本文選題：骨單元 + 血管脈動(dòng)��； 參考：《生物醫(yī)學(xué)工程學(xué)雜志》2017年05期

【摘要】：骨組織內(nèi)部存在兩大類液體,一類是血液,一類是間隙流。骨細(xì)胞新陳代謝主要依賴于間隙流微環(huán)境。在骨組織的微觀結(jié)構(gòu)下,骨單元壁中液體的滲流行為是研究的熱點(diǎn)。本文的主要目的是考察中央哈弗管的血管脈動(dòng)對骨單元壁中的間隙流流動(dòng)行為的影響。本文利用COMSOL Multiphysics軟件分別建立了中空的和考慮哈弗管中血管脈動(dòng)的骨單元多孔彈性力學(xué)有限元模型,并對比了軸向載荷下兩種模型中骨單元壁中的液體滲流行為。結(jié)果表明:當(dāng)考慮哈弗管中的血管脈動(dòng)時(shí),骨單元壁中液體的壓力會(huì)明顯增大,而流速幾乎沒有影響。具體地,骨單元孔隙組織液的壓力幅值隨著血壓脈動(dòng)幅值的增大而增大,受脈動(dòng)頻率的變化影響不大,而血壓脈動(dòng)幅值及頻率對骨單元孔隙組織液的流速基本沒有影響。該有限元模型可用來進(jìn)一步研究非軸對稱載荷及微裂縫等復(fù)雜應(yīng)力狀態(tài)下骨單元的多孔彈性力學(xué)行為,并為研究骨的力傳導(dǎo)及力-電傳導(dǎo)機(jī)制提供新方法。
[Abstract]:There are two kinds of fluid in bone tissue, one is blood and the other is interstitial flow. The metabolism of bone cells mainly depends on interstitial flow microenvironment. Under the microstructure of bone tissue, the seepage behavior of fluid in bone cell wall is a hot topic. The main purpose of this paper is to investigate the effect of vascular pulsation of the central Hafer tube on the flow behavior of the interstitial flow in the bone unit wall. In this paper, the finite element model of porous elastic mechanics of bone element is established by using COMSOL Multiphysics software, and the fluid seepage behavior of bone element wall in two models under axial loading is compared. The results show that the pressure of the fluid in the bone unit wall increases obviously when the vessel pulsation in the Hafer tube is taken into account, but the flow rate has little effect on the flow rate. Specifically, the pressure amplitude of bone unit pore tissue increased with the increase of blood pressure pulsation amplitude, and was not affected by the fluctuation frequency, but the blood pressure fluctuation amplitude and frequency had no effect on the flow rate of bone unit pore tissue fluid. The finite element model can be used to further study the porous elastic behavior of bone elements under complex stresses such as non-axisymmetric loads and micro-cracks, and provide a new method for the study of force conduction and force-electric conduction mechanism of bone.
【作者單位】： 太原理工大學(xué)力學(xué)學(xué)院材料強(qiáng)度與結(jié)構(gòu)沖擊山西省重點(diǎn)實(shí)驗(yàn)室;
【基金】：國家自然科學(xué)基金(11632013,11472185,11702183) 山西自然科學(xué)基金(2016021145) 山西省高等學(xué)校創(chuàng)新人才支持計(jì)劃資助項(xiàng)目(143230146-S) 山西省高等學(xué)�？萍紕�(chuàng)新項(xiàng)目(2014116,2017135) 大連理工大學(xué)精細(xì)化工國家重點(diǎn)實(shí)驗(yàn)室開放課題基金項(xiàng)目(KF1511)
【分類號】：O35;R318.01
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本文編號：1909612