【摘要】：羥基磷灰石(HAP)具有良好的生物活性和生物相容性,是人類的牙齒和骨骼的主要無機(jī)礦物組成,在生物材料中占有重要的地位。近年來科技工作者已經(jīng)合成了多種形態(tài)的HAP材料,例如：HAP非晶材料,HAP微球材料,HAP介孔材料,HAP晶須材料,HAP纖維材料等。由于臨床上需要大量的人體硬組織替代材料,及人體植入體,而植入體與人體組織物理化學(xué)屬性并不相同,需要在植入體的外面涂覆一層生物相容性好的HAP材料,目前常見的植入體材料包括：鈦基合金、不銹鋼、生物陶瓷等。人們齲病的常見性和多發(fā)性引起人們的重視,對牙釉質(zhì)進(jìn)行原位仿生再礦化是當(dāng)前研究的熱點(diǎn)內(nèi)容。 本文分別采用化學(xué)沉淀法、模擬體液法、共沉淀法、明膠凝膠法制備了普通羥基磷灰石粉體、磁性羥基磷灰石粉體、板條狀氟羥基磷灰石粉體。以硫酸亞鐵為添加劑,與HAP共沉淀,可以制備出磁性羥基磷灰石,晶粒細(xì)小分散性很好,有作為靶向載藥材料的潛力。設(shè)計(jì)了一種新的方法來制備羥基磷灰石微球,利用在化學(xué)沉淀法中制備的HAP粉體制備了一定pH值的懸濁液,通過調(diào)節(jié)pH值制備了HAP中空微球,HAP中空有核微球,HAP實(shí)心微球。 研究了硬脂酸鋁、十六胺、十二烷基硫酸鈉和山梨醇對羥基磷灰石晶體生長的影響,反應(yīng)原料為氯化鈣和磷酸氫二鈉,其反應(yīng)初始m(Ca)/m(P)為5：3,按照不同濃度加入外加劑,研究在多種介質(zhì)下HAP顆粒的生長,并對晶粒進(jìn)行了表征。 采用高能球磨法,以分析純的Ti粉和AI粉為原料,制備了金屬間化合物Ti3Al,并以在模擬體液中制備的HAP粉體為基體,Ti3Al為第二相,制備了Ti3Al/HAP復(fù)合材料,燒結(jié)溫度分別為1000℃、1050℃和1100℃,并對其進(jìn)行力學(xué)性能檢測.力學(xué)測試結(jié)果顯示Ti3Al/HAP復(fù)合材料的力學(xué)性能并沒有顯著提高,抗彎強(qiáng)度均比純HAP陶瓷低,而燒結(jié)溫度為1100℃,Ti3Al摻入量為1%的試樣斷裂韌性值最高。 分別在硅片、Ti3Al/HAP復(fù)合材料和牙切片上進(jìn)行了涂層制備。研究結(jié)果顯示通過電泳沉積法可以在硅片上制備出HAP的涂層,涂層的晶粒生長復(fù)合臺階式生長,每當(dāng)臺階沿著晶面掃過一次,則晶體就長大了一層。以螯合劑EDTA-2Na為媒介,可分別在Ti3Al/HAP復(fù)合材料和牙釉質(zhì)的表面制備出鈣磷礦物涂層,涂層由六方棱柱狀晶體組成,適當(dāng)延長礦化時(shí)間和礦化溫度,制備的涂層晶粒垂直于基底材料平行排列。采用酸性糊劑法可以在牙釉質(zhì)的表面制備出一層致密的由細(xì)小晶粒組成的涂層,在一定pH值范圍內(nèi),該涂層與酸性糊劑的pH值大小無關(guān)。
[Abstract]:Hydroxyapatite (HAP) has good bioactivity and biocompatibility. It is the main inorganic mineral composition of human teeth and bone and plays an important role in biomaterials. In recent years, many kinds of HAP materials have been synthesized, such as HAP amorphous material, HAP microsphere material, HAP mesoporous material, HAP whisker material, HAP fiber material and so on. Because a large number of human hard tissue substitute materials and human implants are needed clinically, and the physical and chemical properties of implants and human tissues are not the same, it is necessary to coat the implant with a layer of biocompatible HAP material. The commonly used implant materials include titanium alloy, stainless steel, bioceramics and so on. People pay more attention to the commonness and frequency of dental caries, and in situ biomimetic mineralization of tooth enamel is a hot topic. In this paper, common hydroxyapatite powder, magnetic hydroxyapatite powder and strip fluorohydroxyapatite powder were prepared by chemical precipitation method, simulated body fluid method, co-precipitation method and gelatin gel method. Magnetic hydroxyapatite can be prepared by co-precipitation of ferrous sulfate with HAP. The fine and dispersible grains have the potential to be used as targeted drug loading materials. A new method was designed to prepare hydroxyapatite microspheres. HAP powders prepared by chemical precipitation method were used to prepare suspensions with certain pH value. HAP hollow microspheres, HAP hollow nucleated microspheres and HAP solid microspheres were prepared by adjusting pH value. The effects of aluminum stearate, hexadecylamine, sodium dodecyl sulfate and sorbitol on the growth of hydroxyapatite crystals were studied. The raw materials of the reaction were calcium chloride and disodium hydrogen phosphate. The initial m (Ca) / m (P) ratio of the reaction was 5: 3. The growth of HAP particles in a variety of media was studied according to the addition of additives at different concentrations, and the grain size was characterized. The intermetallic compound Ti3Al, was prepared by high energy ball milling with pure Ti powder and AI powder as raw material. The Ti3Al/HAP composite was prepared by using HAP powder prepared in simulated body fluid as matrix and Ti3Al as the second phase. The sintering temperature is 1000 鈩，

本文編號：2336460