本文選題：聽(tīng)覺(jué)神經(jīng)系統(tǒng) + 聽(tīng)覺(jué)穩(wěn)態(tài)反應(yīng)�。� 參考：《清華大學(xué)》2013年博士論文

【摘要】：聽(tīng)覺(jué)穩(wěn)態(tài)反應(yīng)（ASSR）是由周期性刺激聲音誘發(fā)的頭皮腦電信號(hào)，其特點(diǎn)是在較長(zhǎng)時(shí)段內(nèi)刺激頻率對(duì)應(yīng)的誘發(fā)成分能保持振幅和相位恒定，，一般認(rèn)為整個(gè)聽(tīng)覺(jué)神經(jīng)系統(tǒng)均與ASSR有關(guān)聯(lián)。聽(tīng)覺(jué)神經(jīng)系統(tǒng)除承擔(dān)聲音感知、認(rèn)知外，也是一條外部信息輸入通路，輸入信息在中樞神經(jīng)系統(tǒng)解碼、分析的過(guò)程中伴隨神經(jīng)電活動(dòng)，傳導(dǎo)到頭皮形成誘發(fā)腦電信號(hào)。 本文從大腦的聽(tīng)覺(jué)神經(jīng)系統(tǒng)生理結(jié)構(gòu)入手，系統(tǒng)地研究了聽(tīng)覺(jué)穩(wěn)態(tài)反應(yīng)用于檢測(cè)各級(jí)神經(jīng)中樞功能活動(dòng)的可行性。聽(tīng)覺(jué)穩(wěn)態(tài)反應(yīng)在聽(tīng)力檢測(cè)、麻醉檢測(cè)領(lǐng)域已有應(yīng)用，本論文提出了基于ASSR測(cè)量進(jìn)行臨床聽(tīng)覺(jué)相關(guān)腦功能與認(rèn)知功能分析，并通過(guò)若干實(shí)驗(yàn)研究驗(yàn)證其可行性。本文首先搭建了適合實(shí)驗(yàn)室與臨床的聽(tīng)覺(jué)穩(wěn)態(tài)反應(yīng)檢測(cè)平臺(tái)。研究了提高ASSR的檢測(cè)效率方法，通過(guò)對(duì)比分析篩選出最佳chirp信號(hào)作為ASSR的刺激聲。該信號(hào)的特點(diǎn)是能夠同時(shí)有效激勵(lì)耳蝸不同頻率神經(jīng)元。 結(jié)合改進(jìn)的相位分析方法進(jìn)行ASSR檢出應(yīng)用，將幅度信息、先驗(yàn)相位與相位分布統(tǒng)計(jì)綜合分析，在一定程度上縮短檢測(cè)時(shí)間并提高了準(zhǔn)確率。ASSR的頻率、幅度、相位與神經(jīng)系統(tǒng)功能有著密切相關(guān)性。當(dāng)各級(jí)神經(jīng)組織發(fā)生病變或異常，誘發(fā)腦電信號(hào)將出現(xiàn)相應(yīng)的變化，通過(guò)分析變化的趨勢(shì)、程度，可獲得神經(jīng)系統(tǒng)功能狀態(tài)，可以為臨床診療提供依據(jù)。在腦聽(tīng)覺(jué)功能臨床檢測(cè)中，通過(guò)對(duì)腦干損傷患者以及全麻患者ASSR分析表明，40Hz和90Hz的ASSR的信號(hào)幅度分別對(duì)腦干損傷和皮層腦功能抑制較為敏感。以刺激強(qiáng)度與ASSR反應(yīng)幅度的線性關(guān)系為特征，可實(shí)現(xiàn)腦干損傷與皮層功能抑制的有效分類(lèi)，為臨床快速判斷損傷部位提供定位參考。研究將gamma頻段ASSR應(yīng)用于臨床聽(tīng)力認(rèn)知功能檢測(cè)，提出幅度調(diào)制下的正反語(yǔ)音的刺激模式，并結(jié)合腦網(wǎng)絡(luò)分析與圖論分析方法。探討了正常受試與幻聽(tīng)受試在聽(tīng)力認(rèn)知過(guò)程中ASSR的能量分布與腦網(wǎng)絡(luò)連接出現(xiàn)明顯的差異性，結(jié)果解釋了幻聽(tīng)癥狀可能的神經(jīng)病理，表明ASSR可作為認(rèn)知研究的探針，有助于對(duì)大腦的聽(tīng)覺(jué)認(rèn)知功能進(jìn)行定量分析。 總之，基于ASSR的聽(tīng)覺(jué)神經(jīng)系統(tǒng)檢測(cè)方法具有時(shí)間分辨率高、檢測(cè)時(shí)間短、定位快、系統(tǒng)便攜的特點(diǎn)，能夠與傳統(tǒng)檢測(cè)方法形成互補(bǔ)，有望在聽(tīng)覺(jué)相關(guān)的腦科學(xué)研究與臨床應(yīng)用上發(fā)揮重要作用。
[Abstract]:Auditory steady-state response (ASSR) is a scalp brain electrical signal induced by periodic stimuli. It is characterized by the constant amplitude and phase of the evoked components corresponding to the stimulus frequency in a long period of time. It is generally believed that the whole auditory nervous system is associated with the ASSR. The auditory nervous system is also an external one, in addition to sound perception and cognition. In the information input channel, the input information is decoded in the central nervous system, and the process of analysis is accompanied by nerve electrical activity, and the conduction to scalp induces evoked EEG signals.
