發(fā)布時間：2018-06-09 05:52

  本文選題：探針設計 + 數(shù)值模擬　； 參考：《上海交通大學》2012年碩士論文

【摘要】：腫瘤的冷熱交替治療可以克服單冷和單熱療法的不足,提高腫瘤的治愈率,同時可以保護正常的組織不受損害,已成為近年腫瘤熱物理治療研究的一個熱點方向。本實驗室自主研發(fā)的冷熱交替治療儀,用液氮作為冷媒制冷,射頻加熱。目前正在進行大量的動物實驗,但原有探針在進行動物實驗時存在治療探針不能與皮下腫瘤完全有效接觸,治療效果被削弱的問題。 本研究的主要目的是為冷熱交替治療系統(tǒng)研制新型的探針。針對動物實驗中不同類型、不同尺寸的腫瘤,設計并制造新型的治療探針,并增加測溫功能。 新型探針是基于數(shù)值模擬以設定探針參數(shù)。本研究通過精確建模和數(shù)值模擬,研究了內(nèi)管直徑、探針長度、入口壓力等因素對制冷效果的影響。發(fā)現(xiàn)較大的內(nèi)管直徑和較長的探針長度以及較高的入口壓力使治療探針的制冷能力增強。同時還研究了射頻對組織的作用,發(fā)現(xiàn)新型平面探針在加熱時由于對組織作用面積大,加熱均勻,不會產(chǎn)生組織的焦化現(xiàn)象。根據(jù)數(shù)值模擬優(yōu)選出達到最好療效的探針參數(shù),并考慮實際操作對探針尺寸的限制,本文最終確定了針對不同類型和尺寸腫瘤的探針參數(shù),并制作了相應的探針。通過對探針在膠體內(nèi)溫度場的直接測量,驗證了模擬結果的準確性。 新型探針被用于小鼠的皮下腫瘤治療,以及兔子肝臟腫瘤治療的研究。對移植過皮下腫瘤的小鼠進行過冷熱交替治療。通過對治療方案的不斷摸索,現(xiàn)在對直徑小于1cm的皮下腫瘤有較高的治愈率,約為87.5%。 新型探針是冷熱交替治療儀的重要組成部分,為研究冷熱交替療法治療各種腫瘤的效果提供硬件基礎。本文中對影響探針制冷效果的因素的討論,以及探針參數(shù)的選擇對今后設計醫(yī)用治療探針有重要借鑒意義。
[Abstract]:The alternative therapy of cold and heat can overcome the deficiency of single cold and single heat therapy, improve the cure rate of tumor and protect the normal tissue from damage. It has become a hot topic in the research of tumor thermophysiotherapy in recent years. Our laboratory developed an alternate cooling and heat therapy instrument, using liquid nitrogen as refrigerant and RF heating. At present, a large number of animal experiments are being carried out, but when the original probe is used in animal experiments, the therapeutic probe cannot be completely effectively contacted with the subcutaneous tumor. The main purpose of this study is to develop a new probe for alternate cold and heat therapy system. A new type of therapeutic probe is designed and manufactured for different types and sizes of tumors in animal experiments, and the function of temperature measurement is increased. The new probe is based on numerical simulation to set the probe parameters. Through accurate modeling and numerical simulation, the effects of inner tube diameter, probe length and inlet pressure on refrigeration effect were studied. It was found that the larger inner tube diameter, longer probe length and higher inlet pressure enhanced the cooling ability of the therapeutic probe. At the same time, the effect of RF on the tissue is studied. It is found that the new planar probe will not coking the tissue because of its large area and uniform heating. According to the numerical simulation, the best probe parameters were selected and the limit of the probe size was considered. Finally, the probe parameters for different tumor types and sizes were determined, and the corresponding probes were made. The accuracy of the simulation results was verified by the direct measurement of the temperature field of the probe in the colloid. The new probe was used in the treatment of subcutaneous tumor in mice and in the treatment of rabbit liver tumor. The mice transplanted with subcutaneous tumor were treated alternately between cold and heat. Through the continuous exploration of the treatment plan, there is a higher cure rate for subcutaneous tumors whose diameter is less than 1cm, which is about 87.5.The new probe is an important part of the alternately cold and hot therapeutic apparatus. To provide the hardware basis for the study of the effect of alternate cold and heat therapy on various kinds of tumors. In this paper, the factors affecting the cooling effect of the probe and the selection of the probe parameters are of great significance for the design of the medical therapeutic probe in the future.
【學位授予單位】：上海交通大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R318.6

【參考文獻】

相關碩士學位論文 前1條

1 董佳祥;冷熱交替熱物理治療引起小鼠乳腺癌抗腫瘤免疫響應研究[D];上海交通大學;2008年

，

本文編號：1999261