【摘要】：復(fù)合牙科材料是指一種由基體樹脂和無機填料以及引發(fā)體系等混合均勻后固化而成的牙科材料。20世紀60年代雙酚A甲基丙烯酸縮水甘油酯(Bis-GMA)逐漸成為一種常用的牙科復(fù)合材料基體樹脂。但牙科修復(fù)材料與牙齒之間的裂痕,以及細菌在牙科修復(fù)體上的滋生,導(dǎo)致了繼發(fā)齲的出現(xiàn)和牙髓的損壞。因此,具有抗菌功能的牙科修復(fù)材料有良好的應(yīng)用前景。 本文以Bis-GMA和雙甲基丙烯酸二縮三乙二醇酯(TEGDMA)為樹脂基體,納米8i02為無機填料,用甲基丙烯酸縮水甘油酯(GMA)對具有高效廣譜抗菌性能的聚六亞甲基胍鹽酸鹽(PHMG)進行端基修飾,使其帶上具有反應(yīng)活性的C=C雙鍵。然后分別使用化學(xué)固化和紫外固化法制備了牙科復(fù)合樹脂,并對復(fù)合樹脂的抗菌性能、力學(xué)性能和固化情況進行了考察。 分別采用馬來酸酐(MAH)和甲基丙烯酸縮水甘油酯(GMA)對PHMG的端基進行修飾。通過紅外光譜和核磁共振氫譜分析了所得產(chǎn)物的結(jié)構(gòu)及端基修飾情況。結(jié)果表明：MAH和GMA都可以對PHMG進行端基修飾。由于GMA修飾的PHMG更有利于牙科復(fù)合樹脂的制備,因此主要采用GMA端基修飾的PHMG-GMA制備牙科復(fù)合樹脂。 將PHMG-GMA、Bis-GMA、TEGDMA和Si02以及引發(fā)劑以適當(dāng)?shù)谋壤{(diào)配,然后進行固化。用偶氮二異丁腈(AIBN)作引發(fā)劑制得的復(fù)合樹脂,PHMG-GMA的加入基本不影響復(fù)合材料的力學(xué)性能；8i02的加入會降低復(fù)合樹脂的彎曲強度,但可以提高壓縮強度和硬度。含1.0%PHMG-GMA的復(fù)合樹脂具有非常優(yōu)異的抗變形鏈球菌的能力,抗菌率達99.99%。以樟腦醌(CQ)為引發(fā)劑進行紫外光固化,同樣也可以得到具抗菌功能的牙科復(fù)合樹脂,對大腸桿菌的抗菌率在99.0%以上,顯示了非常好的抗菌效果。
[Abstract]:Composite dental material is a kind of dental material which is cured by mixing matrix resin, inorganic filler and initiator system. In the 1960s, bisphenol A glycidyl methacrylate (Bis-GMA) gradually became a common kind of dental material. Dental composite matrix resin. But the cracks between dental restorations and teeth, as well as the growth of bacteria in dental restorations, lead to secondary caries and pulp damage. Therefore, dental restorative materials with antimicrobial function have a good application prospect. In this paper, Bis-GMA and diethylene glycol dimethacrylate (TEGDMA) were used as resin matrix, nanometer 8i02 was used as inorganic filler, glycidyl methacrylate (GMA) was used to modify polyhexamethylguanidine hydrochloride (PHMG), which had high antimicrobial activity. C C double bond with reactive activity was carried on it. Then the dental composite resin was prepared by chemical curing and UV curing, and the antibacterial properties, mechanical properties and curing conditions of the composite resin were investigated. The terminal groups of PHMG were modified by maleic anhydride (MAH) and glycidyl methacrylate (GMA). The structure and end-group modification of the products were analyzed by IR and NMR spectra. The results show that PHMG can be modified by GMA and GMA. Because GMA modified PHMG is more favorable to the preparation of dental composite resin, GMA terminal modified PHMG-GMA is mainly used to prepare dental composite resin. PHMG-GMA,Bis-GMA,TEGDMA, Si02 and initiator were prepared in an appropriate proportion and then solidified. The addition of PHMG-GMA to the composite resin prepared by using azodiisobutyronitrile (AIBN) as initiator has little effect on the mechanical properties of the composite material. The addition of 8i02 can decrease the bending strength of the composite resin, but it can improve the compressive strength and hardness of the composite resin. The composite resin containing 1.0%PHMG-GMA has excellent ability to resist streptococcus mutans and its antibacterial rate is 99.99%. The dental composite resin with antibacterial function can also be obtained by UV curing with camphor quinone (CQ) as initiator. The antibacterial rate against Escherichia coli is more than 99.0%, showing a very good antibacterial effect.
【學(xué)位授予單位】：華東理工大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R318.08

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