This paper, starting with the physiological structure of the auditory nervous system of the brain, systematically studies the feasibility of the auditory steady state reaction used to detect the functional activities of the nerve center at all levels. The auditory steady-state response has been applied in the field of hearing detection and anesthesia detection. This paper presents an analysis of the clinical auditory related brain function and cognitive function based on ASSR measurement. In this paper, we set up an auditory steady-state response detection platform which is suitable for laboratory and clinic. The method of improving the detection efficiency of ASSR is studied and the best chirp signal is selected as the stimulus of ASSR by comparison and analysis. The special point of this signal is to effectively stimulate the different frequency of cochlea at the same time. Neuron.
Combined with the improved phase analysis method, the ASSR detection is applied. The amplitude information, the prior phase and the phase distribution are analyzed synthetically, and the detection time is shortened to a certain extent and the frequency of the accuracy rate of.ASSR is improved. The amplitude and phase are closely related to the function of the nervous system. The electrical signals will change accordingly. By analyzing the trend and degree of change, the functional state of the nervous system can be obtained, which can provide the basis for clinical diagnosis and treatment. In the clinical detection of brain auditory function, the ASSR analysis of patients with brain stem injury and general anesthesia patients shows that the amplitude of 40Hz and 90Hz's ASSR signals are respectively on brain stem injury and cortex brain, respectively. The function inhibition is more sensitive. With the linear relationship between the intensity of stimulation and the amplitude of ASSR reaction, it can realize the effective classification of brain stem injury and cortical function inhibition, and provide the location reference for the clinical rapid judgment of the injury site. The gamma band ASSR is applied to the detection of cognitive function in the clinical hearing, and the positive and negative speech under amplitude modulation is proposed. The stimulation model, combined with the brain network analysis and graph theory analysis, explores the obvious difference between the ASSR energy distribution and the brain network connection in the auditory cognitive process between normal subjects and auditory subjects. The results explain the possible neuropathology of the auditory hallucination symptoms, indicating that ASSR can be used as a probe for cognitive research and is helpful to the hearing of the brain. Quantitative analysis of cognitive function.
In a word, the ASSR based auditory neural system detection method has the characteristics of high time resolution, short detection time, fast positioning, and portable system, which can complement the traditional detection methods. It is expected to play an important role in the research and clinical application of auditory related brain science.
【學(xué)位授予單位】：清華大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2013
【分類(lèi)號(hào)】：R318.04

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 張森;王斌全;皇甫輝;;多頻聽(tīng)覺(jué)穩(wěn)態(tài)反應(yīng)研究進(jìn)展[J];聽(tīng)力學(xué)及言語(yǔ)疾病雜志;2006年04期

本文編號(hào)：1968735