發(fā)布時(shí)間：2018-06-10 01:51

  本文選題：聚醚醚酮 + 鋇玻璃粉　； 參考：《吉林大學(xué)》2013年博士論文

【摘要】：聚醚醚酮（PEEK）具有良好的力學(xué)性能、化學(xué)穩(wěn)定性和生物相容性，可耐受高溫蒸汽和輻照消毒，這些優(yōu)良的特性使PEEK制成的椎間融合器材料獲得廣泛的臨床使用。然而，由于PEEK難以與市場(chǎng)上常見的口腔材料進(jìn)行良好的粘接，而且無法進(jìn)行術(shù)后的X射線檢驗(yàn)，熱膨脹系數(shù)牙齒相差較大，目前在口腔領(lǐng)域中，PEEK僅作為臨時(shí)冠材料被少量應(yīng)用。為了使PEEK在口腔領(lǐng)域獲得更加廣泛的應(yīng)用，本論文以改善PEEK材料力學(xué)性能、粘接性能、熱膨脹性能、X射線阻射性能和生物活性為目的，通過共混和表面涂層的手段，對(duì)PEEK材料進(jìn)行了改性。 首先，我們利用共混方式，通過改變鋇玻璃粉（BGF）的含量和粒徑，制備出了一系列聚醚醚酮/鋇玻璃粉（PEEK/BGF）復(fù)合材料。經(jīng)研究表明，隨著BGF填充含量的提高，材料與樹脂水門汀的粘接強(qiáng)度、X射線阻射性能都得到顯著的提高，材料的熱膨脹性能、力學(xué)性能和耐磨性也得到一定的改善。在粘接測(cè)試中，1μm粒徑的BGF制備復(fù)合材料與樹脂水門汀的粘接強(qiáng)度較高，隨著填料含量增加，粘接強(qiáng)度隨之增大。通過不同的處理方法，證實(shí)了材料與樹脂水門汀粘接的改善來源于BGF的充填。通過添加BGF，材料和摩擦面的真實(shí)接觸面積降低，，使得摩擦系數(shù)明顯下降。之后，通過二次雙螺桿擠出制備了不同填料比例的聚醚醚酮/鋇玻璃粉/玻璃纖維三元共混復(fù)合材料。玻纖的增強(qiáng)使材料的模量、熱膨脹性能和耐磨性得到進(jìn)一步提高。 為了改善材料的生物活性，本文使用了兩種方法將具有生物活性的納米羥基磷灰石(nHA)引入PEEK體系。方法一，使用熔融共混的方式制備了聚醚醚酮/納米羥基磷灰石(PEEK/nHA)復(fù)合材料。nHA的充填提高了材料的力學(xué)性能，但是材料的表面生物活性卻沒有得到明顯改善。通過表面元素分析證實(shí)，材料表面暴露的納米羥基磷灰石較少，可能是導(dǎo)致生物活性沒有明顯改善的主要原因。方法二，通過使用硅烷偶聯(lián)劑的方法，在PEEK/BGF復(fù)合材料表面構(gòu)建光固化涂層。涂層由具有生物活性的納米羥基磷灰石（nHA）和甲基丙烯酸酯類光固化樹脂復(fù)合而成。研究結(jié)果表明, nHA填充的光固化涂層使材料表面的生物活性得到提高。
[Abstract]:Polyether ether ketone (PEEK) has good mechanical properties, chemical stability and biocompatibility, and can withstand high temperature steam and irradiation disinfection. These excellent properties make PEEK interbody fusion cage material widely used in clinic. However, because peek is difficult to bond well with the common oral materials in the market and can not be examined by X-ray after operation, the coefficient of thermal expansion of teeth is quite different. At present, peek is only used as a temporary crown material in the field of stomatology. In order to obtain more extensive application of peek in the field of stomatology, the purpose of this paper is to improve the mechanical properties, adhesive properties, thermal expansion properties and X-ray resistance of peek materials. Firstly, a series of polyether ether ketone / barium glass powder PEEK / BGF composites were prepared by changing the content and particle size of barium glass powder. The results show that with the increase of the content of BGF, the bonding strength and X-ray resistance of the materials to the resin cement are improved significantly, and the thermal expansion, mechanical properties and wear resistance of the materials are also improved to a certain extent. The adhesive strength of the composite prepared with 1 渭 m diameter BGF was higher than that of the resin cement, and the bonding strength increased with the increase of filler content. Through different treatment methods, it is proved that the improvement of the bonding between the material and the resin cement comes from the filling of BGF. By adding BGF, the real contact area between the material and the friction surface is decreased, and the friction coefficient is obviously decreased. After that, polyether ether ketone / barium glass powder / glass fiber ternary composites with different filler ratios were prepared by twin-screw extrusion. In order to improve the bioactivity of the materials, two methods were used to introduce bioactive nano-hydroxyapatite into peek system. Methods 1. The filling of polyether ether ketone / nano-hydroxyapatite (PEEK / nHA) composite by melt blending improved the mechanical properties of the composite, but the surface biological activity of the composite was not obviously improved. The results of surface elemental analysis show that the low exposure of nano-hydroxyapatite on the surface of the material may be the main reason for the lack of significant improvement in biological activity. Secondly, the photocuring coating was constructed on the surface of PEEK / BGF composite by using silane coupling agent. The coating is composed of nano-hydroxyapatite with bioactivity and light curing resin of methacrylate. The results showed that the surface bioactivity of NHA-filled coatings was improved.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2013
【分類號(hào)】：R783.1

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