PEMF can significantly improve the repair efficiency of bone defect of p Ti. PEMF combined with p Ti is a more efficient method for repairing long bone defect.
【作者單位】： 第四軍醫(yī)大學(xué)生物醫(yī)學(xué)工程系;第四軍醫(yī)大學(xué)西京醫(yī)院骨科;
【基金】：國家自然科學(xué)基金(81471806;31270889) 陜西省自然科學(xué)基金(2014JQ4139)~~
【分類號】：R683;R318.08

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