發(fā)布時(shí)間：2018-04-22 15:39

  本文選題：降解性可調(diào) + 多殼層化中空微球��； 參考：《無機(jī)材料學(xué)報(bào)》2014年06期

【摘要】：利用硅灰石(CaSiO3)和β-磷酸三鈣(β-TCP)在骨損傷環(huán)境中降解速率存在顯著性差異的基本特性,以海藻多糖凝膠球?yàn)槟０?運(yùn)用層 層包裹方法構(gòu)建CaSiO3、β-TCP交替包裹的多殼層化中空微球。首先,將海藻酸鈉與硅酸鈉的混合水溶膠逐滴加入到溫和攪拌的硝酸鈣水溶液中,形成由水合硅酸鈣鹽為殼層的海藻多糖基復(fù)合微球,然后將該復(fù)合微球依次浸入到含β-TCP的海藻酸鈉溶液和含CaSiO3的海藻酸鈉溶液中,溫和攪拌后將微球懸浮液分離,再經(jīng)真空冷凍干燥和850℃煅燒處理,從而獲得以CaSiO3為最內(nèi)殼層并具有雙殼層或三殼層的中空微球。按類似步驟也可以制備以β-TCP為最內(nèi)殼層的多殼層中空微球。運(yùn)用SEM、EDX、XRD和FTIR對該類微球的微結(jié)構(gòu)和組成進(jìn)行了分析。運(yùn)用弱酸性Tris緩沖液(pH=5.2)對雙殼層中空微球的降解。實(shí)驗(yàn)證明,緩沖液中硅、磷濃度變化特征與其外殼層、內(nèi)殼層化學(xué)組成(即β-TCP或CaSiO3)密切相關(guān)。本研究結(jié)果對構(gòu)建降解速率階段可調(diào)的復(fù)合陶瓷多孔生物材料以及研究原位骨再生效率與孔道網(wǎng)絡(luò)演化規(guī)律之間關(guān)系等具有重要學(xué)術(shù)價(jià)值。
[Abstract]:Taking wollastonite (wollastonite) CaSiO3) and 尾 -tricalcium phosphate (尾 -TCP2) as the basic characteristics of significantly different degradation rates in bone injury environment, the hollow hollow microspheres coated with CaSiO3 and 尾 -TCP were constructed by using the seaweed polysaccharide gel sphere as template, and the method of encapsulating CaSiO3 and 尾 -TCP alternately. First, the mixture of sodium alginate and sodium silicate was added to the mildly stirred calcium nitrate aqueous solution one by one to form the algal polysaccharide based composite microspheres with calcium silicate hydrate as the shell layer. The composite microspheres were then immersed in the sodium alginate solution containing 尾 -TCP and the sodium alginate solution containing CaSiO3 in turn. After mild stirring, the suspension was separated, then freeze-dried in vacuum and calcined at 850 鈩，

本文編號：1787847