本文選題：地塞米松磷酸鈉 + 海藻酸鈉��； 參考：《中國生物醫(yī)學(xué)工程學(xué)報》2014年06期

【摘要】：研制新型醛基化海藻酸鈉-地塞米松緩釋涂層,篩選最佳涂層模式和涂層條件,對涂層穩(wěn)定性、抗凝性能、緩釋性能等進(jìn)行評價。高碘酸鈉氧化海藻酸鈉得醛基化海藻酸鈉(OSA),酸化預(yù)處理聚氯乙烯(PVC)管材表面,聚乙烯亞胺涂抹經(jīng)酸化預(yù)處理的PVC管材。聚乙烯亞胺涂層管材(PP)通過離子鍵直接交聯(lián)地塞米松磷酸鈉(DSP)制備DSP單涂層管材(PPD組),PP通過離子鍵交聯(lián)(PPI組)、共價鍵交聯(lián)(PPC組)兩種方式制備醛基化海藻酸鈉-地塞米松磷酸鈉復(fù)合涂層管材,同時設(shè)置空白對照(C組)。以正交實驗篩選3種涂層模式的最佳涂層條件。對3種涂層管材進(jìn)行涂層物定性和定量分析,抗凝、抗血小板、抗蛋白粘附、體外釋放等性能進(jìn)行評價研究,從而篩選最佳涂層模式。結(jié)果顯示,PPD、PPI和PPC等3種涂層模式均能固定DSP,最佳固定密度分別為(3.33±0.75)、(1.63±0.76)、(2.06±0.68)μg/cm2;復(fù)合涂層組(PPI和PPC)血小板粘附量(109/L)分別為(13.88±1.89)和(19.13±3.40),均較C組(41.38±3.20)顯著減少;復(fù)合涂層組蛋白粘附量(mg/cm2)(HAS:(29.86±13.57)和(46.67±3.20),HPF:(34.99±3.52)和(45.67±3.79)),均較PPD組(HAS:(68.73±4.26),HPF:(72.54±7.90))顯著減少;體外釋放方面PPC組明顯優(yōu)于PPI組。醛基化海藻酸鈉-地塞米松復(fù)合涂層具備良好的血液相容性和生物相容性,通過共價交聯(lián)的DSP能夠達(dá)到緩釋效果。
[Abstract]:A new alginate-dexamethasone sustained-release coating was developed. The optimum coating mode and coating conditions were selected. The stability, anticoagulant and slow-release properties of the coating were evaluated. Sodium periodate oxidized alginate to alginate sodium alginate, acidizing pretreatment PVC PVC pipe surface, polyethyleneimide coated PVC pipe after acidizing. Polyethyleneimine coated pipe (PPP) preparation of Dexamethasone Sodium Phosphate (DSPP) by ion bond direct cross-linking of Dexamethasone sodium phosphate (DSPs), preparation of alginate sodium alginate by ion bond crosslinking (PPI group, covalent bond crosslinking / PPC group) Dexamethasone sodium phosphate composite coating tube, At the same time, the blank control group C was set up. The optimum coating conditions of three kinds of coating modes were selected by orthogonal experiment. The qualitative and quantitative analysis, anticoagulant, anti-platelet, anti-protein adhesion and in vitro release of three kinds of coating tubes were evaluated and the best coating model was selected. The results showed that PPD-PPI and PPC could immobilize DSP.The optimum fixation density was 1.63 鹵0.76 (2.06 鹵0.68) 渭 g / cm ~ (2), and the platelet adhesion capacity of PPI and PPC in composite coating group was 13.88 鹵1.89) and 19.13 鹵3.40%, respectively, which was significantly lower than that in C group (41.38 鹵3.20). The amount of protein adhesion of the composite coating group was 29.86 鹵13.57), 46.67 鹵3.20% (34.99 鹵3.52) and 45.67 鹵3.79 (respectively), which was significantly lower than that of the PPD group (68.73 鹵4.26HPFV 72.54 鹵7.90), and the in vitro release of PPC group was better than that of PPI group. Aldose alginate-dexamethasone composite coating has good blood compatibility and biocompatibility.
【作者單位】： 天津市第三中心醫(yī)院心臟中心;天津市人工細(xì)胞重點實驗室;
【基金】：天津市科技支撐計劃重點項目(11ZCGYSY02000) 天津市衛(wèi)生局重點攻關(guān)項目(13KG110)
【分類號】：R318.08

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本文編號：1987432