【摘要】：目的該實驗通過測試不同劑量木糖醇對慶大霉素骨水泥不同時間點抗生素釋出量及試件生物力學強度,初步探討木糖醇添加劑對慶大霉素骨水泥的體外釋放及生物力學的影響,為臨床應用抗生素骨水泥提供實驗依據(jù)。方法將不同配比的抗生素骨水泥40 g添加11及22 g木糖醇并與對照組共分為6組。應用不銹鋼模具制成圓柱體標準試件,于萬能試驗機上以20 mm/min的速度對試件施加壓應力,試件破壞時計算機自動輸出最大載荷數(shù)據(jù)。骨水泥板條放入萬能力學機后,測量彎曲強度和彎曲模量。結果隨著慶大霉素添加劑量的增加(即1.0 g→2.0 g),慶大霉素骨水泥的釋放逐漸增多,各水平慶大霉素骨水泥的壓縮強度、彎曲模量、彎曲強度逐漸減少。隨著添加木糖醇劑量的增加(即11 g→22 g),骨水泥慶大霉素的釋放逐漸增多,并能延續(xù)4周以上,慶大霉素骨水泥的壓縮強度、彎曲模量、彎曲強度沒有顯著改變。結論添加木糖醇并不會顯著影響慶大霉素骨水泥的力學性能,能有效促進慶大霉素從骨水泥中持續(xù)釋放。
[Abstract]:Objective to investigate the effect of xylitol additive on the in vitro release and biomechanics of gentamicin bone cement by measuring the antibiotic release and biomechanical strength of gentamicin bone cement at different time points. To provide experimental basis for clinical application of antibiotic bone cement. Methods 40 g of antibiotic bone cement was added with 11 and 22 g xylitol and divided into 6 groups. The cylinder standard specimen was made by using stainless steel mould. The compressive stress was applied to the specimen at a speed of 20 mm/min on the universal testing machine. The computer automatically output the maximum load data when the specimen was destroyed. The bending strength and modulus were measured after the bone cement strip was put into the universal mechanical machine. Results with the increase of the amount of gentamicin additive (1.0 g / 2. 0 g), the release of gentamicin bone cement gradually increased, and the compression strength, flexural modulus and bending strength of gentamicin bone cement decreased gradually. With the increase of the dosage of xylitol (11 g / 22 g), the release of gentamicin increased gradually and lasted for more than 4 weeks. The compressive strength, flexural modulus and flexural strength of gentamicin bone cement did not change significantly. Conclusion the addition of xylitol can not significantly affect the mechanical properties of gentamicin bone cement, but can effectively promote the sustained release of gentamicin from bone cement.
【作者單位】： 西安醫(yī)學院第一附屬醫(yī)院;西安交通大學第二附屬醫(yī)院;
【分類號】：R318.01

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