本文選題：導管定位 + 包絡解調(diào)��； 參考：《鄭州大學》2012年碩士論文

【摘要】：研究目的：研究一種消融導管定位信號處理方法,消除呼吸與心跳干擾,獲得導管的位置信息。研究方法：首先根據(jù)定位原理研究了呼吸與心跳運動對于導管定位的影響,據(jù)此提出受到呼吸與心跳運動干擾的導管定位信號數(shù)學模型及其信號處理方法。采用了軟件仿真分析結(jié)合硬件實驗的研究路線,分別提出了兩種信號處理方案。軟件仿真分析采用Matlab數(shù)學軟件來模擬定位信號及其信號處理過程,然后設計出相應的硬件電路來實現(xiàn)信號處理。在硬件設計方面采用模塊化設計思想,按照EDA仿真、面包板實驗、焊接電路板實驗三步走的循序漸進的設計方法進行設計。實施體外胸腔電場模擬實驗,檢驗硬件電路的穩(wěn)定性和可靠性。為了獲得最接近于人體的胸腔環(huán)境,課題組先后開展了二期動物實驗,通過兩期動物實驗來驗證所提出的定位信號數(shù)學模型與定位信號處理方案是否正確。研究結(jié)果：1、將受到干擾的定位信號看作是呼吸與心跳信號對于電場激勵信號調(diào)幅的結(jié)果,調(diào)幅信號包絡的中值就是導管在體內(nèi)相對于體表電極的位置信息,這就是本研究提出的定位信號數(shù)學模型。2、提出了一種新的獲取導管空間位置信息的方法：先將導管采集到的定位信號經(jīng)過一個帶通濾波器后變?yōu)槟骋粋�電場方向的定位信號,之后提取出定位信號包絡線,然后再取其中值,這個中值就是導管電極在某一電場方向上相對于體表電極的位置信息。3、軟件仿真部分采用了Hilbert變換法、平方檢波法、極值曲線擬合法三種包絡解調(diào)方法完成包絡提��；采用低通濾波、median函數(shù)兩種中值提取方法完成中值提取。4、硬件方面,帶通濾波模塊采用三級聯(lián)DABP結(jié)構(gòu)實現(xiàn),包絡解調(diào)模塊采用模擬乘法器來完成,中值提取模塊采用3階MFB結(jié)構(gòu)來實現(xiàn)。各個模塊通過EDA仿真、面包板實驗、焊接板實驗三重測試均達到了比較理想的效果。5、通過體外胸腔電場模擬實驗驗證了本研究提出的定位信號數(shù)學模型以及定位信號處理方法是正確的,硬件電路在實際工作中穩(wěn)定可靠；通過動物實驗進一步證明了導管在活體生物體內(nèi)的定位信號與我們所提出的模型是一致的,而且定位信號處理方案也是正確可行的。研究結(jié)論：通過軟件仿真分析、硬件實驗、模擬胸腔電場實驗和動物實驗等循序漸進的研究,實驗結(jié)果驗證了本研究提出的定位信號數(shù)學模型及其信號處理方案是正確的,能夠消除定位信號中的呼吸與心跳干擾而得到正確的導管位置信息,可以作為進一步研究的理論基礎。
[Abstract]:Objective: to study a method of ablation catheter location signal processing to eliminate respiratory and heartbeat interference and obtain catheter location information. Methods: firstly, according to the principle of location, the influence of respiration and heartbeat motion on catheter location was studied, and the mathematical model of catheter location signal and its signal processing method were put forward, which were interfered by breathing and heartbeat motion. Two kinds of signal processing schemes are proposed by software simulation and hardware experiment. Matlab is used to simulate the positioning signal and its signal processing process, and the corresponding hardware circuit is designed to realize the signal processing. In the aspect of hardware design, the modular design idea is adopted. According to the three-step design method of EDA simulation, bread board experiment and welding circuit board experiment, the design is carried out step by step. The external thoracic electric field simulation experiment was carried out to test the stability and reliability of the hardware circuit. In order to obtain the closest thoracic environment to the human body, the second phase animal experiment was carried out, and the mathematical model of the localization signal and the processing scheme of the localization signal were verified by the two-phase animal experiment. The result of the study: 1, the disturbed location signal is regarded as the result of the amplitude modulation of the respiratory and heartbeat signals to the electric field excitation signal. The median value of the amplitude modulation signal envelope is the position information of the catheter relative to the body surface electrode in the body. This is the mathematical model of location signal proposed in this study. A new method to obtain the location information of the catheter is proposed: firstly, the location signal collected by the catheter passes through a band-pass filter and then becomes the location signal in a certain electric field direction. Then the envelope of the location signal is extracted, and then the value is obtained. The median value is the position information of the catheter electrode relative to the body surface electrode in a certain electric field direction. The software simulation part uses the Hilbert transform method and the square detection method. Three envelope demodulation methods are used to extract the envelope, the median filter median function is used to extract the median value. 4. In the hardware aspect, the bandpass filter module is implemented with the three-level DABP structure. The envelope demodulation module is accomplished by analog multiplier, and the median extraction module is implemented by 3 order MFB structure. Each module through EDA simulation, bread board experiment, The triple test of welding plate has achieved the ideal effect. The mathematical model of the localization signal and the method of processing the positioning signal are proved to be correct by the external thoracic electric field simulation experiment. The hardware circuit is stable and reliable in practical work, and it is further proved by animal experiments that the localization signal of the catheter in vivo is consistent with the model proposed by us, and that the localization signal processing scheme is also correct and feasible. Conclusion: through software simulation analysis, hardware experiment, chest electric field simulation experiment and animal experiment, the experimental results show that the mathematical model and the signal processing scheme proposed in this study are correct. It can be used as the theoretical basis for further research, which can eliminate the interference of respiration and heartbeat in the location signal and obtain the correct location information of the catheter.
【學位授予單位】：鄭州大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R318.6;TH776

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