本文選題：光電容積脈搏波 + 彈性腔模型��； 參考：《浙江大學(xué)》2012年碩士論文

【摘要】：光電容積脈搏波(PPG)蘊(yùn)含著豐富的心血管系統(tǒng)的生理病理信息。目前研究主要基于沒有實(shí)際生理意義的幅度信息,卻忽略了反映全身血管特征的形態(tài)學(xué)參數(shù)。衰減時(shí)間常數(shù)作為常用的形態(tài)學(xué)參數(shù),可用來(lái)評(píng)估動(dòng)脈粥樣硬化等心血管疾病。由于現(xiàn)有衰減時(shí)間常數(shù)的估算方法或需要流量和(或)壓力信息,或容易失效,并不完全適用于PPG。 因此,本論文的研究目標(biāo)是基于PPG的形態(tài)提出一種新的估算衰減時(shí)間常數(shù)的非迭代算法(Non-iterative shape method, NSM),主要工作如下： 1、通過(guò)仿真方法對(duì)比研究單腔及雙腔模型的特點(diǎn),得出雙彈性腔模型復(fù)雜度高、實(shí)用性差的缺點(diǎn),因此采用單彈性腔模型來(lái)描述PPG。 2、仿真驗(yàn)證衰減時(shí)間常數(shù)與PPG形態(tài)的相關(guān)性。分析比較了現(xiàn)有衰減時(shí)間常數(shù)估算方法,得出只有擬合法適用于PPG,由于容易迭代失敗,魯棒性不高,并不是最優(yōu)算法。 3、提出NSM法。從PPG形態(tài)中提取出一個(gè)名為下降支面積差比(ADR)的參數(shù),與衰減時(shí)間常數(shù)建立數(shù)學(xué)關(guān)系,借助分段線性插值估算衰減時(shí)間常數(shù)。 4、仿真和臨床驗(yàn)證NSM法的準(zhǔn)確及可行性。仿真結(jié)果的誤差小于±3%。臨床實(shí)驗(yàn)表明,與擬合法相比,NSM法效率提高近100倍,PPG曲線復(fù)原度幾乎無(wú)差別。 NSM法基于PPG的形態(tài),不需要對(duì)信號(hào)進(jìn)行預(yù)校準(zhǔn)或者歸一化,優(yōu)于現(xiàn)有其他算法。
[Abstract]:PPG contains abundant physiological and pathological information of cardiovascular system. At present, the research is based on the amplitude information without actual physiological meaning, but neglects the morphological parameters which reflect the characteristics of systemic blood vessels. As a common morphological parameter, attenuation time constant can be used to evaluate cardiovascular diseases such as atherosclerosis. The existing methods for estimating attenuation time constants require flow and / or pressure information, or are prone to failure, so they are not fully applicable to PPGs. Therefore, the purpose of this paper is to propose a new non-iterative shape method for estimating attenuation time constants based on the morphology of PPG. The main work is as follows: 1. The characteristics of single cavity model and double cavity model are compared by simulation method, and the shortcomings of high complexity and poor practicability of double elastic cavity model are obtained. Therefore, a single elastic cavity model is used to describe PPG. 2. The correlation between attenuation time constant and PPG morphology is verified by simulation. By analyzing and comparing the existing methods of estimating attenuation time constants, it is concluded that only the fitting method is suitable for PPG, because it is easy to fail in iteration, and its robustness is not high, so it is not the optimal algorithm. 3. NSM method is proposed. A parameter called descending branch area difference ratio (ADR) was extracted from the PPG form, and a mathematical relation was established with the attenuation time constant. The attenuation time constant was estimated by piecewise linear interpolation. 4. The accuracy and feasibility of NSM method were verified by simulation and clinic. The error of simulation results is less than 鹵3. The clinical experiments show that the efficiency of NSM method is nearly 100 times higher than that of the fitting method, and there is almost no difference in the restoration of PPG curve. The NSM method is based on the shape of PPG and does not need to precalibrate or normalize the signal, so it is superior to other existing algorithms.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R318

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