【摘要】：背景:傳統(tǒng)修復(fù)胸壁缺損的材料由于無法降解,需要長期留在體內(nèi)且組織反應(yīng)較大,并發(fā)癥發(fā)生率較高,難以滿足修復(fù)的需要。目的:制備生物可降解網(wǎng)狀人工胸壁,分析其性能及在胸壁缺損中的應(yīng)用效果。方法:將蠶絲纖維來源與聚己內(nèi)酯熔融共混,制備生物可降解網(wǎng)狀人工胸壁材料,檢測其孔隙率與彈性模量。取22只家兔,建立胸壁缺損模型,隨機(jī)分2組,實(shí)驗(yàn)組置入生物可降解網(wǎng)狀人工胸壁材料,對照組置入聚己內(nèi)酯材料,置入后4周,蘇木精-伊紅染色觀察缺損部位;置入后2個(gè)月,CT檢查骨缺損部位。結(jié)果與結(jié)論:(1)生物可降解網(wǎng)狀人工胸壁材料孔洞分布較均勻,孔隙率為54.4%,直徑200-300μm,材料中纖維分布相對穩(wěn)定,彈性模量高于聚己內(nèi)酯(P0.05);(2)CT顯示,實(shí)驗(yàn)組材料與肋骨斷端緊密接觸,胸壁板與臟層胸膜之間出現(xiàn)新生組織;對照組材料與斷端處接觸,邊界不清,存在高密度影;(3)蘇木精-伊紅染色顯示,實(shí)驗(yàn)組有大量纖維細(xì)胞,膠原纖維較疏松,炎細(xì)胞數(shù)少;對照組纖維肌膜與肌肉邊界不清,存在水腫,有較多炎細(xì)胞浸潤;(4)結(jié)果表明:生物可降解網(wǎng)狀人工胸壁可促進(jìn)缺損胸壁的修復(fù)。
[Abstract]:Background: the traditional materials for the repair of chest wall defects need to remain in the body for a long time and have a large tissue reaction due to their non-degradability. The incidence of complications is high and it is difficult to meet the needs of repair. Objective: to prepare biodegradable reticular artificial chest wall and analyze its performance and application effect in chest wall defect. Methods: the silk fiber was blended with polycaprolactone to prepare biodegradable reticulated artificial chest wall material and its porosity and elastic modulus were measured. 22 rabbits were randomly divided into two groups: the experimental group was implanted with biodegradable reticular artificial chest wall and the control group was implanted with polycaprolactone. The defect site was observed by hematoxylin-eosin staining 4 weeks after implantation. Two months after implantation, the site of bone defect was examined by CT. Results and conclusion: (1) the pore distribution of biodegradable reticular artificial chest wall was uniform, the porosity was 54.4, the diameter was 200-300 渭 m, the fiber distribution was relatively stable, and the elastic modulus was higher than that of polycaprolactone (P0.05); (2) CT. The experimental group was in close contact with the broken end of rib. The new tissue appeared between the pleural wall and the visceral pleura; in the control group, the contact between the material and the broken end was not clear and there were high density shadows; (3) there were a large number of fibrous cells in the experimental group, the collagen fibers were loose, and the number of inflammatory cells was less; In the control group, the boundary between fibromyomembrane and muscle was not clear, there were edema and inflammatory cell infiltration. (4) the results showed that the biodegradable reticular artificial chest wall could promote the repair of the defect chest wall.
【作者單位】： 南陽市中心醫(yī)院;克拉瑪依市中心醫(yī)院;新疆醫(yī)科大學(xué)第一附屬醫(yī)院;
【分類號】：R318.08;R655

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