發(fā)布時間：2018-07-28 10:57

【摘要】：低溫微創(chuàng)療法治療腫瘤以其良好的治療效果和巨大的應(yīng)用前景正在受到越來越多的重視。目前廣泛使用的冷凍治療設(shè)備中，氬氦冷凍治療系統(tǒng)和其他相變冷凍治療設(shè)備在都存在著某些方面的局限性，從而限制了這種優(yōu)良的腫瘤治療方法的發(fā)展和應(yīng)用。本文的研究內(nèi)容正是為克服這種局限性而提出，旨在開發(fā)出一款基于液氮的制冷溫度低、冷凍速度快、手術(shù)創(chuàng)口小、運行成本低、操作簡便的微創(chuàng)冷刀治療系統(tǒng)。 作為冷刀治療系統(tǒng)前期研究的重要內(nèi)容，，本文將在冷刀系統(tǒng)軟硬件設(shè)計、離體組織的冷凍實驗、冷凍治療過程中組織溫度場分布等方面進(jìn)行深入研究： ①根據(jù)微創(chuàng)冷刀系統(tǒng)監(jiān)測和控制的需要，設(shè)計系統(tǒng)工作過程中的溫度實時檢測和顯示模塊，并在現(xiàn)有條件下，對該模塊的功能進(jìn)行實驗驗證；同時，研究冷熱交替治療過程中，冷凍過程和復(fù)溫過程的溫度控制策略； ②利用自主研究的冷刀系統(tǒng)，搭建實驗平臺，進(jìn)行離體豬肝的冷凍實驗，收集動物組織冷凍過程中的溫度數(shù)據(jù)，分析其溫度場的變化規(guī)律； ③在對生物傳熱學(xué)和生物傳熱模型進(jìn)行梳理研究的基礎(chǔ)上，根據(jù)對離體豬肝組織進(jìn)行冷凍的實驗事實，選擇建立離體豬肝組織合適的物理模型和數(shù)學(xué)模型，并運用FLUENT有限元分析軟件，進(jìn)行冷凍過程中豬肝組織內(nèi)溫度場分布的數(shù)值模擬，對數(shù)值模擬所采用的組織的熱物性參數(shù)進(jìn)行深入研究。 本文為液氮微創(chuàng)冷刀系統(tǒng)后續(xù)研究的開展奠定了基礎(chǔ)。
[Abstract]:Low temperature minimally invasive therapy for cancer is being paid more and more attention for its good therapeutic effect and great potential application. There are some limitations in the argon helium cryotherapy system and other phase change cryotherapy equipment in the widely used cryotherapy equipment, which restricts the excellent treatment of tumor. In order to overcome this limitation, the purpose of this study is to develop a minimally invasive cold knife treatment system based on low cooling temperature, fast freezing speed, small operation cost, low operation cost and easy operation.
As an important part of the early research of the cold knife treatment system, this paper will make a thorough study on the hardware and software design of the cold knife system, the freezing experiment of the tissue in vitro and the distribution of the temperature field in the process of freezing treatment.
According to the needs of the monitoring and control of the minimally invasive cold knife system, the temperature real-time detection and display module in the working process of the system is designed, and the function of the module is tested under the existing conditions. At the same time, the temperature control strategy of the freezing process and the rewarming process is studied in the process of alternating cold and heat treatment.
The experiment platform was built by using the independent cold knife system, the freezing experiment of pig liver in vitro was carried out, the temperature data during the freezing process of animal tissues were collected, and the change law of the temperature field was analyzed.
(3) on the basis of the study of biological heat transfer and biological heat transfer model, according to the experimental facts about the freezing of pig liver tissue in vitro, a suitable physical model and mathematical model of the isolated pig liver tissue is chosen, and the numerical model of the temperature field distribution in the liver tissues of the pig's liver during the freezing process is carried out by using the FLUENT finite element analysis software. The thermal physical parameters of the structure adopted in numerical simulation are studied in depth.
This study laid the foundation for the follow-up study of the liquid nitrogen minimally invasive cold knife system.
【學(xué)位授予單位】：重慶大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R318.6

【引證文獻(xiàn)】

相關(guān)期刊論文 前1條

1 王震;田學(xué)隆;倪潤明;童明偉;王槐志;;液氮冷凍刀溫度檢測與顯示系統(tǒng)實現(xiàn)[J];低溫與超導(dǎo);2013年11期

相關(guān)碩士學(xué)位論文 前3條

1 趙艷哲;低溫冷凍皮膚疾病治療過程建模及自動噴射系統(tǒng)研究[D];山東大學(xué);2015年

2 張穎慧;冷熱循環(huán)腫瘤治療設(shè)備的控制系統(tǒng)工程化設(shè)計與實現(xiàn)[D];重慶大學(xué);2015年

3 王震;液氮低溫微創(chuàng)冷凍刀設(shè)計與實驗研究[D];重慶大學(xué);2014年

本文編號：2149891