發(fā)布時間：2018-07-06 06:43

  本文選題：沙療 + 熱磁沙療��； 參考：《新疆大學(xué)》2017年碩士論文

【摘要】：近年來治療骨性關(guān)節(jié)炎(Osteoarthritis,OA)在臨床醫(yī)學(xué)領(lǐng)域上有了不少的成果。雖然治療骨性關(guān)節(jié)炎的物理療法的種類很多,但是各種治療方法的機理也不同。其中,埋沙療法是治療效果最有效的方法之一,沙體成分里有很多種磁性礦物質(zhì),并且已有很多實踐證明,各種磁療儀在治療骨疾病方面的治療效果確實很好。我們考慮這些原因,將沙療法和磁療法結(jié)合起來,研究對骨性關(guān)節(jié)炎的治療是否有耦合的積極作用,為臨床鄰域提供實驗依據(jù)。股骨是承受動物身體載荷的主要構(gòu)架,骨體積跟骨組織的功能和力學(xué)性能有密切的關(guān)系,所以本文主要分析了兩種治療法對軟質(zhì)骨、密質(zhì)骨和硬質(zhì)骨的骨量變化和它們之間的互相轉(zhuǎn)變及生物力學(xué)性能之間的關(guān)系,及其進行多物理場仿真和模擬計算熱場產(chǎn)生的熱應(yīng)力,并研究兩種治療的治療效果對OA兔子的骨量變化及力學(xué)性能的機理。本實驗選體重相近及健康的新西蘭雄性大白兔為實驗對象,實驗對象適應(yīng)新的環(huán)境后,實驗對象關(guān)節(jié)腔注射濃度為3%的Papain蛋白水解酶的方法建立OA模型,然后隨機分為沙療組和熱磁沙療組。利用電子計算機斷層掃描(CT)的技術(shù)獲取兔子掃描數(shù)據(jù),再利用醫(yī)學(xué)影像控制系統(tǒng)(Mimics)處理CT掃描數(shù)據(jù),獲取股骨各股質(zhì)層、肌肉和骨髓的體積及三維模型。通過做股骨的三點彎曲和壓縮實驗得到的力學(xué)性能指標及進行分析。實驗結(jié)果顯示兔子患OA后,比健康時軟質(zhì)骨的體積有了明顯的上升,硬質(zhì)骨的體積有了明顯的下降,進行治療后,發(fā)現(xiàn)軟質(zhì)骨的骨量逐漸減少,而硬質(zhì)骨的骨量增多。通過對比兩種治療后CT掃描數(shù)據(jù)結(jié)果,沙療組軟質(zhì)骨的骨量的減少量和硬質(zhì)骨骨量的增多量明顯大于熱磁沙療組軟質(zhì)骨骨量的減少量和硬質(zhì)骨骨量的增多量,完成相關(guān)的生物力學(xué)實驗后,發(fā)現(xiàn)沙療組的生物力學(xué)指標同樣大于熱磁沙療組。利用多物理場軟件對OA模型進行生物傳熱數(shù)值模擬。熱場產(chǎn)生的熱應(yīng)力改善了股骨力學(xué)功能的適應(yīng)性及促進了骨重建。我們最終得出的結(jié)論是:雖然兩種治療對OA兔子有了緩解作用,但是沙療比熱磁沙療的效果更明顯,原因很可能是我們的熱磁沙療儀未能使熱場和磁場結(jié)合一起,從而熱磁沙療組對OA兔子產(chǎn)生了消極作用。
[Abstract]:In recent years, the treatment of osteoarthritis (OA) has made a lot of achievements in the field of clinical medicine. Although there are many types of physiotherapy for osteoarthritis, the mechanisms of various treatments vary. Sand burying therapy is one of the most effective methods to treat bone diseases. There are many kinds of magnetic minerals in sand body. We consider these reasons and combine sand therapy with magnetic therapy to study whether there is a positive coupling effect on the treatment of osteoarthritis and provide experimental basis for clinical neighborhood. Femur is the main frame to bear animal body load. The function and mechanical properties of bone volume and calcaneal tissue are closely related, so this paper mainly analyzes the effect of two kinds of therapy on soft bone. The changes in bone mass of dense and hard bones and the relationship between their intertransformation and biomechanical properties, as well as the simulation and simulation of the thermal stresses generated by the thermal fields, The effects of two treatments on bone mass and mechanical properties of OA rabbits were studied. In this experiment, New Zealand male rabbits with similar weight and healthy weight were selected as experimental objects. After the subjects were adapted to the new environment, the OA model was established by injecting 3% Papain protein hydrolase into the articular cavity of the experimental subjects. Then they were randomly divided into sand therapy group and thermomagnetic sand therapy group. The scanning data of rabbits were obtained by computer tomography (CT), and the CT scanning data were processed by medical image control system (Mimics) to obtain the volume and 3D model of femoral layer, muscle and bone marrow. The mechanical properties of femur were analyzed by three-point bending and compression tests. The results showed that the volume of soft bone increased obviously and the volume of hard bone decreased obviously. After treatment, it was found that the amount of soft bone decreased gradually, but the amount of hard bone increased. By comparing the CT scan data after two kinds of treatments, the reduction of soft bone and the increase of hard bone in sand treatment group were obviously larger than those of soft bone and rigid bone in thermomagnetic sand treatment group. After completing the related biomechanical experiments, it was found that the biomechanical indexes of the sand therapy group were also higher than those of the thermomagnetic sand therapy group. The biological heat transfer of OA model was simulated by multi-physical field software. Thermal stress induced by thermal field improves the adaptability of femur mechanical function and promotes bone reconstruction. We finally concluded that although the two treatments had a palliative effect on OA rabbits, sand therapy was more effective than thermomagnetic sand therapy, probably because our thermomagnetic sand therapy instrument failed to combine the thermal field with the magnetic field. Thus the thermomagnetic sand therapy group had a negative effect on OA rabbits.
【學(xué)位授予單位】：新疆大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R684.3;R318.01

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