本文選題：磷酸鈣陶瓷材料 + 殼聚糖　； 參考：《西南交通大學(xué)》2012年碩士論文

【摘要】：骨缺損是常見的臨床疾病,多是由于創(chuàng)傷、感染、腫瘤等所導(dǎo)致,通常需要進(jìn)行骨移植治療。目前主要的治療方案有自體骨移植、異體骨移植、骨組織工程支架。其中骨組織工程支架最為引人注目。磷酸鈣類陶瓷材料是最常見的骨組織工程支架材料之一,由于高致密度的磷酸鈣類陶瓷材料在體內(nèi)降解很慢,人們常常通過溶膠凝膠等方法制備高孔隙率和高貫通性的可降解磷酸鈣類陶瓷材料,不少復(fù)合高分子凝膠是良好的緩釋材料,具有較好的生物相容性,可以復(fù)合到外層孔壁上,進(jìn)一步改善提高磷酸鈣陶瓷材料的生物學(xué)性質(zhì)。而復(fù)合凝膠材料的設(shè)計和選擇是關(guān)鍵。 殼聚糖是自然界中廣泛存在的天然多糖,具有良好的生物相容性和可降解性。殼聚糖基水凝膠是目前研究最多的水凝膠材料之一。 本課題以琥珀酸酐改性改善了殼聚糖的水溶性,通過高碘酸鈉氧化了結(jié)冷膠和海藻酸鈉,用可溶性殼聚糖和生成的氧化產(chǎn)物反應(yīng)分別制備了兩種殼聚糖基水凝膠。通過考察對比其凝膠時間、溶脹性能、降解性能等性能并與成纖維細(xì)胞和成骨細(xì)胞共培養(yǎng)后發(fā)現(xiàn),兩種復(fù)合水凝膠都具有良好的生物相容性和降解性,同時N-琥珀酰殼聚糖/氧化結(jié)冷膠復(fù)合水凝膠的溶脹性能,降解性能,生物相容性都要優(yōu)于N-琥珀酰殼聚糖/氧化海藻酸鈉復(fù)合水凝膠。更加適合作為凝膠材料復(fù)合至磷酸鈣陶瓷材料上
[Abstract]:Bone defect is a common clinical disease, usually caused by trauma, infection, tumor and so on. At present, the main treatment options are autologous bone transplantation, allograft bone graft, bone tissue engineering scaffold. Bone tissue engineering scaffolds are most attractive. Calcium phosphate ceramic material is one of the most common scaffold materials for bone tissue engineering, because the high density calcium phosphate ceramic material degrades very slowly in vivo. Biodegradable calcium phosphate ceramics with high porosity and high permeability are often prepared by sol-gel methods. Many composite polymer gels are good sustained-release materials with good biocompatibility and can be compounded to the outer pore wall. Further improve the biological properties of calcium phosphate ceramic materials. The design and selection of composite gel materials is the key. Chitosan is a kind of natural polysaccharide, which has good biocompatibility and biodegradability. Chitosan-based hydrogel is one of the most studied hydrogel materials. In this paper, the water solubility of chitosan was improved by the modification of succinic anhydride. Two chitosan based hydrogels were prepared by sodium periodate oxidation of cold glue and sodium alginate. The gel time, swelling and degradation properties were compared and co-cultured with fibroblasts and osteoblasts. The results showed that the two hydrogels had good biocompatibility and biodegradability. At the same time, the swelling, degradation and biocompatibility of N- succinyl chitosan / oxidized cold gel were better than those of N- succinyl chitosan / sodium alginate composite hydrogels. It is more suitable for composite as gel material to calcium phosphate ceramic material.
【學(xué)位授予單位】：西南交通大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R318.08

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