本文選題：生物醫(yī)學工程 + 脊髓損傷　； 參考：《中國組織工程研究》2015年21期

【摘要】：背景:以脫細胞脊髓基質(zhì)材料為構(gòu)架的脊髓生物支架,已被證實可恢復或部分恢復受損的脊髓神經(jīng)功能。目的:介紹脫細胞脊髓基質(zhì)支架的制備方法和部分生物特性,對近年來其在脊髓組織工程中的應用及進展作一概述。方法:應用計算機檢索CNKI和PubM ed數(shù)據(jù)庫中2005年1月至2014年10月關(guān)于脫細胞脊髓基質(zhì)支架材料在脊髓損傷中應用的文章,在主題和摘要中,中文以"脫細胞脊髓,支架材料,脊髓損傷,組織工程學"為檢索詞檢索,英文以"acellular spinal cord;engineering tissue;spinal cord injury;scaffold"為檢索詞進行檢索。結(jié)果與結(jié)論:脫細胞脊髓基質(zhì)支架具有較低的抗原性、優(yōu)良的生物相容性及類似脊髓的三維支架結(jié)構(gòu),但存在力學性能差及結(jié)構(gòu)不穩(wěn)定等缺點。通過京尼平、戊二醛等交聯(lián)劑改性后可明顯提高支架的生物性能。目前國內(nèi)外已對脫細胞脊髓基質(zhì)支架在神經(jīng)修復再生方面的應用做了一些探索,為脊髓組織工程學打下了基礎(chǔ)。由于脫細胞脊髓基質(zhì)支架的諸多優(yōu)點,脫細胞脊髓基質(zhì)材料有望成為脊髓組織工程學的理想材料。
[Abstract]:Background: acellular spinal cord biomaterial scaffolds have been demonstrated to restore or partially restore damaged spinal cord nerve function. Aim: to introduce the preparation method and some biological characteristics of acellular spinal cord matrix scaffolds, and to summarize its application and progress in spinal cord tissue engineering in recent years. Methods: from January 2005 to October 2014, articles on the application of acellular spinal cord matrix scaffolds in CNKI and PubM ed databases were searched by computer. In the main topic and abstract, the Chinese version of "acellular spinal cord, scaffold material" was used. Spinal cord injury, tissue engineering was used as the key word, and "acellular spinal cordant tissue engineering cord injury-scaffold" was used as the key word. Results and conclusion: acellular spinal cord matrix scaffold has low antigenicity, excellent biocompatibility and three-dimensional scaffold structure similar to spinal cord, but it has some disadvantages such as poor mechanical properties and unstable structure. The biological properties of the scaffold were improved after modification with genipin, glutaraldehyde and other crosslinking agents. At present, the application of acellular spinal cord matrix scaffold in nerve repair and regeneration has been explored at home and abroad, which has laid a foundation for spinal cord tissue engineering. Because of the advantages of acellular spinal cord matrix scaffold, acellular spinal cord matrix material is expected to be an ideal material for spinal cord tissue engineering.
【作者單位】： 天津中醫(yī)藥大學;天津市神經(jīng)創(chuàng)傷修復重點實驗室;武警后勤學院附屬醫(yī)院腦創(chuàng)傷與神經(jīng)疾病研究所;武警后勤學院附屬醫(yī)院;
【基金】：天津市科技支撐計劃重點項目(14ZCZDGX00500) 國家自然科學基金青年項目(11102235) 天津市自然科學基金重點項目(12JCZDJC24100) 天津市衛(wèi)生局科技基金項目(2013KZ134) 武警后勤學院附屬醫(yī)院種子基金項目(FYM201432)~~
【分類號】：R318.08

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本文編號：1844063