本文選題：熒光層析成像 + 非接觸�。� 參考：《天津大學(xué)》2012年碩士論文

【摘要】：相對(duì)于目前臨床應(yīng)用的乳腺影像方法,漫射光層析成像(Diffuse Optical Tomography, DOT)因其良好的特異性以及實(shí)時(shí)、安全性而成為有潛力的乳腺影像新技術(shù)。在此基礎(chǔ)上發(fā)展起來的熒光層析成像(Fluorescence Diffuse Optical Tomography,FDOT)采用吲哚菁綠(Indocyanine green, ICG)作為熒光增強(qiáng)劑,可使圖像對(duì)比度比DOT高2-4倍。FDOT不僅可采用產(chǎn)率作為重建參數(shù),也可通過同時(shí)重建熒光壽命為癌癥的早期診斷提供組織體功能信息,從而提高乳腺癌早期診斷的準(zhǔn)確率。 光學(xué)成像中的傳統(tǒng)探測(cè)模式采用光纖與成像倉直接接觸進(jìn)行測(cè)量。這種接觸測(cè)量方式限制了數(shù)據(jù)規(guī)模和空間分辨率的提高,調(diào)節(jié)過程繁瑣、耗時(shí),并且在光纖匹配以及調(diào)整中易出現(xiàn)誤差。為解決以上問題,本組以現(xiàn)有的單通道基于時(shí)間相關(guān)單光子計(jì)數(shù)(Time-Correlated Single Photon Counting Techniques, TCSPC)的時(shí)間分辨測(cè)量系統(tǒng)為基礎(chǔ),搭建了適于在體乳房成像的時(shí)域非接觸式空間光掃描系統(tǒng),相對(duì)于傳統(tǒng)測(cè)量方法本方案可增大空間采樣量、減小測(cè)量誤差,提高空間分辨率。為實(shí)現(xiàn)系統(tǒng)的連續(xù)掃描及集成控制,利用集成了Qt插件的Visual Studio 2008平臺(tái)進(jìn)行了集成控制軟件開發(fā),實(shí)現(xiàn)了連續(xù)測(cè)量掃描以及測(cè)量曲線的實(shí)時(shí)顯示等功能。 利用仿體實(shí)驗(yàn)對(duì)所搭建系統(tǒng)進(jìn)行了驗(yàn)證。在DOT實(shí)驗(yàn)中,利用該系統(tǒng)對(duì)目標(biāo)仿體中異質(zhì)體的吸收與約化散射系數(shù)進(jìn)行了成像。在FDOT實(shí)驗(yàn)中,分別對(duì)單目標(biāo)體和雙目標(biāo)體進(jìn)行成像。基于本組已發(fā)展的DOT和FDOT圖像重建算法進(jìn)行了圖像重建,結(jié)果表明: DOT實(shí)驗(yàn)中光學(xué)參數(shù)重建值與實(shí)際值基本相符,重建目標(biāo)與真實(shí)目標(biāo)位置大小相符;FDOT單目標(biāo)體實(shí)驗(yàn)中對(duì)熒光目標(biāo)的產(chǎn)率與壽命進(jìn)行重建;通過熒光產(chǎn)率的重建可有效對(duì)中心距為20mm、邊距為15mm的目標(biāo)體進(jìn)行分辨進(jìn)行分辨且能夠?qū)崿F(xiàn)不同濃度的雙目標(biāo)體相對(duì)定量重建。實(shí)驗(yàn)結(jié)果證明了該系統(tǒng)重建組織體光學(xué)參數(shù)以及進(jìn)行熒光層析成像的可行性,進(jìn)一步發(fā)展可推動(dòng)應(yīng)用于乳腺癌檢測(cè)的光學(xué)層析技術(shù)發(fā)展。
[Abstract]:Compared with the current clinical breast imaging methods, Diffuse Optical Tomography (DOT) has become a potential new mammography technology due to its good specificity, real-time and safety. Based on this, fluorescence Diffuse Optical TomographyFDOT, which uses indocyanine green (ICG) as fluorescence intensifier, can make image contrast 2-4 times higher than DOT. FDOT can not only use yield as reconstruction parameter. It can also improve the accuracy of early diagnosis of breast cancer by simultaneously rebuilding fluorescence lifetime to provide tissue and body function information for early diagnosis of cancer. The traditional detection mode in optical imaging is measured by direct contact between optical fiber and imaging bin. This method of contact measurement limits the improvement of data scale and spatial resolution, and the adjustment process is tedious and time-consuming, and errors are easy to occur in the optical fiber matching and adjustment. In order to solve the above problems, based on the existing time-related Single Photon Counting technique (TCSPC-based) time-resolved measurement system based on time-dependent single-photon counting, a time-domain contactless spatial light scanning system suitable for in vivo mammography was built. Compared with the traditional measurement method, this scheme can increase the spatial sampling amount, reduce the measurement error and improve the spatial resolution. In order to realize the continuous scanning and integrated control of the system, the integrated control software is developed on the platform of Visual Studio 2008 which integrates QT plug-in. The functions of continuous measurement scan and real-time display of measuring curve are realized. The system is verified by body-imitating experiment. In the DOT experiment, the absorption and reduced scattering coefficients of the heterogeneity in the target are imaged by the system. In the FDOT experiment, the single object and the double object are respectively imaged. Based on the developed DOT and FDOT image reconstruction algorithms, the results show that the reconstruction values of the optical parameters in the DOT experiment are in good agreement with the actual values. The yield and lifetime of fluorescent target were reconstructed by FDOT single object experiment. The reconstruction of fluorescence yield can effectively resolve the target with central distance of 20mm and edge distance of 15mm, and can realize the relative quantitative reconstruction of different concentrations of double objects. The experimental results show that the system is feasible to reconstruct the optical parameters of tissue bodies and to perform fluorescence tomography. The further development of optical tomography technology for breast cancer detection can be promoted.
【學(xué)位授予單位】：天津大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R318.51

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