本文選題：瓣葉運(yùn)動(dòng)流阻模型 + 左心血液循環(huán)��； 參考：《中國(guó)生物醫(yī)學(xué)工程學(xué)報(bào)》2017年03期

【摘要】：提出一個(gè)可以準(zhǔn)確合理地模擬二尖瓣動(dòng)力學(xué)特性的瓣葉運(yùn)動(dòng)流阻模型�？紤]影響二尖瓣瓣葉運(yùn)動(dòng)的跨瓣壓差和血流推力,建立二尖瓣運(yùn)動(dòng)的控制方程,提出依賴于瓣葉打開(kāi)角度θ的瓣葉運(yùn)動(dòng)流阻模型,把該模型應(yīng)用于零維左心血液循環(huán)系統(tǒng),得到血液動(dòng)力學(xué)特性。在保持心輸出量和反流分?jǐn)?shù)一致的條件下,比較該模型、瞬態(tài)關(guān)閉的階梯流阻模型和經(jīng)驗(yàn)指定的時(shí)變流阻模型。結(jié)果發(fā)現(xiàn),瓣葉運(yùn)動(dòng)流阻模型能反映瓣膜關(guān)閉過(guò)程中的血液動(dòng)力學(xué),如壓差和流量的滯后性以及關(guān)閉流量,同時(shí)該模型可以通過(guò)調(diào)整單位轉(zhuǎn)動(dòng)慣量跨瓣壓差影響系數(shù)Kp和血流影響系數(shù)Kb的大小,改變瓣膜打開(kāi)過(guò)程和關(guān)閉過(guò)程所需時(shí)間,瓣膜打開(kāi)和關(guān)閉時(shí)間分別為50.0和40.2 ms。該模型可彌補(bǔ)階梯流阻模型中忽略瓣膜運(yùn)動(dòng)過(guò)程的瞬態(tài)關(guān)閉的缺點(diǎn),同時(shí)也能避免時(shí)變流阻模型中關(guān)閉起始時(shí)間的不合理性。此模型較為合理準(zhǔn)確地模擬二尖瓣關(guān)閉過(guò)程的動(dòng)力學(xué)特性,且簡(jiǎn)單易控制。
[Abstract]:A flow resistance model of mitral valve motion is proposed, which can accurately and reasonably simulate the dynamic characteristics of mitral valve.Considering the pressure difference and blood flow thrust of mitral valve, the governing equation of mitral valve motion is established, and a flow resistance model of mitral valve motion dependent on lobular opening angle 胃 is proposed. The model is applied to the zero-dimensional left ventricular circulation system.The hemodynamic properties were obtained.Under the condition that the cardiac output and the reflux fraction are consistent, the model, the transient closed step flow resistance model and the empirically specified time-varying resistance model are compared.The results showed that the valve motion resistance model could reflect the hemodynamics during valve closure, such as pressure difference, hysteresis of flow rate and closure flow rate.At the same time, the model can change the opening and closing time of the valve by adjusting the magnitude of the pressure difference of unit moment of inertia and the influence coefficient of blood flow K _ b. The opening and closing time of the valve is 50.0 and 40.2 msrespectively.This model can make up for the shortcoming of neglecting the transient closure of valve movement in the step flow resistance model and avoid the irrationality of the starting time of closure in the time-varying flow resistance model.The model is more reasonable and accurate to simulate the dynamic characteristics of mitral valve closure process, and is simple and easy to control.
【作者單位】： 江蘇大學(xué)流體機(jī)械工程技術(shù)研究中心;德州理工大學(xué)機(jī)械工程系;
【基金】：江蘇省高層次創(chuàng)新創(chuàng)業(yè)人才引進(jìn)計(jì)劃基金 江蘇省江蘇特聘教授計(jì)劃基金 江蘇省自然科學(xué)基金項(xiàng)目(BK20130539)
【分類號(hào)】：R318.0

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